A5100389728- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Curcumin's Biomedical Applications
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Bioactive Natural Diterpenoids Research
- Advancements in Transdermal Drug Delivery
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Plant Toxicity and Pharmacological Properties
- Bryophyte Studies and Records
- Nail Diseases and Treatments
- Antimicrobial agents and applications
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- Sesquiterpenes and Asteraceae Studies
- Glutathione Transferases and Polymorphisms
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Advanced Drug Delivery Systems
- Plant biochemistry and biosynthesis
- Dendrimers and Hyperbranched Polymers
- Ubiquitin and proteasome pathways
University of Jinan
2014-2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
University of Florida
2023
Second Military Medical University
2017
Bayer (Germany)
2013
University of Wisconsin–Madison
2013
The tetracyclic carbon skeleton of hainanolidol and harringtonolide was efficiently constructed by an intramolecular oxidopyrylium-based [5 + 2] cycloaddition. An anionic ring-opening strategy developed for the cleavage ether bridge in 8-oxabicyclo[3.2.1]octenes derived from Conversion cycloheptadiene to tropone realized a sequential [4 cycloaddition, Kornblum–DeLaMare rearrangement, double elimination. biomimetic synthesis also confirmed.
Inflammation and excessive reactive oxygen species production are the main reason for slow wound healing, which necessitates an efficient therapy in clinic.
Purpose: To improve curcumin’s pharmacokinetic, in vitro cytotoxicity and release property.Methods: A novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer was synthesized through O-alkylation, basic hydrolysis ring-opening polymerization reaction with glycol), epichlorohydrin ɛ-caprolactone as raw materials. Its structure characterized by 1H-NMR GPC. The copolymer’s hemolysis micellar encapsulation for curcumin thin-film hydration were studied....
Developing effective therapies against multiple myeloma (MM) is an unresolved challenge. Phosphatidylinositol-3-kinase (PI3K) activation may be associated with tumor progression and drug resistance, inhibiting PI3K can induce apoptosis in MM cells. Thus, targeting of predicted to increase the susceptibility anticancer therapy. The lead compound a novel class inhibitors, BAY80-6946 (IC50=0.5 nM PI3K-α), was highly efficacious four different cell lines, where it induced significant antitumoral...
Compounds that target tumor epigenetic events are likely to constitute a prominent strategy for anticancer treatment. Histone deacetylase inhibitors (HDACis) have been developed as prospective candidates in drug development, and currently, many of them under clinical investigation. We assessed the efficacy now hydroxamate-based HDACi, YF-343, triple-negative breast cancer development studied its potential mechanisms.YF-343 was estimated novel HDACi by screening kit. The biological effects...
Malignant hyperthermia (MH) is a fatal with high mortality, which usually occurs during induction of general anesthesia. Dantrolene sodium wonder drug currently used for treating malignant hyperthermia. However, preparing, storing, and maintaining dantrolene are crucially expensive, thus making it financially unsatisfactory difficult clinicians to acquire in time. Monitoring patients' condition closely intervening promptly when early signs occur can effectively prevent the from worsening win...
The manipulation of ferroptosis in cancer cells is a possible therapeutic technique that has been investigated for use the treatment cancer. Consequently, ferroptosis-inducing medications have recently received increased interest therapy. In this research, we assessed anticancer efficacy 14β-hydroxy- 3β-(β-D-Glucopyranosyloxy)-5α-bufa-20,22-dienolide (HTB50-2), natural product derived from plant Helleborus thibetanus Franch, Triple-Negative Breast Cancer (TNBC). Moreover, also studied its...
The monounsaturated fatty acid 7(E)-9-keto-hexadec-7-enoic (1) and three structurally related analogues with different oxidation states degrees of unsaturation (2–4) were discovered from a marine benthic cyanobacterial mat collected Delta Shoal, Florida Keys. Their structures elucidated using NMR spectroscopy mass spectrometry. structure 1 contained an α,β-unsaturated carbonyl system, key motif required for the activation Keap1/Nrf2−ARE pathway that is involved in antioxidant phase II...
In this study, nanometer WO 3 powder was uniformly dispersed into the Cu 2 SnSe by ball milling process, and /Cu thermoelectric composite prepared spark plasma sintering (SPS). The results showed that nano-WO particles were mainly distributed in grain boundary of matrix, growth inhibited. addition could enhance electrical conductivity , while Seebeck coefficient increased slightly for 0.4% composite. thermal not decreased until content exceeded 1.6%. highest figure merit ZT 0.177 achieved at...
Liverworts, widely used as traditional Chinese medicine, are a rich source of structurally diverse secondary metabolites with intriguing biological activities. Given that diterpenoids present in liverwort species possess striking scaffoldings and considering the absence any previous review on this subject, we an updated analysis diterpenes liverworts along their activities based literature dated from 1997 to present. This comprehensive effort is expected lay foundation for further research...