A5100662130- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Melanoma and MAPK Pathways
- Signaling Pathways in Disease
- Plant Gene Expression Analysis
- Cell Adhesion Molecules Research
- Photosynthetic Processes and Mechanisms
- Animal Nutrition and Physiology
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Plant Stress Responses and Tolerance
- Galectins and Cancer Biology
- Gout, Hyperuricemia, Uric Acid
- Cytokine Signaling Pathways and Interactions
- Plant-Derived Bioactive Compounds
- Resilience and Mental Health
- Genomics, phytochemicals, and oxidative stress
- Healthcare professionals’ stress and burnout
- Retinoids in leukemia and cellular processes
- Physiological and biochemical adaptations
- Pluripotent Stem Cells Research
- melanin and skin pigmentation
- Ubiquitin and proteasome pathways
Hunan Cancer Hospital
2020-2025
Central South University
2018-2025
Sichuan Animal Science Academy
2013-2024
Second People Hospital of Hunan
2024
Xiangya Hospital Central South University
2018-2023
Union Hospital
2023
Huazhong University of Science and Technology
2023
Chinese Academy of Sciences
2021-2022
University of Chinese Academy of Sciences
2021-2022
Institute of Botany
2021-2022
β-conglycinin has been identified as one of the major feed allergens. However, studies on fish are scarce. This study investigated effects growth, digestive and absorptive ability, inflammatory response, oxidative status gene expression juvenile Jian carp (Cyprinus carpio var. Jian) in vivo their enterocytes vitro. The results indicated that specific growth rate (SGR), intake, efficiency were reduced by β-conglycinin. In addition, activities trypsin, chymotrypsin, lipase, creatine kinase,...
Abstract This study investigated the effects of glycinin on growth, intestinal oxidative status, tight junction components, cytokines and apoptosis signalling factors fish. The results showed that an 80 g/kg diet exposure for 42 d caused poor growth performance depressed function juvenile Jian carp ( Cyprinus carpio var. Jian). Meanwhile, dietary induced increases in lipid peroxidation protein oxidation; it reductions superoxide dismutase (SOD), catalase glutathione peroxidase (GPx)...
Cisplatin (DDP)-based chemoradiotherapy is one of the standard treatments for nasopharyngeal carcinoma (NPC). However, sensitivity and side effects DDP to patients remain major obstacles NPC treatment. This research aimed study regulated by cancer-associated fibroblasts (CAFs) through modulating ferroptosis. We demonstrated that triggered ferroptosis in cells, it inhibited tumor growth via inducing xenograft model. CAFs secreted high level FGF5, thus inhibiting DDP-induced cells....
Abstract Rhododendron lapponicum L. is a familiar ornamental plant worldwide with important and economic value. However, full-length R. transcriptome still lacking. In the present study, we used Pacific Biosciences single-molecule real-time sequencing technology to generate transcriptome. A total of 346,270 non-chimeric reads were generated, from which obtained 75,002 high-quality transcripts. We identified 55,255 complete open reading frames, 7,140 alternative splicing events 2,011 long...
CD44v6 chimeric antigen receptor T (CD44v6 CAR-T) cells demonstrate strong anti-tumor ability and safety in acute myeloid leukemia (AML). However, the expression of on leads to transient fratricide exhaustion CAR-T cells, which affect application CAR-T. The function AML are associated with DNA methylation. Hypomethylating agents (HAMs) decitabine (Dec) azacitidine (Aza) have been widely used treat AML. Therefore, there may be synergy between HAMs treatment AML.CD44v6 pretreated Dec or Aza...
Dermatofibrosarcoma protuberans (DFSP) is a rare and marginal cutaneous sarcoma of intermediate-grade malignancy, for which the genomic landscape remains unclear. Understanding DFSP will help to further classify pathway malignant development in soft tissue.To identify comprehensive molecular pathogenesis DFSP.In this study, features, with 53 tumour-normal pairs DFSP, were revealed by whole-genome sequencing.The mutational signature 1 (C > T mutation at CpG dinucleotides) featured resulting...
Visualizing organelles in living cells is a powerful method to analyze their intrinsic mechanisms. Easy observation of chlorophyll facilitates the study underlying mechanisms chloroplasts, but not other plastid types. Here, we constructed transgenic plant enabling visualization plastids pollen grains. Combination plastid-targeted fluorescent protein with pollen-specific promoter allowed us observe precise number, size and morphology grains wild type ftsZ1 mutant, whose responsible gene plays...
Monoamine oxidases (MAO-A, MAO-B) metabolize biogenic amines and have been implicated in neuronal apoptosis. Although apoptosis is an important process embryo development, the role of MAO isoenzymes has not investigated detail. We found that expression MAO-A MAO-B can be detected early on during development. Expression levels remained constant until around midgestation but then dropped to almost undetectable toward birth. Similar kinetics were observed brain. Isoform-specific silencing...