A5100777985- Algal biology and biofuel production
- Nematode management and characterization studies
- MicroRNA in disease regulation
- Thermochemical Biomass Conversion Processes
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Aquaculture Nutrition and Growth
- Microbial Metabolic Engineering and Bioproduction
- Microbial Community Ecology and Physiology
- RNA Interference and Gene Delivery
- Entomopathogenic Microorganisms in Pest Control
- Fungal and yeast genetics research
- Electrochemical sensors and biosensors
- Biofuel production and bioconversion
- Advanced Nanomaterials in Catalysis
- Lignin and Wood Chemistry
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pesticide Residue Analysis and Safety
- RNA modifications and cancer
- Conducting polymers and applications
- Biochemical and biochemical processes
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Enzyme-mediated dye degradation
Shenzhen University
2016-2025
Yunnan University
2017-2025
Guangzhou Medical University
2013-2025
Second Affiliated Hospital of Guangzhou Medical University
2013-2025
Northwest A&F University
2023-2024
Wenzhou Medical University
2024
Dalian Medical University
2022-2024
Harbin Medical University
2009-2024
First Affiliated Hospital of Harbin Medical University
2023-2024
Nanjing Tech University
2023
Abstract Background As an important means of communication, exosomes play role in the development hepatocellular carcinoma (HCC). Methods Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into underlying mechanism miR-21 HCC. Results The detection miRNAs HCC showed that expression was positively correlated with level cells negatively its target genes PTEN, PTENp1 TETs. cell-derived could increase...
Strong substrate affinity and high catalytic efficiency are persistently pursued to generate high-performance nanozymes. Herein, with unique surface atomic configurations distinct d-orbital coupling features of different metal components, a class highly efficient MnFeCoNiCu transition high-entropy nanozymes (HEzymes) is prepared for the first time. Density functional theory calculations demonstrate that improved between metals increases electron density near Fermi energy level (EF ) shifts...
Microalgae are a kind of promising raw material for bioenergy production and carbon sequestration. To enhance cell growth efficiency, great efforts were made exploring the appropriate intensity quality light to improve synthesis value-added products. The aggregation-induced emission (AIE) (Astrazon Brilliant Red 4G), active converting blue-green red (630–680 nm), was first time applied in research achieve high fatty acid yield with considerable carbon–neutral ability. After 10...
Nematode-trapping (NT) fungi can form unique infection structures (traps) to capture and kill free-living nematodes and, thus, play a potential role in the biocontrol of nematodes. Arthrobotrys oligospora is representative species NT fungi. Here, we performed time course transcriptome sequencing (RNA-seq) analysis transcriptomes understand global gene expression levels A. during trap formation predation. We identified 5,752 differentially expressed genes, among which rac was significantly...
Abstract The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). aim here investigate the effects AQP4 SAE and reveal its underlying mechanism causing cognitive impairment. in vivo experimental results that peripheral blood patients up‐regulated, also cortical hippocampal tissue cecal ligation perforation (CLP) mouse brain has significant rise AQP4. Furthermore, data suggest deletion could attenuate learning memory...
The feasibility of producing biofuels and biochemicals from lignocellulosic biomass via the biochemical platform depends largely on advances in pretreatment hydrolysis technologies to obtain sugars cellulose hemicelluloses plant cell walls. This paper provides an overview merits challenges related developing biological processes modify lignin for facilitating subsequent enzymatic extraction sugars. Although it has so far attracted little attention due many inherent limitations, multiple...
Metastasis is responsible for the rapid recurrence and poor survival of malignancies. Epithelial-mesenchymal transition (EMT) has a critical role in metastasis. Increasing evidence indicates that EMT can be regulated by microRNAs (miRNAs). The aim this study was to investigate miR-26b modulating epithelial-mesenchymal hepatocellular carcinoma (HCC), as well identify its underlying mechanism action. expression level assessed multiple HCC cell lines (HepG2, MHCC97H, Hep3B, MHCC97L, HCCC9810,...
Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause cancer-related mortality in world. MicroRNAs (miRNAs) are small, noncoding RNAs that play essential roles various stages during cancer progression. The aim current study was to elucidate role miR-1269 pathogenesis HCC.The expression HCC cells tissues were determined by Real-time PCR analysis. Cell viability, colony formation anchorage-independent growth ability assays performed examine cell proliferative...
A growing amount of evidence supports that microRNA (miRNA) dysregulation is involved in cancer progression by directly downregulating multiple targets. Elucidating the underlying mechanism miRNA carcinogenesis may improve diagnostic and therapeutic strategies for malignancy. In current study, we found miR-105 expression was markedly downregulated both hepatocellular carcinoma (HCC) cell lines clinical HCC tissues, compared with normal human hepatocyte adjacent non-cancerous respectively....
Hepatocellular carcinoma (HCC) is one of the common malignancies, which highly metastatic and third cause cancer deaths in world. The invasion metastasis cells a multistep complex process mainly initiated by extracellular matrix (ECM) degradation. Aberrant expression microRNA has been investigated HCC shown to play essential roles during progression. In present study, we found that microRNA-324-5p (miR-324-5p) was downregulated both cell lines tissues. Ectopic miR-324-5p led reduction...
We have screened 11 isoquinoline derivatives and α-methylene-γ-butyrolactones using the 3-(4,5-dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HeLa HEK-293T cells. Compound 2 was identified as potential anticancer agent. To further improve its therapeutic potential, this agent incorporated into transferrin (Tf)-conjugated liposomes (LPs) for targeted delivery to tumor demonstrated Tf-LP-Compound superior antitumor activity compared non-targeted controls...
Widespread iron-bearing clay minerals are potential materials that can reduce and immobilize Cr(VI) as insoluble Cr2O3/Cr(OH)3. The kinetics of this process is controlled by various environmental factors, yet the effects such factors on transformation clays poorly understood. Herein, we report synergistic reduced nontronite (rNAu-2) environmentally prevalent organic ligands reduction under near-neutral pH conditions. presence belonging to α-hydroxyl or carbonyl carboxylates, tartrate,...
Engineering multimetallic nanocatalysts with the entropy-mediated strategy to reduce reaction activation energy is regarded as an innovative and effective approach facilitate efficient heterogeneous catalysis. Accordingly, conformational entropy-driven high-entropy alloys (HEAs) are emerging a promising candidate settle catalytic efficiency limitations of nanozymes, attributed their versatile active site compositions synergistic effects. As proof nanozymes (HEzymes) concept, elaborate...
MicroRNAs (miRNAs) are regulatory small non-coding RNAs that can regulate gene expression by binding to elements, such as the promotor 5'UTR, mainly in 3'UTR of mRNA. One miRNA targets many mRNAs, which be regulated miRNAs, leading a complex metabolic network. In our study, we found level miR-590-5p is higher human hepatocellular carcinoma cell line HepG2 than normal L02. Downregulation inhibited proliferation and invasion cells (HCCs). We also showed TGF-beta RII, has been regarded...