A5034832683- Autophagy in Disease and Therapy
- Amyotrophic Lateral Sclerosis Research
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Metabolomics and Mass Spectrometry Studies
- Parkinson's Disease Mechanisms and Treatments
- Calpain Protease Function and Regulation
- Acupuncture Treatment Research Studies
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Sirtuins and Resveratrol in Medicine
- Cancer Immunotherapy and Biomarkers
- Atrial Fibrillation Management and Outcomes
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Pneumonia and Respiratory Infections
- Reproductive Biology and Fertility
- Metabolism, Diabetes, and Cancer
- Wound Healing and Treatments
- Adenosine and Purinergic Signaling
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Chongqing Medical University
2009-2024
Children's Hospital of Chongqing Medical University
2023-2024
Xiamen University
2013-2024
China Agricultural University
2024
Xi'an Jiaotong University
2011-2022
Kunming Medical University
2021
First Affiliated Hospital of Anhui Medical University
2001-2020
Anhui Medical University
2001-2020
Affiliated Hospital of Guizhou Medical University
2020
Abstract Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function GSDMC has not been clearly described. Herein, we demonstrate that metabolite α-ketoglutarate (α-KG) induces pyroptosis through caspase-8-mediated cleavage GSDMC. Treatment with DM-αKG, cell-permeable derivative α-KG, elevates ROS levels, leads to oxidation plasma membrane-localized receptor DR6. Oxidation DR6 triggers its endocytosis, and then recruits both pro-caspase-8...
Uncontrolled bleeding and infection can cause significant increases in mortalities. Hydrogel sealants have attracted extensive attention for their ability to control bleeding. However, because interfacial water is a formidable barrier strong surface bonding, challenge remains finding product that offers robust tissue adhesion combined with anti-infection properties. Inspired by the adhesive mechanism of biofilm mussels, we report novel dual bionic hydrogel (DBAH) based on chitosan grafted...
COVID-19 has drawn global intensive attention. We analyzed the duration of viral shedding and total time from illness onset to discharge in groups. This important implications for making decisions isolation discharged patients provide guidance hospitalization with severe COVID-19.
Abstract Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis negatively remains unclear. Here, we demonstrate that mannose, hexose, inhibits GSDME-mediated activating AMP-activated protein kinase (AMPK). Mechanistically, mannose metabolism in the hexosamine biosynthetic pathway increases levels metabolite N -acetylglucosamine-6-phosphate (GlcNAc-6P), which binds AMPK to facilitate phosphorylation LKB1. Activated then...
Osteocalcin, a synthetic osteoblast-specific protein, has recently emerged as an important regulator of energy metabolism, but the underlying mechanisms are not fully understood. In present study, mice fed high-fat diet and receiving osteocalcin showed reduced body weight gain, less fat pad improved insulin sensitivity well increased expenditure compared with vehicle. Meanwhile, endoplasmic reticulum (ER) stress, defective signaling, mitochondrial dysfunction induced by obesity were also...
To examine the efficiency of exclusive enteral nutrition (EEN) in relieving inflammatory bowel stricture patients with Crohn's disease (CD).Patients CD usually develop strictures due to transmural edema intestinal wall, which can potentially be managed conservative medical treatment. Previous studies showed that EEN therapy could induce clinical remission through its anti-inflammation effect.We achieved a prospective observational study. were preliminarily differentiated from fibrous one,...
We report a case of 75-year-old woman diagnosed with severe coronavirus disease 2019 (COVID-19) complicated by acute cerebral infarction. The patient was admitted to our hospital on 5 February 2020 COVID-19. On 20 2020, she concomitant infarction <italic>via</italic> head computed tomography (CT) and deep vein thrombosis in both lower limbs. After symptomatic supportive treatments, the discharged 13 March 2020. She will comply quarantine for another 2 weeks receive rehabilitation training...
The osteoblast-specific secreted molecule osteocalcin behaves as a hormone-regulating glucose and lipid metabolism, but the role of in cardiovascular disease (CVD) is not fully understood. In present study, we investigated effect on autophagy endoplasmic reticulum (ER) stress secondary to diet-induced obesity vascular tissue mice cell models clarified intracellular events responsible for osteocalcin-mediated effects. evidences showed that intermittent injections fed high-fat diet were...
