A5101511037- Wound Healing and Treatments
- RNA modifications and cancer
- Circular RNAs in diseases
- Pressure Ulcer Prevention and Management
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- RNA Research and Splicing
- Parathyroid Disorders and Treatments
- Cancer and Skin Lesions
- Breast Lesions and Carcinomas
- Drug Transport and Resistance Mechanisms
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- ATP Synthase and ATPases Research
- Advancements in Transdermal Drug Delivery
- Dermatologic Treatments and Research
- Protease and Inhibitor Mechanisms
- RNA and protein synthesis mechanisms
- Male Breast Health Studies
- Macrophage Migration Inhibitory Factor
- Skin Protection and Aging
Harbin Medical University
2009-2024
Second Affiliated Hospital of Harbin Medical University
2009-2024
Heilongjiang Academy of Sciences
2020
Abstract Refractory diabetic wounds can cause persistent inflammation and delayed healing due to hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs-exo) may promote skin wound healing, however, molecular mechanisms remains mysterious. We found significantly enhanced survival proliferation after hypoxia induction compared normoxia. Here, we aimed investigate if hypoxic exosomes (HypADSCs-exo) participate in adaptability accelerate healing. Based on...
Hepatocellular carcinoma (HCC) is a highly vascularized tumor with frequent extrahepatic metastasis. Active angiogenesis and metastasis are responsible for rapid recurrence poor survival of HCC. However, the mechanisms that contribute to remain unclear. Here we evaluate effects ATPase inhibitory factor 1 (IF1), an inhibitor mitochondrial H(+)-adenosine triphosphate (ATP) synthase, on HCC We found increased expression IF1 in human predicts disease after surgery. Patients who have large...
Kaempferol is a flavonoid that has been reported to exhibit antitumor activity in various malignant tumors. However, the role of kaempferol on cholangiocarcinoma (CCA) largely unknown. In this article, we found inhibited proliferation, reduced colony formation ability, and induced apoptosis HCCC9810 QBC939 cells vitro. Results from transwell assay wound-healing demonstrated significantly suppressed migration invasion abilities was decrease expression Bcl-2 increase expressions Bax, Fas,...
Breast cancer (BC) is the most common cause of death in women throughout world.Although microRNAs (miRNAs) have been identified as novel regulators carcinogenesis, there are still abundant hidden treasure needed to be excavated.In present study, we found that miR-519d expression was remarkably decreased both human BC tissues and MCF-7 cells.CCK8 5-Ethynyl-2′-deoxyuridine (EdU) assays were used evaluate cell proliferation.Wound-healing transwell performed for detection migration invasion.The...
Inhibition of cellular adaptation to hypoxia can cause persistent inflammation, thereby increasing tissue damage and complicating wound healing in diabetes patients. Regulating hypoxic environments help effective repair. Hypoxia-inducible factor (HIF)-1
Dysregulated expression of lncRNAs has been observed in various human complex diseases (including cancers) by recent transcriptional profiling studies, highlighting potentials as biomarkers for cancer diagnosis and prognosis. Despite some efforts have made to search novel lncRNA signature breast cancer, the prognostic value ER-positive patients still needs be systematically investigated. In this study, we analyzed profiles a large more than 600 with status from The Cancer Genome Atlas (TCGA)...
To analyze and compare prospectively the curative effects between mammotome-assisted minimally invasive resection (MAMIR) traditional open surgery (TOS) for gynecomastia in Chinese male patients, a total of 60 patients suffering from grade I II gynecomastia, evaluated by automated whole-breast ultrasound (AWBU), were recruited randomly divided into TOS MAMIR groups (each n = 30). The postoperative scar size, healing time, patient hospital stay, satisfaction, pain, complications including...
Aging is the leading cause of several degenerative diseases. Photoaging due to ultraviolet (UV) exposure accounts for more than 80% facial aging, which a complex and incompletely understood process. Here, we explored mechanisms skin photoaging increased chromatin accessibility in UVB-irradiated human dermal fibroblasts (UVB-HDFs). Especially, investigated key pathways inflammatory responses characterized by exons occupied active repressive marks. mRNA sequencing revealed changes expression...
Abstract Refractory diabetic wounds can cause persistent inflammation and delayed healing due to hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs-exo) may promote skin wound healing, however, molecular mechanisms remains mysterious. We found significantly enhanced survival proliferation after hypoxia induction compared normoxia. Here, we aimed investigate if hypoxic exosomes (HypADSCs-exo) participate in adaptability accelerate healing. Based on...
Objective To observe the effect of down-regulated expression Twist gene on growth and infiltration breast cancer cells.Methods The small interfering RNA (siRNA) vectors targeting were designed synthesized,and transfected into MDA-MB-231 cells.The levels mRNA protein detected by using reverse transcriptase-polymerase chain reaction (RT-PCR) Western blotting.Western blotting was used to detect genes about apoptosis.Methyl thiazol tetrazolium (MTT) assay flow cytometry apoptosis.Results which...
Objective To investigate whether Smad3 small interference RNA (siRNA) can in-hibit transforming growth factor (TGF)-β-induced MMP-9 gene expression in MDA-MB-231 cells. Meth-ods siRNA targeting Sroad3 was designed, synthesized, then transfected into cells and stimulated by TGF-β1 (1 μg/L). After 24 h of stimulation,Smad binding element (SBE) reporter activi-ties were measured a luciferase assay. stimulation, protein detected immunoblot analysis. 48 mRNA de-termined RT-PCR analysis...
<title>Abstract</title> Background:<bold> </bold>Sebaceous glands (SGs) are epidermal appendages that important constituents of fully functional skin. The reconstruction SGs is an integral part wound healing. Exosomes from adipose-derived stem cells (ADSC-EXO) accelerate healing by promoting the migration and proliferation fibroblasts keratinocytes. However, effects ADSC-EXO on largely unknown. Methods: In this study, three-dimensional scaffolds gelatin methacrylate (GelMA) hydrogel loaded...