A5100402719- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Pancreatic function and diabetes
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Respiratory viral infections research
- Retinal Diseases and Treatments
- Radiation Therapy and Dosimetry
- Child and Adolescent Health
- Phytochemistry and Biological Activities
- Respiratory and Cough-Related Research
- Essential Oils and Antimicrobial Activity
- Glaucoma and retinal disorders
- Dermatology and Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Traditional Chinese Medicine Studies
- Nausea and vomiting management
- Tea Polyphenols and Effects
- Inflammasome and immune disorders
- Acute Lymphoblastic Leukemia research
Center for Excellence in Brain Science and Intelligence Technology
2025
Chinese Academy of Sciences
2025
ShanghaiTech University
2025
Army Medical University
2020-2025
Southwest Hospital
2010-2025
Huazhong University of Science and Technology
2024-2025
Central Hospital of Wuhan
2024-2025
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Fruit wastes are one of the main sources municipal waste. In order to explore potential fruit as natural resources bioactive compounds, antioxidant potency and total phenolic contents (TPC) lipophilic hydrophilic components in (peel seed) 50 fruits were systematically evaluated. The results showed that different residues had diverse variation was very large. Furthermore, compounds identified quantified, catechin, cyanidin 3-glucoside, epicatechin, galangin, gallic acid, homogentisic...
Edible macro-fungi are widely consumed as food sources for their flavors and culinary features. In order to explore the potential of a natural resource bioactive compounds, antioxidant properties polysaccharide contents 49 edible from China were evaluated systematically. A positive correlation between capacity total phenolic content indicated that compounds could be main contributors capacities these macro-fungi. Furthermore, many such gallic, homogentisic, protocatechuic, p-hydroxybenzoic...
Abstract Development of the mammalian lung is predicated on cross-communications between two highly interactive tissues, endodermally derived epithelium and mesodermally pulmonary mesenchyme. While much attention has been paid for epithelium, mesenchyme, partly due to lack specific tractable markers remains under-investigated. The mesenchyme from lateral plate mesoderm principal recipient Hedgehog (Hh) signaling, a morphogenetic network that regulates multiple aspects embryonic development....
Novel sunscreen products based on bioadhesive/gel systems that can prevent the skin penetration behaviors of UV filters have attracted increasing attention in recent years. However, integration is very difficult to achieve and control wet surface under sweaty/dynamic physiological conditions, resulting functional failure. Herein, we demonstrated fabrication a novel dual-network hydrogel (DNHS) poly-γ-glutamic acid (γ-PGA) tannic (TA), which prominent protection properties across broad UVA...
Hepatic fibrosis is chronic liver damage with many causes that has a relatively high death rate. The current study showed long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5), microRNA-23a (miR-23a), and phosphatase tensin homolog (PTEN) play important roles in the pathological process of hepatic but have unclear regulatory mechanism. This aimed to investigate lncRNA GAS5, miR-23a, PTEN stellate cell (HSC) activation. We used carbon tetrachloride (CCl4) intraperitoneal...
With the rapid development and high therapeutic efficiency biosafety of gas-involving theranostics, hydrogen medicine has been particularly outstanding because gas (H2), a microbial-derived gas, potent anti-oxidative, anti-apoptotic, anti-inflammatory activities in many disease models. Studies have suggested that H2-enriched saline/water alleviates colitis murine models; however, underlying mechanism remains poorly understood. Despite evidence demonstrating importance microbial economy,...
Recently, the addition of nanoparticles (NPs) has been proposed as a new strategy to enhance effect radiotherapy particularly in treatment aggressive tumors such glioblastoma. The physical processes involved radiosensitisation by have well studied although further understanding its biological impact is still lacking, and this includes localisation these NPs target cells. Most studies were performed with tagged fluorescent markers. However, presence markers can influence uptake localisation....
Recently, we developed a novel tea cultivar 'Ziyan' with distinct purple leaves. There was significant correlation between leaf color and anthocyanin pigment content in the A allocation of metabolic flow for B-ring trihydroxylated anthocyanins catechins observed. Delphinidin, cyanidin, pelargonidin (88.15 mg/100 g FW total) but no other pigments were detected 'Ziyan', delphinidin (70.76 FW) particularly predominant. An analysis catechin eight cultivars indicated that exhibits preference...
