A5017576191- Protein Tyrosine Phosphatases
- Calcium Carbonate Crystallization and Inhibition
- Graphene research and applications
- Vitamin K Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Bone Tissue Engineering Materials
- PI3K/AKT/mTOR signaling in cancer
- Liver physiology and pathology
- Thermal properties of materials
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Collagen: Extraction and Characterization
- Cytokine Signaling Pathways and Interactions
- Fiber-reinforced polymer composites
- Bone health and osteoporosis research
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- HIV Research and Treatment
- Vibration Control and Rheological Fluids
- 14-3-3 protein interactions
- TGF-β signaling in diseases
- Cancer-related Molecular Pathways
- Advanced Sensor and Energy Harvesting Materials
- Carbon Nanotubes in Composites
- RNA and protein synthesis mechanisms
Westlake University
2025
Zhejiang University
2020-2024
Ruijin Hospital
2023-2024
Shanghai Jiao Tong University
2022-2024
Inner Mongolia University
2023-2024
Moderna Therapeutics (United States)
2023
Dimagi (United States)
2023
Leidos Biomedical Research Inc. (United States)
2020-2022
Frederick National Laboratory for Cancer Research
2018-2022
Hebei University of Technology
2022
Highly thermally conductive carbon fibers (CFs) have become an important material to meet the increasing demand for efficient heat dissipation. To date, high thermal conductivity has been only achieved in specific pitch-based CFs with crystallinity. However, obtaining graphitic crystallinity and beyond pitch-CFs remains a grand challenge. Here, 2D-topology-seeded graphitization method is presented mediate topological incompatibility by seeding 2D graphene oxide (GO) sheets into...
Abstract Macroscopic fibres assembled from two-dimensional (2D) nanosheets are new and impressing type of fibre materials besides those one-dimensional (1D) polymers, such as graphene fibres. However, the preparation property-enhancing technologies these follow 1D polymers by improving orientation along axis, leading to non-optimized microstructures low integrated performances. Here, we show a concept bidirectionally promoting assembly order, making achieve synergistically improved...
Abstract Graphene fiber (GF), a macroscopic one‐dimensional assembly of individual graphene sheets, promises both extraordinary mechanical performance and superior multifunctionality. However, the properties are still limited due to unfavorable crystalline structures, especially induced by wrinkled conformations graphene. A plasticization spinning strategy is presented achieve GF with high strength electrical/thermal conductivity. Adjusting interlayer space from 1.2 1.8 nm intercalating...
Electrorheological (ER) technology is an advanced based on ER effects. The most common material in electrorheological fluid (ERF), which a type of smart soft material. viscosity ERF reversibly adjustable by applied electric field. A new electroresponsive material, elastomer (ERE), derivative ERFs, has attracted wide attention due to its advantages not precipitating and easy packaging. materials are widely mechanical engineering their tunable characteristics, fast response, low energy...
The mineral component of bone, dentin and calcified parts avian tendon, hydroxyapatite (HAP), has non-stoichiometric composition (idealized as Ca10(PO4)6(OH)2), plate-like morphology nanometer size. This unique crystal contributes to the physico-chemical biochemical properties bone. Thus, understanding mechanism for controlled growth HAP nanocrystals is significant in study bone biomineralization. Previous studies have shown that acidic non-collagenous proteins (ANCPs), which are enriched...
The larger size of graphene sheets should intuitively generate higher overall properties their macroscopic materials. However, this intuitive notion still remains ambiguous. Here, we uncover that the wrinkle formation causes counterintuitive predicament in In model oxide assembled papers, reveal giant aggravates wrinkles and more microvoids, causing negative effect mechanical strength. A major microscopic origin is skin wrinkling drying process, behavior follows a general rule deformation an...
Natural materials teach that mechanical dissipative interactions relieve the conflict between strength and toughness enable fabrication of strong yet tough artificial materials. Replicating natural nacre structure has yielded rich biomimetic materials; however, stronger interlayer dissipation still waits to be exploited extend performance limits Here, we introduce entanglement as a new mechanism fabricate entangled with superior toughness, across molecular nanoscale structures. The graphene...