Nonalcoholic fatty liver disease (NAFLD) results from an abnormal accumulation of lipids within hepatocytes, and is commonly associated with obesity, insulin resistance, hyperlipidemia. Metformin used to treat type 2 diabetes mellitus and, in recent years, it was found play a potential role the amelioration NAFLD. However, mechanisms underlying protective effect metformin against NAFLD remain largely unknown. Transcription factor EB (TFEB) master transcriptional regulator lysosomal...
Abstract Myocarditis has emerged as a rare but lethal immune checkpoint inhibitor (ICI)‐associated toxicity. However, the exact mechanism and specific therapeutic targets remain underexplored. In this study, we aim to characterise transcriptomic profiles based on single‐cell RNA sequencing from ICI‐related myocarditis. Peripheral blood mononuclear cell (PBMC) samples were collected four groups for sequencing: (1) patients with newly diagnosed lung squamous carcinoma before treatment (Control...
Objective . Progranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable directly affecting the insulin signaling pathway. This study aimed to investigate correlation between PGRN diabetics with microvascular complications. Methods serum levels glucose metabolism related substance were measured 84 diabetic patients or without microangiopathies 12 health persons. Further analyses different stages conducted. Results Serum...
Progranulin (PGRN) is a secreted protein that has recently emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity. We report here serum PGRN concentrations were significantly higher in patients with metabolic syndrome (MS) than subjects without MS correlated positively body mass index, waist circumference, fasting insulin, plasma glucose, glycated hemoglobin A1c, triglyceride, homeostasis model assessment resistance, inversely related to high-density...
Biocompatible and antimicrobial wound dressings are important biomaterials for tissue adhesion healing. Hydrogels derived from natural polyamino acids ideal dressing because of their good water solubility, biocompatibility, biodegradability. In this study, we introduce poly(amino acid)–based hydrogels as a new type The composite were water-soluble ε-polylysine γ-poly(glutamic acid) cross-linked by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide N-hydroxy-succinimide. gelation is attributed to...
Curcumin, a polyphenol isolated from the plant Curcuma longa, displays chemotherapeutic and chemopreventive effects in diverse cancers, including colorectal cancer. A mono-carbonyl analogue B63 was synthesized through several chemical modifications of basic structure curcumin to increase its biological activity bioavailability. In vitro assays showed potent anti-proliferative on colon cancer cells (about 2 fold more effective than based IC50). treatment also induced significant necrosis,...
Single-nucleotide polymorphisms (SNPs) in CDKAL1 have been associated with the development of type 2 diabetes (T2D). catalyzes 2-methylthio modification adenosine at position 37 tRNALys(UUU). A deficit this causes aberrant protein synthesis, and is impairment insulin secretion both mouse model human. However, it unknown whether T2D-associated SNPs are downregulation by regulating gene expression. Here, we report a specific splicing variant termed CDKAL1-v1 that markedly lower individuals...
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in regulation sensitivity autophagy remain elusive. In this study, we aimed to address direct effects vivo evaluate potential interaction impaired autophagic disorders hepatic resistance. We found that mice treated with 21 days exhibited tolerance imbalance well defective signaling. Furthermore, treatment TNF receptor (TNFR)-1 blocking...
Abstract Osteocalcin has been considered to be an important regulator of energy metabolism in type 2 diabetes mellitus (T2DM). However, the mechanism underlying involvement uncarboxylated osteocalcin vascular complications T2DM is not fully understood. In present study, we analyzed potential correlations between and macro- or microangiopathic subjects with tested impact on insulin resistance human umbilical vein endothelial cells (HUVECs). The results showed that serum levels were lower...
In this study, novel bio-inspired in situ hydrogels as tissue adhesives and hemostatic materials were designed prepared based on ɛ-polylysine-grafted poly(ethylene glycol) tyramine via enzymatic cross-linking. The cross-linked method enabled fast gelation within seconds, which facilitated its therapeutic applications. By changing the cross-linking conditions, storage modulus of could be tunable mechanical strength influenced adhesiveness hydrogels. Besides, showed fine network structures...