A new methylene-linked flavan-3-ol dimer, bis(8-epicatechinyl)methane (1), was isolated from the pericarps of Litchi chinensis Sonn. (Sapindaceae), together with dehydrodiepicatechin (2), proanthocyanidin A1 (3), A2 (4), (-)-epicatechin (5), 8-(2-pyrrolidinone-5-yl)-(-)-epicatechin (6), 8-C-β-D-glucopyranoside (7), naringenin 7-O-(2,6-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (8), and rutin (9). It first report compound 2 as a natural product compounds 6-8 this species. Compounds 1, 2,...
Aim: This study aimed at developing antibody-functionalized gold nanoparticles (AuNPs) to selectively target cancer cells and probing their potential radiosensitizing effects under proton irradiation. Materials & methods: AuNPs were conjugated with cetuximab (Ctxb–AuNPs). Ctxb–AuNP uptake was evaluated by transmission electron microscopy atomic absorption spectroscopy. Radioenhancing effect assessed using conventional clonogenic assay. Results conclusion: Ctxb–AuNPs specifically bound...
Abstract Objective Asthma is a chronic inflammatory disease of the airways with gender differences in prevalence after puberty. Recent studies have reported relationship between asthma and endometriosis, possibly related to immune response mechanisms, but evidences are limited inconsistent. Herein, this research aimed investigate association endometriosis based on representative population United States (U.S.) provide some reference for further exploration mechanism difference asthma....
Small metallic nanoparticles are proposed as potential nanodrugs to optimize the performances of radiotherapy. This strategy, based on enrichment tumours with amplify radiation effects in tumour, aims at increasing cytopathic effect while healthy tissue is preserved, an important challenge Another major cause radiotherapy failure radioresistance certain cancers. Surprisingly, use overcome has not, best our knowledge, been extensively investigated. The mechanisms have studied using...
Utilizing Swept source optical coherence tomography angiography (SS-OCTA) investigates the changes in vascular characteristics of choriocapillaris and larger layers, including Sattler's Haller's macular region young myopia patients, order to Enhance our comprehension underlying mechanisms pathogenesis myopia. A retrospective analysis was performed on 103 adults (154 eyes) that underwent SS-OCTA. Axial lengths (AL) were measured, 64 eyes with AL < 26.5 mm as non-high (NHM) 90 ≥ high (HM)....
Extended care based on self-efficacy theory to elderly patients with intertrochanteric fractures will provide data reference optimize the plan of these patients, reduce patients' concurrent mental diseases, and improve prognosis. To analyze value extended nursing in older fractures. Older (n = 88) admitted our hospital between January 2021 December 2024 were randomly divided into two groups - control group 44, routine nursing) observation via balloting treated for 12 weeks. The state, pain...
The mechanisms through which general anesthetics induce loss of consciousness remain unclear. Previous studies have suggested that dorsal raphe nucleus serotonergic (DRN 5-HT ) neurons are involved in inhalational anesthesia, but the underlying neuronal and synaptic not well understood. In this study, we investigated role DRN propofol-induced anesthesia larval zebrafish (sex undetermined at developmental stage) using a combination vivo single-cell calcium imaging, two-photon laser ablation,...
In this study, novel bio-inspired in situ hydrogels as tissue adhesives and hemostatic materials were designed prepared based on ɛ-polylysine-grafted poly(ethylene glycol) tyramine via enzymatic cross-linking. The cross-linked method enabled fast gelation within seconds, which facilitated its therapeutic applications. By changing the cross-linking conditions, storage modulus of could be tunable mechanical strength influenced adhesiveness hydrogels. Besides, showed fine network structures...
The functional sweetener, d-tagatose, is commonly transformed from galactose by l-arabinose isomerase. To make use of a much cheaper starting material, lactose, hydrolization, and isomerization are required to take place collaboratively. Therefore, single-step method involving β-d-galactosidase was explored for d-tagatose production. two vital genes, gene (lacZ) isomerase mutant (araA') were extracted separately Escherichia coli strains incorporated into E. simultaneously. This gave us...