A5079152412- Advancements in Transdermal Drug Delivery
- Synthesis and properties of polymers
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Epoxy Resin Curing Processes
- Silicone and Siloxane Chemistry
- Renal cell carcinoma treatment
- Drug Solubulity and Delivery Systems
- Cancer Diagnosis and Treatment
- Coastal and Marine Dynamics
- Plant Disease Resistance and Genetics
- Urological Disorders and Treatments
- Dermatology and Skin Diseases
- Electrospun Nanofibers in Biomedical Applications
- Ocean Waves and Remote Sensing
- Genital Health and Disease
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Herpesvirus Infections and Treatments
- Polymer composites and self-healing
- Pharmacological Effects of Natural Compounds
- Advanced biosensing and bioanalysis techniques
- Retinal Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Genetic Mapping and Diversity in Plants and Animals
China Agricultural University
2023-2025
Qingdao University
1998-2025
Wenzhou Medical University
2016-2025
Taian City Central Hospital
2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wuhan Polytechnic University
2025
Yuhuangding Hospital
2012-2024
Fudan University
2022-2024
Wuhan University of Science and Technology
2024
University of Chinese Academy of Sciences
2024
Gray leaf spot (GLS), caused by the fungal pathogens Cercospora zeae-maydis and zeina, is a major foliar disease of maize worldwide (Zea mays L.). Here we demonstrate that ZmWAKL encoding cell-wall-associated receptor kinase-like protein causative gene at quantitative resistance locus against GLS. The
Background: CUR is a promising drug candidate based on its good bioactivity, but use of potentially restricted because poor solubility and bioavailability. Aim: The aim this study was to prepare an aqueous formulation curcumin nanosuspension (CUR-NS) improve change in vivo behavior. Methods: CUR-NS prepared by high-pressure homogenization method. Drug state evaluated powder X-ray diffraction. Pharmacokinetics biodistribution after intravenous administration rabbits mice were studied....
The interest in nanosuspensions by the pharmaceutical industry is increasing given several nanosuspension products currently on market for poorly soluble drugs. In this study, a novel dosage form curcumin (CUR), CUR (CUR-NS), was successfully prepared high pressure homogenization to improve CUR's cytotoxicity, as well its application via intravenous injection. Characterization of CUR-NS evaluated morphology, size, zeta potential, solubility, dissolution rate, and crystal state drug....
The aims of this study were to design the formulation curcumin (CUR) liposomes coated with N-trimethyl chitosan chloride (TMC) and evaluate in vitro release characteristics vivo pharmacokinetics bioavailability TMC-coated CUR rats. structure synthesized TMC was examined by infrared spectroscopy, presence trimethyl groups, proton nuclear magnetic resonance indicating high degree substitution quaternization (65.6%). Liposomes, composed soybean phosphotidylcholine, cholestrol, D-α-tocopheryl...
Glucagon-like peptide 1 (GLP-1), a kind of gut hormone, is used in the treatment type 2 diabetes (T2D). Emerging evidence indicates that GLP-1 has anti-inflammatory activity. Chronic inflammation adipose tissue obese individuals cause insulin resistance and T2D. We hypothesized analogue therapy patients with T2D could suppress inflammatory response macrophages, therefore inhibit resistance. Our results showed agonist (exendin-4) not only attenuated macrophage infiltration, but also inhibited...
Background: Certain drugs can cause intrinsic or extrinsic tooth discoloration, which is not only a clinical issue but also an esthetic problem. However, limited investigations have focused on drug-induced discoloration. The present work aimed to determine the causing discoloration and estimate their risks of Methods: An observational, retrospective, pharmacovigilance analysis was conducted, in we extracted adverse event (AE) reports involving by using data US Food Drug Administration’s...
Abstract Plant height is an important agronomic trait that affects high-density tolerance and lodging resistance. However, the regulators their underlying molecular mechanisms controlling plant in maize remain understudied. Here, we report knockout mutants of calcium-dependent protein kinase gene ZmCPK39 ( -KO) exhibit dramatically reduced height, characterized by shorter internodes a slight decrease node numbers. Furthermore, identified ZmCPK39-interacting protein, knotted-related homeobox...
With the aim to enhance dissolution rate and oral bioavailability of quercetin, a poorly water-soluble drug, quercetin loaded nanosuspension (QT-NS) was fabricated by tandem nano-precipitation (NP) high pressure homogenization (HPH) method. The formulation optimized screening different stabilizers. Characterization original QT powder QT-NS carried out transmission electron microscopy scanning microscopy, X-ray diffraction (XRD) tests. presented sphere-like shape under with an average...
Connectivity is a fundamental requirement for vehicular ad hoc networks (VANETs) to secure reliable information dissemination. not guaranteed in the case of traffic sparsity and low market penetration networked vehicles. Therefore, it essential examine connectivity condition before deploying VANETs. The probabilistic distribution intervehicle spacing plays crucial role study connectivity. It quite often previous studies assume priori distribution. This paper has studied this issue...
Gray leaf spot, northern blight and southern are three of the most destructive foliar diseases affecting maize (Zea mays L.). Here we identified a gene, ZmCPK39, that encodes calcium-dependent protein kinase negatively regulates quantitative resistance to these diseases. The ZmCPK39 allele in resistant line displayed significantly lower pathogen-induced gene expression than susceptible line. A marked decrease abundance mitigated phosphorylation degradation transcription factor ZmDi19. This...
Transferrin receptor (TfR) is frequently over-expressed on epithelial cancer cells, TfR-targeted liposomes, therefore, can potentially improve tumor cell uptake, cytotoxicity, and treatment efficacy of the encapsulated drug. The liposomes loaded with docetaxel were prepared by polycarbonate membrane extrusion composition hydrogenated soy phosphatidylcholine (HSPC)/egg (PC)/cholesterol (Chol)/methoxy-polyethylene glycol (mPEG)2,000-distearoyl-phosphatidylethanolamine (DSPE)...