A5100356014- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Aquaculture Nutrition and Growth
- Modular Robots and Swarm Intelligence
- DNA and Biological Computing
- FOXO transcription factor regulation
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Free Radicals and Antioxidants
- Sperm and Testicular Function
- Drug-Induced Hepatotoxicity and Protection
- Food composition and properties
- Ginseng Biological Effects and Applications
- Sexual Differentiation and Disorders
- Reproductive Biology and Fertility
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Wound Healing and Treatments
- Metabolism, Diabetes, and Cancer
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Huazhong University of Science and Technology
2014-2023
Shandong Agricultural University
2023
Ministry of Agriculture and Rural Affairs
2023
Inner Mongolia University of Science and Technology
2023
State Key Laboratory of Medicinal Chemical Biology
2022
Nankai University
2022
Union Hospital
2021
National Cancer Institute
2019-2020
Natural products from herbal medicines have long been investigated for their potentials as cancer therapeutics. Besides the development of several medicine-derived anti-cancer agents, such paclitaxel, vincristine and podophyllotoxin, many recent laboratory findings demonstrated that brusatol, a quassinoid seeds Brucea sumatrana, exhibits potent tumor suppressing effect with improved disease outcome. Our finding further brusatol synergizes intrinsic metabolic burden in cells.Here, we...
Significance IDH1 mutation is a common genetic abnormality in human malignancies, whereas selective therapeutics for IDH1-mutated malignancies remain unavailable. Our present study reveals that cancer cells exhibit addiction to Nrf2-governed antioxidative pathways. Blockade of Nrf2 transcriptional activity achieved synergistic lethality with neomorphic mutation. We also showed triptolide serves as potent inhibitor, which inhibited and led apoptotic changes via redox catastrophe. believe our...
Mulberry granules (MLD) is a traditional Chinese medicine prescription that has been used in the treatment of diabetes for many years. Recently, we found MLD protected heart from diabetes-associated cardiomyopathy when it was to treat diabetes. However, beneficial effects and possible mechanism remain unknown. To elucidate these effects, an experimental myocardial ischemia/reperfusion (MI/R) injury model rats this study. Male C57BL/6 mice were injected with streptozotocin induce The...
High concentrations of antioxidants can exert pro-oxidative effects, elevate the level intracellular reactive oxygen species (ROS), and cause oxidative stress in cells. We previously found that high curcumin, a natural polyphenol antioxidant, elevated ROS levels upregulated expression histone deacetylase 1 (HDAC1) human gastric cancer cells (hGCCs); however, its potential mechanisms subsequent functions have not been elucidated. In present study, we treated hGCCs with detected several...
The current study aimed to investigate the effects of dietary Galla Chinensis tannin (GCT) supplementation on antioxidant capacity and gut microbiota composition in broilers. Two hundred eighty-eight Arbor Acres broiler chicks were divided into CON group GCT group; each treatment contained 6 replicates with 24 per replicate for a period 42 days, fed either basal diet or supplemented 300 mg/kg GCT. Results revealed that significantly increased glutathione peroxidase (GSH-Px) activity (p <...
Spiking neural P systems with astrocytes (SNPA systems, for short) are a class of distributed parallel computing devices inspired from the way spikes pass along synapses between neurons. In this work, we investigate computational power SNP
Mutations in isocitrate dehydrogenase (IDH1/2) are the most prevalent genetic abnormalities lower grade glioma. Neomorphic enzyme activity of mutant IDH1/2 leads to production oncometabolite 2-hydroxyglutarate, accompanied with disruption redox balance through aberrant NADP+/NADPH metabolism. The remarkable accumulation reactive oxygen species (ROS) suggests distinctive metabolic stress and vulnerability cancer cells, implying potential for selective therapeutic approaches IDH1-mutated...
Abstract BACKGROUND Mutations in isocitrate dehydrogenase (IDH1/2) are frequent genetic abnormalities human malignancies. IDH1/2-mutated cancers a recently defined disease entity with distinctive patterns of tumor cell biology, metabolism and resistance to therapy. Molecular targeting approaches against this cluster remain limited. METHODS We investigated the redox homeostasis IDH1 mutant-transduced cells patient-derived brain initiating cells. The importance antioxidant genes was confirmed...
Background: Isocitrate dehydrogenase (IDH) mutation frequently occurs in low grade glioma and secondary glioblastoma, characterizing by the abnormally catalyzation of alpha-ketoglutarate (α-KG) to D-2-hydroxyglutarate (D-2-HG), which induces CpG island methylator phenotype, as well metabolic reprogramming high reactive oxygen species (ROS) generation. Our previous data showed that nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a crucial role maintaining redox homeostasis...
Abstract Background : Whole-grain intake assessed through dietary recording methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in several epidemiological studies. However, limited studies have evaluated association between whole-grain and MetS when using objective biomarkers of intake. The aim this study was examine plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker wheat rye intake, Chinese population. Methods A case-control 667...
Abstract Background Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long non-coding RNAs (lncRNAs) reportedly play essential roles in cell aging. However, the mechanisms by which lncRNAs influence mesenchymal aging have not been investigated. Methods The lncRNA senescence-associated RNA (SAN) was identified among differentially expressed ASCs obtained from old and young volunteer donors. with...