A5101812052- Genetics, Aging, and Longevity in Model Organisms
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Nematode management and characterization studies
- Antifungal resistance and susceptibility
- Peroxisome Proliferator-Activated Receptors
- Pain Mechanisms and Treatments
- Global Cancer Incidence and Screening
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Sphingolipid Metabolism and Signaling
- Calcium signaling and nucleotide metabolism
- Sperm and Testicular Function
- Fungal and yeast genetics research
- Teacher Education and Leadership Studies
- Bioactive natural compounds
- Sirtuins and Resveratrol in Medicine
- Educational Technology and Pedagogy
- Education Methods and Practices
- Cannabis and Cannabinoid Research
- Entomopathogenic Microorganisms in Pest Control
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
Hefei University of Technology
2021-2025
Shanghai Pulmonary Hospital
2018-2024
Guangdong Ocean University
2024
Tongji University
2018-2024
Kunming Medical University
2012-2023
Yunnan University
2013-2023
Chengdu University of Traditional Chinese Medicine
2023
Shanghai East Hospital
2021
Sun Yat-sen University
2020
Fifth Affiliated Hospital of Sun Yat-sen University
2020
Background Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults explored mechanisms underlying inhibitory effects on cells. Methodology/Principal Findings Murine were treated with (1, 5, 10 µM) and/or LPS (5 µg/ml). Nitric oxide (NO) prostaglandin E2 (PGE2) measured by Griess reagent ELISA. The mRNA protein levels proinflammatory...
Temperature is a key factor for determining the lifespan of both poikilotherms and homeotherms. It believed that animals live longer at lower body temperatures. However, precise mechanism remains largely unknown. Here, we report autophagy serves as boost longevity low temperature in nematode Caenorhabditis elegans. The adiponectin receptor AdipoR2 homolog PAQR-2 signaling detects drop augments biosynthesis two ω-6 polyunsaturated fatty acids, γ-linolenic acid arachidonic acid. These acids...
Abstract Background Although the adiponectin signalling exerts exercise‐mimicking effects, whether this pathway contributes to anti‐ageing benefits of physical exercise has not been established yet. Methods Swim training and wheel running were used measure lifespan in nematode Caenorhabditis elegans skeletal muscle quality mice, respectively. Muscle weight, fibre cross‐sectional area (CSA) myonuclei number evaluate mass. RNA sequencing (RNA‐Seq) analysis exercised mice was study underlying...
Abstract Ferroptosis is a novel form of programmed cell death which can exacerbate lung injury in septic acute respiratory distress syndrome (ARDS). Alveolar macrophages, crucial innate immune cells, play pivotal role the pathogenesis ARDS. Ferritinophagy process ferritin degradation mediated by nuclear receptor coactivator 4 (NCOA4) releases large amounts iron ions thus promoting ferroptosis. Recent evidence revealed that inhibiting macrophage ferroptosis effectively attenuate pulmonary...
Abstract Animals often experience periods of nutrient deprivation; however, the molecular mechanisms by which animals survive starvation remain largely unknown. In nematode Caenorhabditis elegans , nuclear receptor DAF-12 acts as a dietary and environmental sensor to orchestrate diverse aspects development, metabolism, reproduction. Recently, we have reported that together with co-repressor DIN-1S is required for tolerance promoting fat mobilization. this report, found genetic inactivation...
Metagenomic next-generation sequencing (mNGS) is an effective diagnostic method for infectious diseases, however, its clinical utility tuberculosis (TB) diagnosis remains to be demonstrated.A total of 322 bronchoalveolar lavage fluid (BALF) samples were collected from 311 suspected and confirmed pulmonary TB patients tested by mNGS, acid-fast bacillus (AFB) smear microscopy, Xpert® MTB/RIF (Xpert), mycobacterium culture bacterial/fungal culture. Diagnostic performance mNGS was compared with...
Nonalcoholic fatty liver disease (NAFLD) results from an abnormal accumulation of lipids within hepatocytes, and is commonly associated with obesity, insulin resistance, hyperlipidemia. Metformin used to treat type 2 diabetes mellitus and, in recent years, it was found play a potential role the amelioration NAFLD. However, mechanisms underlying protective effect metformin against NAFLD remain largely unknown. Transcription factor EB (TFEB) master transcriptional regulator lysosomal...
Nematode-trapping fungi live mainly as saprobes in soil environments. When encountering nematodes, these become 'carnivorous' and develop specialized trapping devices to attack their hosts for extracting nutrients, especially nitrogen source. Thus, nematode-trapping are model organisms understanding the molecular mechanism of switch between saprobic parasitic phases pathogen life cycles. Arthrobotrys oligospora, one best-studied fungi, lives a saprobe. In presence A.oligospora enters stage...
