A5067194680- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- Receptor Mechanisms and Signaling
- Air Quality and Health Impacts
- Medical Imaging and Pathology Studies
- Eosinophilic Esophagitis
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
- Biochemical effects in animals
- Immune cells in cancer
- Inflammation biomarkers and pathways
- Fibroblast Growth Factor Research
- Immune Cell Function and Interaction
Hunan Cancer Hospital
2023-2025
Central South University
2008-2025
Cisplatin (DDP)-based chemoradiotherapy is one of the standard treatments for nasopharyngeal carcinoma (NPC). However, sensitivity and side effects DDP to patients remain major obstacles NPC treatment. This research aimed study regulated by cancer-associated fibroblasts (CAFs) through modulating ferroptosis. We demonstrated that triggered ferroptosis in cells, it inhibited tumor growth via inducing xenograft model. CAFs secreted high level FGF5, thus inhibiting DDP-induced cells....
Abstract Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce anticancer immunity. However, the regulatory mechanisms macrophage polarization and its functional roles in nasopharyngeal carcinoma (NPC) progression need be further explored. Here we found that SPLUNC1 was highly expressed responsible for polarization. JAK/STATs pathway activation involved SPLUNC1-mediated Importantly, regulation affected CM-mediated influence on NPC cell proliferation migration....