A5103257017- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Landslides and related hazards
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Geotechnical Engineering and Underground Structures
- Genomics and Chromatin Dynamics
- Civil and Geotechnical Engineering Research
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Tendon Structure and Treatment
- Ferroptosis and cancer prognosis
- Geotechnical Engineering and Soil Stabilization
- Bone Metabolism and Diseases
- Grouting, Rheology, and Soil Mechanics
- Rock Mechanics and Modeling
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- Geotechnical Engineering and Soil Mechanics
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- TGF-β signaling in diseases
Jinan University
2011-2025
Hubei University
2025
National Institutes of Health
2013-2024
Guilin Medical University
2014-2024
Chengdu Surveying Geotechnical Research Institute
2012-2024
Kunming Municipal Hospital of Traditional Chinese Medicine
2024
Tongren Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
National Cancer Institute
2013-2023
Center for Cancer Research
2015-2023
This paper presents findings from an investigation of the large-scale construction solid waste (CSW) landslide that occurred at a landfill Shenzhen, Guangdong, China, on December 20, 2015, and which killed 77 people destroyed 33 houses. The involved 2.73×106 m3 CSW affected area about 1100 m in length 630 maximum width, making it largest world. this disaster used combination unmanned aerial vehicle surveillance multistage remote-sensing images to reveal increasing volume shifting shape slope...
Genetic aberrations, such as gene amplification, deletions, and loss of heterozygosity, are hallmarks cancer thought to be major contributors the neoplastic process. Established cell lines have been primary in vitro vivo models for more than 2 decades; however, few extensively characterized at genomic level. Here, we present a high-resolution genome-wide chromosomal alteration expression analyses five most commonly used glioma compare findings with those observed 83 human gliomas. Although...
Abstract Gliomas are the most common type of primary brain tumors in adults and a significant cause cancer-related mortality. Defining glioma subtypes based on objective genetic molecular signatures may allow for more rational, patient-specific approach to therapy future. Classifications gene expression data have been attempted past with varying success only some concordance between studies, possibly due inherent bias that can be introduced through use analytic methodologies make priori...
Tumor cell invasion is the principal cause of treatment failure and death among patients with malignant gliomas. Connective tissue growth factor (CTGF) has been previously implicated in cancer metastasis various tumors. We explored mechanism CTGF-mediated glioma infiltration examined potential therapeutic targets. Highly infiltrative patient-derived tumor–initiating or tumor stem cells (TIC/TSCs) were harvested used to explore a CTGF-induced signal transduction pathway via luciferase...
Abstract White lupin (Lupinus albus) adapts to phosphorus deficiency (−P) by the development of short, densely clustered lateral roots called proteoid (or cluster) roots. In an effort better understand molecular events mediating these adaptive responses, we have isolated and sequenced 2,102 expressed sequence tags (ESTs) from cDNA libraries prepared with RNA at different stages root development. Determination overlapping regions revealed 322 contigs (redundant copy transcripts) 1,126...
Background: CUR is a promising drug candidate based on its good bioactivity, but use of potentially restricted because poor solubility and bioavailability. Aim: The aim this study was to prepare an aqueous formulation curcumin nanosuspension (CUR-NS) improve change in vivo behavior. Methods: CUR-NS prepared by high-pressure homogenization method. Drug state evaluated powder X-ray diffraction. Pharmacokinetics biodistribution after intravenous administration rabbits mice were studied....
Despite progress in the determination of miR interactions, their regulatory role cancer is only beginning to be unraveled. Utilizing gene expression data from 27 glioblastoma samples we found that mere knowledge physical interactions between specific mRNAs and miRs can used determine associated allowing us identify 626 involving 128 putatively modulate 246 mRNAs. Experimentally determining miRs, an over-representation over(under)-expressed with various predicted mRNA target sequences. Such...
Age is a powerful predictor of survival in glioblastoma multiforme (GBM) yet the biological basis for difference clinical outcome mostly unknown. Discovering genes and pathways that would explain age-specific could generate opportunities novel therapeutics GBM. Here we have integrated gene expression, exon microRNA copy number alteration, SNP, whole exome sequence, DNA methylation data sets cohort GBM patients The Cancer Genome Atlas (TCGA) project to discover signatures at transcriptional,...
Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, mechanism which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed establishes targetable vulnerability in IDH1-mutated cancers.We investigated wild-type (GSC827, GSC923, GSC627, and GSC711) (IDH1R132C- IDH1R132H-transduced U87, U251; MGG152, TS603 cells). We analyzed stability transcriptional activity of NRF2 cells. The...
Abstract To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, high‐density simple sequence repeat (SSR) genetic linkage map was developed BC 1 F population of hirsutum × . The comprised 2,292 loci covered 5115.16 centiMorgan (cM) AD genome, with an average marker interval 2.23 cM. Of order for 1,577 common on this new map, 90.36% agrees well D genome map. Compared five published SSR maps, 53.14% were newly discovered in Twenty‐six...
Abstract Purpose: Glioblastoma (GBM) is highly resistant to treatment, largely due disease heterogeneity and resistance mechanisms. We sought investigate a promising drug that can inhibit multiple aspects of cancer cell survival mechanisms become an effective therapeutic for GBM patients. Experimental Design: To TG02, agent with known penetration the blood–brain barrier, we examined effects as single in combination temozolomide, commonly used chemotherapy GBM. human cells syngeneic mouse...
We report an observation of a pressure-induced breakdown the three-dimensional Dirac semimetal (3D-DSM) state in $\mathrm{C}{\mathrm{d}}_{3}\mathrm{A}{\mathrm{s}}_{2}$, evidenced by series situ high-pressure synchrotron x-ray diffraction and single-crystal transport measurements. find that $\mathrm{C}{\mathrm{d}}_{3}\mathrm{A}{\mathrm{s}}_{2}$ undergoes structural phase transition from metallic tetragonal space group $I{4}_{1}/acd$ to semiconducting monoclinic $P{2}_{1}/c$ at critical...
Abstract Articular cartilage injury or defect is a common disease and mainly characterized by degradation because of chondrocyte inflammation. By now, there are no effective drugs methods to protect articular from degradation. Icariin (ICA) typical flavonoid compound extracted Epimedii Folium with anti-inflammatory bone-protective effects. Our previous studies demonstrate that ICA up-regulates HIF-1α expression glycolysis in chondrocytes maintains phenotype. As another member HIFs family,...
Black titanium dioxide (TiO2) nanoparticles have attracted great attention due to their application in photothermal therapy (PTT). However, single-mode phototherapy has the risk of recurrence, and high-dose laser usually imposed improve PTT performance can bring a potential threat security. Here, polydopamine (PDA)-coated black TiO2 (b-P25@PDA) with core-shell structure were synthesized for enhanced PTT; then, synergistic nanoprobes (b-P25@PDA-Ce6 (Mn)) constructed by coupling chlorin e6...
Abstract Stem cell therapy has been extensively studied to improve heart function following myocardial infarction; however, its therapeutic potency is limited by low rates of engraftment, survival, and differentiation. Here, we aimed determine the roles β-catenin/Oct4 signaling axis in regulation long-term survival angiogenesis peripheral blood mesenchymal stem cells (PBMSCs). These were obtained from rat abdominal aortic blood. We showed that β-catenin promotes self-renewal, antiapoptotic...