Abstract Background There is an urgent need to better understand the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for that disease 2019 (COVID-19) continues cause considerable morbidity and mortality worldwide. This paper was differentiate COVID-19 from other infectious diseases such as avian-origin influenza A (H7N9) (H1N1) virus infections. Methods We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2 ( n = 83),...
Invasive candidiasis (IC) is one of the leading causes death among immunocompromised patients. Because limited effective therapy treatment options, prevention IC through vaccine an appealing strategy. However, how to induce generation direct candidacidal antibodies in host remains unclear. Gpi7 mutant C. albicans avirulent strain that exposes cell wall β-(1,3)-glucans. Here, we found vaccination with gpi7 could protect mice against invasive caused by and non-albicans Candida spp. The...
Non-alcoholic fatty liver disease (NAFLD) is a major subtype worldwide, commonly associated with insulin resistance and obesity. NAFLD characterized by an excessive hepatic lipid accumulation, as well steatosis. Fenofibrate peroxisome proliferator-activated receptor α agonist widely used in clinical therapy to effectively ameliorate the development of NAFLD, but its mechanism action incompletely understood. Here, we found that fenofibrate dramatically modulate gut microbiota composition...
Postherpetic neuralgia (PHN) is the most common complication of herpes zoster. Methylene blue (MB) an inhibitor nitric oxide synthesis with potentially analgesic and anti-inflammatory properties. Studies have demonstrated that thoracic paravertebral single MB injection effective in treating chronic pain. However, there are rare reports efficacy continuous infusion for pain management PHN patients. The purpose this study was to evaluate therapeutic effects on PHN. A total 104 patients were...
“Xuebijing Injection” (XBJ) is a traditional Chinese medicine and has been wildly used in the treatment of sepsis China. However, few studies have reported use XBJ with acute lung injury (ALI). This study aimed to investigate therapeutic efficacy against sepsis-induced ALI. Generally total 27 mice were equally randomized into three groups: sham group was given saline before operation. A received cecal ligation puncture (CLP) operation only. sepsis+XBJ group, XBJ, injected at 72, 48, 24 h CLP...
At present, population-based cancer registries were not well established and epidemiologic data for limited at the province level in China. Using available mortality cancer, estimation model of lung was to provide profile population 31 provincial regions China 2008.Based on coverage accuracy provinces, methods used produce estimates fall into 1 3 categories: directly; a developed calculate annual change rate based historical current data; relative frequency combining with all sites estimate...
Fenofibrate is widely used in clinical therapy to effectively ameliorate the development of non-alcoholic fatty liver disease (NAFLD); however, its specific molecular mechanism action remains largely unknown. MicroRNAs (miRNAs) are key mediators regulating endoplasmic reticulum (ER) stress during NAFLD, and deregulation miRNAs has been demonstrated NAFLD pathophysiology. The present study aimed identify whether fenofibrate could influence miRNA expression investigate lipid metabolism...
Non-alcoholic fatty liver disease (NAFLD) is a major global health concern with increasing prevalence, lack of currently available effective treatment options; thus, the investigation novel therapeutic approaches necessary. The study aimed to investigate outcomes and mechanisms action Fagopyrum dibotrys extract (FDE) in high-fat diet (HFD)-induced mouse model obesity. findings showed that FDE supplementation attenuated glucose tolerance, insulin resistance (IR), hepatic steatosis, abnormal...
It has been reported that ascorbic acid inhibits non-alcoholic fatty liver disease partially by activating β-oxidation. However, little is known about the mechanism of acid-mediated lipid synthesis. Western blot, qRT-PCR and immunofluorescent staining were used to determine if can regulate expression X receptor α (LXRα) AMP-activated protein kinase (AMPKα), which are key regulators lipogenic genes. In hepatocytes, decreased cellular accumulation. Mechanistically, inhibited genes for...
This paper explores the design, implementation, and evaluation of Integrated English 3 blended course, which integrates online learning through massive open courses (MOOCs) face-to-face classroom instruction. Guided by production-oriented approach, course aims to improve students’ language proficiency intercultural communication skills. It employs a variety teaching methods, including self-study, task-based learning, collaborative group work, foster student engagement promote output. The...
Objective To establish an osteoradionecrosis of jaws (ORNJ) rat model which could be used to simulate ORNJ at different clinical stages, according the new diagnostic standards. Methods Thirty six male SD rats were divided into 6 groups randomly. For group a1, b1 and c1, left mandible each weas irradiated doses 7.0 Gy for 5 fractions, equivalent total 70 Gy. Group a0, b0 c0 sham irradiated, serving as control groups. Six weeks after irradiation, in a0 a1 sacrificed, meanwhile,...