A5066354708- Amphibian and Reptile Biology
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Species Distribution and Climate Change
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Plant Virus Research Studies
- Wildlife Ecology and Conservation
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Lepidoptera: Biology and Taxonomy
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Bat Biology and Ecology Studies
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Mosquito-borne diseases and control
- Protein Kinase Regulation and GTPase Signaling
- Genetic diversity and population structure
- Pancreatic and Hepatic Oncology Research
- Sphingolipid Metabolism and Signaling
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
Zhengzhou University
2025
Shanghai Institute of Nutrition and Health
2019-2024
University of Chinese Academy of Sciences
2017-2024
Affiliated Hospital of Southwest Medical University
2024
Xijing Hospital
2024
Air Force Medical University
2024
Nanjing University of Chinese Medicine
2024
Jilin Province Tumor Hospital
2008-2024
Fosun Pharma (China)
2021-2023
Chinese Academy of Sciences
2014-2023
Tregs not only keep immune responses to autoantigens in check, but also restrain those directed toward pathogens and the commensal microbiota. Control of peripheral homeostasis by relies on their capacity accumulate at inflamed sites appropriately adapt local environment. To date, factors involved control these aspects Treg physiology remain poorly understood. Here, we show that canonical Th2 transcription factor GATA3 is selectively expressed residing barrier including gastrointestinal...
Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting express little GATA3, which is increased IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting cells. that have upregulated produce IL-13, but not IL-4, response to plus activator an antigen-independent, NF-kappaB-dependent, cyclosporin A (CsA)-resistant manner. Similarly, Th17 IL-17A IL-1beta STAT3 Th1 IFNgamma IL-18 STAT4 inducer. Thus, each effector Th cell produces cytokines...
Dephosphorylating RNA polymerase II Transcription in metazoans requires coordination of multiple factors to control the progression polymerases and integrity their products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed protein phosphatase 2A (PP2A) core enzyme multisubunit endonuclease Integrator. Structural functional studies show that INTAC functions as noncanonical PP2A holoenzyme dephosphorylates C-terminal domain attenuate transcription. This study...
Trace elements play important roles in human health, but little is known about their functions humoral immunity. Here, we show an role for iron inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared iron-normal controls. Mice with deficiency also attenuated T-dependent or T-independent antigen-specific responses. essential proliferation; both α-ketoglutarate inhibition could...
Adipose tissue stroma contains a population of mesenchymal stem cells, which support repair when administered to damaged tissues, in large part through secreted trophic factors. We directly tested the ability media collected from cultured adipose-derived cells (ASCs) protect neurons rat model brain hypoxic-ischemic (HI) injury. Concentrated conditioned medium ASCs (ASC-CM) or control was infused jugular vein neonatal Sprague-Dawley rats subjected HI The ASC-CM either 1 hour before 24 hours...
People using prescription medication often concurrently take herbal supplements. In a case report, the anticoagulant effect of warfarin decreased after patients consumed ginseng.To evaluate interactions between American ginseng and warfarin.Randomized, double-blind, placebo-controlled trial.General Clinical Research Center, University Chicago, Illinois.20 healthy patients.In this 4-week study, 20 received for 3 days during weeks 1 4. Beginning in week 2, were assigned to receive either or...
By using a whole-genome oligonucleotide microarray, designed based on known and predicted indica rice genes, we investigated transcriptome profiles in developing leaves panicles of superhybrid LYP9 its parental cultivars 93-11 PA64s. We detected 22,266 expressed genes out 36,926 total set collectively from 7 tissues, including at seedling tillering stages, flag booting, heading, flowering, filling stage. Clustering results showed that the F1 hybrid's expression resembled those lines more...
Whole-genome resequencing is still a costly method to detect genetic mutations that lead altered forms of proteins and may be associated with disease development. Since the majority disease-related single nucleotide variations (SNVs) are found in protein-coding regions, we propose identify SNVs expressed exons human genome using recently developed RNA-Seq technique. We 12 176 10 621 SNVs, respectively, Jurkat T cells CD4(+) from healthy donor. Interestingly, our data show one copy TAL-1...
Growth factor independent 1 (Gfi-1), a transcriptional repressor, is transiently induced during T cell activation. Interleukin (IL) 4 further induces Gfi-1, resulting in optimal Th2 expansion. We report second important function of Gfi-1 CD4 cells: prevention alternative differentiation by cells, and inhibition naive cells to either Th17 or inducible regulatory (iTreg) cells. In Gfi1−/− the Rorc, Il23r, Cd103 loci showed histone 3 lysine trimethylation modifications that were lacking...
A new species of the microhylid frog genus Microhyla is described from Fanjing Mountain Guizhou Province, China. Phylogenetic analyses based on DNA sequences mitochondrial 12S rRNA, 16S rRNA and COI genes supported as an independent lineage, closely related to M. beilunensis, mixtura okinavensis. The uncorrected genetic distance gene between its closest congeners okinavensis are 3.5%, 4.6% respectively. distinguished by a combination following morphological characters: (1) body medium size...