A5017638610- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Immune responses and vaccinations
- Drug Transport and Resistance Mechanisms
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Weed Control and Herbicide Applications
- Bacterial biofilms and quorum sensing
- Traditional Chinese Medicine Analysis
- High Altitude and Hypoxia
- Autophagy in Disease and Therapy
- Hospitality and Tourism Education
- Allelopathy and phytotoxic interactions
- Protein Hydrolysis and Bioactive Peptides
- Pesticide and Herbicide Environmental Studies
- Cruise Tourism Development and Management
- ATP Synthase and ATPases Research
- CAR-T cell therapy research
- Vibrio bacteria research studies
- melanin and skin pigmentation
- Biochemical effects in animals
Tianjin University
2023-2025
Xiamen University
2021-2024
Nanjing Medical University
2021-2024
Second Affiliated Hospital of Nanjing Medical University
2021-2024
Henan Academy of Agricultural Sciences
2024
Institute of Plant Protection
2024
Henan Agricultural University
2023
Universiti Tun Abdul Razak
2023
Guangzhou Building Materials Institute
2023
Nanjing University
2021
T helper type 2 (Th2) cytokine-activated M2 macrophages contribute to inflammation resolution and wound healing. This study shows that IL-4-primed exhibit a stronger response lipopolysaccharide stimulation while maintaining signature gene expression. Metabolic divergence between canonical non-canonical proinflammatory-prone (M2INF) occurs after the IL-4Rα/Stat6 axis. Glycolysis supports Hif-1α stabilization proinflammatory phenotype of M2INF macrophages. Inhibiting glycolysis blunts...
The prevalence of hypertension is increasing globally, while strategies for prevention and treatment remain limited. FG-4592 (Roxadustat) a potentially novel, orally active small-molecule hypoxia-inducible factor (HIF) stabilizer being used clinically to treat chronic kidney disease (CKD) anemia. In the present study, we evaluate effects on hypertension. an angiotensin II (Ang II) model, abolished hypertensive responses; prevented vascular thickening, cardiac hypertrophy, injury;...
Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein arginine methyltransferase 6 (PRMT6) highly expressed in cancer required for cell metabolism, tumorigenicity, cisplatin response PRMT6 regulated oxidative pentose phosphate pathway (PPP) flux glycolysis human by increasing activity 6-phospho-gluconate dehydrogenase (6PGD) α-enolase (ENO1). Furthermore,...
Early-activated CD8+ T cells increase both aerobic glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). However, whether how the augmentation of OXPHOS regulates differentiation effector cell remains unclear. Here, we found that C1qbp was intrinsically required for such in antiviral antitumor immune responses. Activated C1qbp-deficient failed to respiratory capacities, resulting diminished acetyl–coenzyme A as well elevated fumarate 2-hydroxyglutarate. Consequently,...
To perform their antiviral and antitumor functions, T cells must integrate signals both from the cell receptor (TCR), which instruct to remain quiescent or become activated, cytokines that guide cellular proliferation differentiation. In mature CD8 + cells, Themis has been implicated in integrating TCR cytokine signals. We investigated whether plays a direct role signaling cells. was required for IL-2– IL-15–driven mice vitro. Mechanistically, we found promoted activation of transcription...
Abstract This study was conducted to investigate the relationship between Acinetobacter baumannii biofilm formation and antibiotic resistance. Furthermore, effects of PAβN, a potential efflux pump inhibitor, on A. dispersion were tested, gene expression levels pumps determined mechanisms. A total 92 isolates from infected patients collected identified by multiplex PCR. The antimicrobial susceptibility clinical tested VITEK 2 COMPACT ® . Genotypes ERIC‐2 Biofilm detected crystal violet...
Pyroxasulfone (PYS) is an isoxazole herbicide favored for its high activity. However, the metabolic mechanism of PYS in tomato plants and response to are still lacking. In this study, it was found that seedlings had a strong ability absorb translocate from roots shoots. The highest accumulation apex tissue Using UPLC-MS/MS, five metabolites were detected identified plants, their relative contents different parts varied greatly. serine conjugate, DMIT [5, 5-dimethyl-4,...
Ursodeoxycholic acid (UDCA) is a naturally occurring, low-toxicity, and hydrophilic bile (BA) in the human body that converted by intestinal flora using primary BA. Solute carrier family 7 member 11 (SLC7A11) functions to uptake extracellular cystine exchange for glutamate, highly expressed variety of cancers. Retroperitoneal liposarcoma (RLPS) refers originating from retroperitoneal area. Lipidomics analysis revealed UDCA was one most significantly downregulated metabolites sera RLPS...
The residues of clomazone (Clo) can lead to phytotoxic symptoms such as foliar bleaching, reduced plant height, and decreased maize yields. Herbicide safener represent one the most economically efficient strategies for mitigating herbicide-induced damage.
At present, Guangzhou homestay industry is facing a bottleneck. Therefore, it particularly important to analyze the factors that influence competitiveness of rural homestays in Guangzhou, determine evaluation system competitiveness, and weight each factor. Based on Porter’s diamond theory, this paper analyzes summarizes influencing divides into 5 primary 34 secondary factors. The analytic hierarchy process (AHP) was used judgment matrix form results factor, show product characteristics...
<p>The paper indicates the traditional buildings in Dubai, analyzes influential factors of urban building styles Dubai from local policies, natural environment, and religious culture, reasons for architectural so as to pro-vide reference experience exploration modern buildings.</p>
The purpose of this study is to investigate the greater competitiveness rural homestay tourism among respondents, as well relationship between environmental factors, operator product characteristic marketing strategies, and customer satisfaction. With in Guangzhou research object, based on network evaluation spatial data, paper try explore homestay's method. corresponding system model was constructed for competitive estimates by analyzing development potential, Suggestions are put forward...
Abstract Trained immunity, or innate immune memory, is vital in inducing heterologous protection against infection. Type 2 cytokines such as IL-4 and IL-13 induce M2 macrophage differentiation, characterized by anti-inflammatory phenotype permitting inflammation resolution wound healing. Here we report that peritoneal macrophages isolated from OVA-allergen sensitized mice possessed both signatures a pro-inflammatory phenotype. Moreover, were more resistant to bacterial infection the...
Abstract T helper type 2 (Th2) cytokine-activated M2 macrophages play a major role in inflammation resolution and wound healing. Myriads of studies have demonstrated the anti-inflammatory feature macrophages. In present study, we report that IL-4-primed respond more robustly to subsequent LPS stimulation despite maintaining canonical signature gene expression. The non-canonical proinflammatory-prone (M2 INF ) diverge metabolically after common IL-4Ra/Stat6 axis. While Gln/α-KG/Jmjd3 axis is...
IL-4 induces alternative macrophage activation with anti-inflammatory features. Counterintuitively, LPS stimulation robust proinflammatory responses in IL-4-primed macrophages. Following the common IL-4Ra/Stat6 axis, canonical M2 and non-canonical M2INF diverge metabolically. While Gln/α-KG/Jmjd3 axis is indispensable for differentiation, glycolysis/Hif-1α critical IL-4-induced M2INF. The elevated glycolysis sustains Hif-1α stabilization pro-inflammatory phenotype of Inhibition blunts...