Subcutaneous injections of hormone triiodothyronine in rats resulted peak blood levels at 24 hr with return to baseline by 96 hr. The stimulated a liver regeneration response that resembled timing and magnitude DNA synthesis (peak, hr) induced 40% hepatic resection. principal proliferation was hepatocytes. Although there were some temporal differences from the gene expression transforming growth factor-alpha, factor-beta, c-Ha-ras are known follow partial hepatectomy, overall profile these...
Particle size is a key parameter that must be measured to ensure reproducible production of cellulose nanocrystals (CNCs) and achieve reliable performance metrics for specific CNC applications. Nevertheless, measurements CNCs are challenging due their broad distribution, irregular rod-shaped particles, propensity aggregate agglomerate. We report an interlaboratory comparison (ILC) tests transmission electron microscopy (TEM) protocols image acquisition analysis. Samples were prepared on TEM...
Abstract Highly thermally conductive graphitic film (GF) materials have become a competitive solution for the thermal management of high-power electronic devices. However, their catastrophic structural failure under extreme alternating thermal/cold shock poses significant challenge to reliability and safety. Here, we present first investigation into mechanism GF during cyclic liquid nitrogen shocks (LNS), which reveals bubbling process characterized by “permeation-diffusion-deformation”...
Biological materials exhibit fascinating mechanical properties for intricate interactions at multiple interfaces to combine superb toughness with wondrous strength and stiffness. Recently, strong interlayer entanglement has emerged replicate the powerful dissipation of natural proteins alleviate conflict between toughness. However, designing in a network needs be further explored. Here, we modulate by introducing interactions, including hydrogen ionic bonding, achieve ultrahigh performance...
The multikinase inhibitor sorafenib is the first oral agent to show activity against human hepatocellular carcinoma (HCC). Apoptosis has been shown be induced in HCC by several agents, including as well naturally occurring K vitamins (VKs). As few nontoxic agents have growth, we evaluated of and VKs, both independently together on growth cells vitro vivo. We found that when VK was combined with sorafenib, concentration required for inhibition substantially reduced. Conversely, enhanced...
The unique, plate-like morphology of hydroxyapatite (HAP) nanocrystals in bone lends to the hierarchical structure and functions bone. Proteins enriched phosphoserine (Ser-OPO3) glutamic acid (Glu) residues have been proposed regulate crystal morphology; however, atomic-level mechanisms remain unclear. Previous molecular dynamics studies addressing biomineralization used force fields with limited benchmarking, especially at water/mineral interface, often sampling for binding free energy...
Abstract The self-assembly of lipid bilayer membranes to enclose functional biomolecules, thus defining a “protocell,” was seminal moment in the emergence life on Earth and likely occurred at micro-environment mineral-water interface. Mineral-lipid interactions are also relevant biomedical, industrial technological processes. Yet, no structure-activity relationships (SARs) have been identified predict mineral surfaces. Here we examined influence minerals survival vesicles composed single...
Compound 5 (Cpd 5) or 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone, is an inhibitor of protein phosphatase Cdc25A and causes persistent activation extracellular signal-regulated kinase (ERK) cell growth inhibition. To study the mechanism(s) by which ERK phosphorylation might induce inhibition, we used Cpd as a tool to examine its effects on activity CREB (cAMP response element-binding protein) transcription factor in Hep3B human hepatoma cells. We found that activity, including DNA...
A characteristic defect occurs in rat and human hepatocellular carcinoma (HCC) resulting a loss of function the vitamin K-dependent enzyme gamma-glutamyl-carboxylase tumor but not underlying liver. This causes secretion elevated levels immature or des-gamma-carboxylated form prothrombin, which is used as marker HCC. We investigated whether, using defined conditions growing HCC cell lines tissue culture, addition naturally occurring vitamins K1 K2 synthetic K3 could influence prothrombin....
Bone is a hierarchical biocomposite material in which collagen fibril matrix self-assembled three-dimensional (3-D) pseudohexagonal array controls many important processes mineralization such as providing the pathways by calcium and phosphate species are delivered template for earliest nucleation sites, determining spatial distribution of mineral topology binding associated non-collagenous proteins. However, structural characteristics molecules remain unclear at atomic level. Here we...