A5101616473- Chronic Myeloid Leukemia Treatments
- Physiological and biochemical adaptations
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- Food composition and properties
- Eosinophilic Disorders and Syndromes
- Neurobiology and Insect Physiology Research
- Plant Genetic and Mutation Studies
- Quinazolinone synthesis and applications
- Agriculture, Soil, Plant Science
- Advanced biosensing and bioanalysis techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Radiation Effects and Dosimetry
- Protein Structure and Dynamics
- Mechanics and Biomechanics Studies
- Psychological and Temporal Perspectives Research
- Signaling Pathways in Disease
- Amyotrophic Lateral Sclerosis Research
- Effects of Radiation Exposure
- Microbial Metabolic Engineering and Bioproduction
- Polysaccharides Composition and Applications
- Nitrogen and Sulfur Effects on Brassica
- Psychological Well-being and Life Satisfaction
- Advanced Chemical Sensor Technologies
- Acute Lymphoblastic Leukemia research
Anhui Agricultural University
2025
East China University of Science and Technology
2008-2025
St. Jude Children's Research Hospital
2007-2021
Rutgers, The State University of New Jersey
2015
Temple University
1994
Protein kinases intrinsically sample a number of conformational states with distinct catalytic and binding activities. We used nuclear magnetic resonance spectroscopy to describe in atomic-level detail how Abl kinase interconverts between an active two discrete inactive structures. Extensive differences key structural elements the give rise multiple intrinsic regulatory mechanisms. The findings explain oncogenic mutants can counteract inhibitory mechanisms constitutively activate kinase....
The aim of this study was to investigate the effects different combinations molasses levels and slow-release urea on Holstein fattening bulls. Sixty bulls a similar age, weight, health status were randomly divided into four groups fifteen each. All treatments as follows: (1) basic diet group (CON); (2) 2% (LMU); (3) 4% (MMU); (4) 6% (HMU). results showed that MMU had an outstanding performance, with 13.3% increase in average daily weight gain compared control group, significant decrease feed...
In this work, Pichia pastoris was applied to produce human insulin by a simple procedure. The synthesized precursor (ILP) gene inserted into pPIC9K obtain secretary expression plasmid pPIC9K/ILP. GS115 transformed pPIC9K/ILP and the high expresser screened. 16 L fermentor, production 3.6 g/L. Insulin precursor, purified one-step chromatography, converted transpeptidation. yield of processing procedure from reached up 70%. vivo assay showed that biological activity produced recombinant 28.8 U/mg.
ABSTRACT Rapid filtration assays were used to characterize glutamate/cation uptake in brush-border membrane vesicles from the larval midgut of lepidopteran Manduca sexta. At pH 10.5, which is close physiological M. sexta, an inwardly directed K+ gradient stimulated glutamate uptake, suggesting that was symported. Gradients Na+ or Li+ less effective. Neither Rb+ nor Cs+ uptake. Anion-specificity pronounced: accumulation maximum only slightly higher with thiocyanate (SCN−) than Cl−, although...
Glossoscopy is an important part of Traditional Chinese Medicine (TCM). To analyze the tongue properties objectively, we need extract region from images. This paper presents a method to segment images based on kernel FCM (Fuzzy Cluster means). Firstly pre-processed by gray-level integral projection. Secondly features were extracted form feature vector which contained texture, color, location and other information. Then, according vectors, pixels clustering whose parameters decided proposed...
In this study, mechanomyography (MMG) was used to evaluate the effectiveness and sensibility of degree muscle fatigue. The preprocessed MMG signal decomposed by 6-scale discrete wavelet transform (DWT) acquire coefficients each scale. low frequency scale 3, 4, 5 (A3, A4, A5) were reconstruct signals respectively. Frequency-domain features extracted, linear regression equations established make comparisons, which indicated that 15-62Hz bands play a major role in spectrum shifting lower...
ABSTRACT The effects of amino acid sidechain length, substituent position and chirality on acid/K+ symport have been examined in rapid filtration experiments brush-border membrane vesicles prepared from larval Manduca sexta midgut. Cis-inhibition trans-stimulation protocols were used to examine the analogs uptake alanine, phenylalanine, leucine lysine, which are cotransported with K+ by a zwitterionic symporter at high pH characteristic midgut vivo. was found translocate both L-...
Studies of conformational features fragments SNase(111-143) and SNase(118-143) segment E122-K136 in 1-139 fragment (SNase139) suggest that the high intrinsic helical propensity can drive fold into a stable helix only when segments V111-H121 L137-D143 flanked on staphylococcal nuclease (SNase) have folding. Keywords: SNase(111-143), fragment, C-terminal sub-domain, helix-forming tendency, ensemble interconverting conformations
Summary In marine seismic exploration, exist of receiver ghost influences the frequency band and imaging result seriously. Generation is owing to that cable must be towed below sea surface, so depth plays an important part in data quality. this paper, based on real we analysis characteristic variable plane slant terms signal noise ratio, frequency, wavelet, also make comparison deghosting among various cables. Analysis conclusions can provide references for geometry design a processor's...