A5103080911- Mesenchymal stem cell research
- Pressure Ulcer Prevention and Management
- Gastric Cancer Management and Outcomes
- Autophagy in Disease and Therapy
- Metastasis and carcinoma case studies
- Extracellular vesicles in disease
- Gastrointestinal Tumor Research and Treatment
- Wound Healing and Treatments
Second Affiliated Hospital of Harbin Medical University
2021-2024
Harbin Medical University
2021-2024
This study aimed to evaluate the efficacy and safety of neoadjuvant programmed cell death-1 (PD-1) inhibitors plus apatinib chemotherapy (PAC) in patients with locally advanced gastric cancer (LAGC).Seventy-three resectable LAGC were enrolled named PAC group (n=39) or (AC) (n=34) based on treatment they chose. Neoadjuvant therapy was administered a 21-day cycle for 3 consecutive cycles, after which surgery performed.The exhibited higher objective response rate than AC (74.4% vs. 58.8%,...
Abstract Refractory diabetic wounds can cause persistent inflammation and delayed healing due to hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs-exo) may promote skin wound healing, however, molecular mechanisms remains mysterious. We found significantly enhanced survival proliferation after hypoxia induction compared normoxia. Here, we aimed investigate if hypoxic exosomes (HypADSCs-exo) participate in adaptability accelerate healing. Based on...
Abstract Objective Our study aimed to assess the effects of Growth and differentiation factor 11 (GDF11) on function endothelial progenitor cells in middle-age individuals (EPCs-MA) isolated from mouse bone marrow explore mechanistic relationship between GDF11 age-related ALP impairment. Methods Bone marrow-derived EPCs were isolated, culture treatment. In vivo , mice model myocardial ischemia (MI) was induced by permanent ligation left anterior descending coronary artery (LAD) randomly...