A5029836519- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Advancements in Transdermal Drug Delivery
- Pharmacological Effects of Natural Compounds
- Dendrimers and Hyperbranched Polymers
- Magnolia and Illicium research
- Surfactants and Colloidal Systems
- Drug Solubulity and Delivery Systems
- Natural product bioactivities and synthesis
- Nail Diseases and Treatments
- Antimicrobial agents and applications
- Nanocomposite Films for Food Packaging
- Phytochemistry and Biological Activities
- RNA Interference and Gene Delivery
- Essential Oils and Antimicrobial Activity
- Polymer Nanocomposites and Properties
- Antifungal resistance and susceptibility
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Phytochemistry and biological activity of medicinal plants
- Atherosclerosis and Cardiovascular Diseases
- E-commerce and Technology Innovations
- Sesquiterpenes and Asteraceae Studies
- Dysphagia Assessment and Management
University of Jinan
2014-2024
Zero to Three
2020
GTx (United States)
2019
Nankai University
2017
Shandong First Medical University
2013
Background: Curcumin (CUR) has been linked with antioxidant, anti-inflammatory, antimicrobial, anti amyloid, and antitumor effects, but its application is limited because of low aqueous solubility poor oral bioavailability. Methods: To improve bioavailability water solubility, we synthesized two series poly (ε-Caprolactone)-poly (ethylene glycol)-poly (ε-Caprolactone) triblock copolymers by ring-opening polymerization glycol) ε-Caprolactone, stannous 2-ethylhexanoate as the catalyst....
Inflammation and excessive reactive oxygen species production are the main reason for slow wound healing, which necessitates an efficient therapy in clinic.
Purpose: To improve curcumin’s pharmacokinetic, in vitro cytotoxicity and release property.Methods: A novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer was synthesized through O-alkylation, basic hydrolysis ring-opening polymerization reaction with glycol), epichlorohydrin ɛ-caprolactone as raw materials. Its structure characterized by 1H-NMR GPC. The copolymer’s hemolysis micellar encapsulation for curcumin thin-film hydration were studied....
Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of low aqueous solubility poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading (Cur-NPs) which could improve release property curcumin. In the present study, we further evaluated anti-atherosclerotic effect in apolipoprotein E −/− mice. Our results demonstrated that...
Ketoconazole is a broad spectrum imidazole antifungal drug. For the treatment of superficial fungal infections with ketoconazole, it needs to be permeated deep skin layers. In order develop topical formulation ketoconazole for improving its deposition and water-solubility, ketoconazole-loaded methoxy poly (ethylene glycol)-b-poly (δ-valerolactone) micelles were developed through thin-film hydration method. Particle size, drug loading capacity, infrared X-ray diffraction drug-loaded...
Honokiol-loaded micelles were prepared by emulsion-solvent evaporation procedure when oligochitosan-pluronic conjugate (CS-F127) as carrier. Differential scanning calorimetry (DSC) indicated that honokiol existed in amorphous form it was encapsulated into the with 87.54 ± 1.52% of encapsulation efficiency (EE) and 12.51 0.22% drug loading (DL) capacity. The water-solubility increased to 1.46 mg/mL, being >27-folds higher than pure honokiol. vitro release study demonstrated a slow sustained...
In this study, an α-linolenic acid modified pluronic F127-<italic>block</italic>-chitosan (F127-(CS-LNA)<sub>2</sub>) copolymer was synthesized to prepare topical amphotericin B (AMB)-loaded micelles (AMB-M) <italic>via</italic> a dialysis technique.
Background: Curcumin is a natural hydrophobic product showing anticancer activity. Many studies show its potential use in the field of cancer treatment due to safety and efficiency. However, application limited low water-solubility poor selective delivery cancer. Keywords: Curcumin, folic acid, poly (ethylene glycol), ε-caprolactone, Y-shaped, copolymer.