A5058583649- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ginseng Biological Effects and Applications
- Immune cells in cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Heat shock proteins research
- Food Quality and Safety Studies
- Tribology and Lubrication Engineering
- Magnetic Bearings and Levitation Dynamics
- Natural product bioactivities and synthesis
- Polyomavirus and related diseases
- Carbohydrate Chemistry and Synthesis
- Breast Cancer Treatment Studies
- Proteins in Food Systems
- Gear and Bearing Dynamics Analysis
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
Nankai University
2016-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2025
Huazhong Agricultural University
2023-2024
State Key Laboratory of Medicinal Chemical Biology
2018-2024
Fudan University
2020-2024
Zhongshan Hospital
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2020-2024
Northwest A&F University
2023
Abstract Ferroptosis is a newly identified iron-dependent form of death that becoming increasingly recognized as promising avenue for cancer therapy. N6-methyladenosine (m 6 A) the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, crucial role m A regulating ferroptosis during colorectal (CRC) tumorigenesis remains elusive. Herein, we find increased ferroptotic cell and correlates with decreased demethylase fat mass obesity-associated protein...
Background and Aims: Circulating tumor cells (CTCs) are precursors of cancer metastasis. However, how CTCs evade immunosurveillance during hematogenous dissemination remains unclear. Approach Results: We identified CTC-platelet adhesions by single-cell RNA sequencing multiplex immunofluorescence blood samples from multiple types. Clinically, aggregates were associated with significantly shorter progression-free survival overall in patients HCC. In vitro, ex vivo, vivo assays demonstrated...
Copper chaperone for superoxide dismutase (CCS) is a critical component of oxidation-reduction system and functions as potential tumor promoter in several cancers. However, the function clinical significance CCS breast cancer remains unclear. Here, we found was highly expressed cancer, where it promoted cell proliferation migration. Suppression expression sufficient to attenuate phosphorylation level ERK1/2, increase accumulation reactive oxygen species (ROS). Mechanistically, that knockdown...
Abstract Renal fibrosis is the common feature of all progressive kidney diseases and exerts great burden on public health worldwide. The maladaptive repair mechanism tubular epithelial cells, an important mediator renal fibrogenesis, manifests with partial epithelial–mesenchymal transition (EMT) cell cycle arrest. aim this study to investigate possible correlation between EMT arrest, elucidate underlying mechanism. We examined human allograft samples interstitial three mice models,...
Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein arginine methyltransferase 6 (PRMT6) highly expressed in cancer required for cell metabolism, tumorigenicity, cisplatin response PRMT6 regulated oxidative pentose phosphate pathway (PPP) flux glycolysis human by increasing activity 6-phospho-gluconate dehydrogenase (6PGD) α-enolase (ENO1). Furthermore,...
Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine not only involved in protein metabolism, but also participates metabolism of lipids carbohydrates. The liver important place lipids, carbohydrates, proteins. metabolic process biological macro-molecules a basis maintaining physiological activities organisms, cross-linking mechanism these processes still unclear. Here, we found tyrosine-metabolizing enzymes, were specifically highly...
Abstract Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of (SDMA), and plays predominantly roles in human cancers, including ovarian cancer. However, the exactly underlying mechanisms PRMT5 contributing to progression cancer mediated by reprogramming cell metabolism remain largely elusive. Here, we report that highly expressed correlates with poor survival Knockdown or pharmaceutical inhibition sufficient decrease glycolysis...
Periodontitis, a chronic inflammatory oral disease resulting from plaque biofilms, affects about 743 million individuals worldwide. However, the efficacy of current treatments is hampered by challenges in delivering antibiotics to recalcitrant biofilms and bacterial resistance, thereby impeding successful treatment infectious diseases. To address issues, an antibacterial photothermal material was designed, comprising spherical structure zinc oxide (ZnO) wrapped with triiron tetraoxide...
Herpes simplex virus 1 (HSV-1) remodels nuclear membranes during egress. Although the UL31 and UL34 proteins control nucleocapsid transit in infected cells, molecular interactions required for their function are unclear. Here we report that γ134.5 gene product of HSV-1 facilitates release to cytoplasm through bridging UL31/UL34 complex, cellular p32, protein kinase C. Unlike wild-type virus, an HSV mutant devoid or its amino terminus is crippled viral growth release. This attributable a...
Glioblastoma (GBM) is the most prevalent malignant tumor in central nervous system. Aerobic glycolysis, featured with elevated glucose consumption and lactate production, confers selective advantages on GBM by utilizing nutrients to support rapid cell proliferation growth. Pyruvate kinase 2 (PKM2), last rate-limiting enzyme of known regulate aerobic considered as a novel cancer therapeutic target. Herein, we aim describe cellular functions mechanisms small molecular compound...
Eukaryotic elongation factor 1A (eEF1A) is among the most abundant proteins in eukaryotic cells. Evolutionarily conserved across species, eEF1A charge of translation for protein biosynthesis as well a plethora non-translational moonlighting functions cellular homeostasis. In malignant cells, however, becomes pleiotropic driver cancer progression via broad diversity pathways, which are not limited to hyperactive translational output. past decades, mounting studies have demonstrated causal...
Ischemia-reperfusion injury (IRI) is an inevitable process in renal transplantation that significantly increases the risk of delayed graft function, acute rejection, and even loss. Formyl peptide receptor 2 (FPR2) important multiple septic aseptic injuries, but its functions kidney IRI are still unclear. This study was designed to reveal pathological role FPR2 functional mechanisms.To explore mechanism IRI, model rats were sacrificed after surgery. Immunofluorescence, enzyme-linked...
To analyze and compare prospectively the curative effects between mammotome-assisted minimally invasive resection (MAMIR) traditional open surgery (TOS) for gynecomastia in Chinese male patients, a total of 60 patients suffering from grade I II gynecomastia, evaluated by automated whole-breast ultrasound (AWBU), were recruited randomly divided into TOS MAMIR groups (each n = 30). The postoperative scar size, healing time, patient hospital stay, satisfaction, pain, complications including...
Kidney renal clear cell carcinoma (KIRC) with poor prognosis is the main histological subtype of carcinoma, accounting for more than 80% patients. Most patients are diagnosed at an advanced stage due to being asymptomatic early on. Advanced KIRC has extremely its inherent resistance radiotherapy and chemotherapy. Therefore, a comprehensive understanding molecular mechanisms development effective diagnostic therapeutic strategies urgently needed. In this study, we aimed identify...
Due to the existence of blood-brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy been shown have satisfactory effects solid tumors, and it is clinically instructive explore possibility glioma. We performed retrospective analysis RNA-seq data clinical information 1027 glioma patients, utilizing machine learning relationship between tyrosine metabolizing enzymes characteristics. In addition, we also assessed role immune microenvironment...
A new dammarane-type triterpene monoglucoside, named isoginsenoside-Rh(3), has been isolated from the fruits of Panax ginseng C. A. Mey, together with eight known analogs, ginsenoside-Rb(1), -Rb(2), -Rc, -Rd, -Re, -Rg(1), -Rh(1), -Rh(2). On basis chemical and physicochemical evidence, structure isoginsenoside-Rh(3) elucidated as 3-O-beta--glucopyranosyl-dammarane-(E)-20(22),24-diene-3beta,12beta-diol (1).