A5079186811- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- T-cell and Retrovirus Studies
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Nitric Oxide and Endothelin Effects
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Fermentation and Sensory Analysis
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Coconut Research and Applications
- Sirtuins and Resveratrol in Medicine
- HER2/EGFR in Cancer Research
- Advanced Chemical Sensor Technologies
- Cytokine Signaling Pathways and Interactions
- Seaweed-derived Bioactive Compounds
- Microbial Metabolites in Food Biotechnology
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
Nantong Tumor Hospital
2017-2025
Harvard University
2010-2024
Dana-Farber Cancer Institute
2013-2024
Nantong University
2024
Rice Institute
2011-2021
University of Louisville
2007-2021
Boston Children's Hospital
2009-2019
Beijing University of Chinese Medicine
2015
Howard Hughes Medical Institute
2015
National Institutes of Health
2012
Abstract This multicenter, phase II study (NCT03872791) aims to evaluate the efficacy and safety of anti-PD-L1/CTLA-4 bispecific antibody KN046 combined with nab-paclitaxel in first-line treatment patients metastatic triple-negative breast cancer (TNBC). The primary endpoints included objective response rate (ORR) duration (DoR), secondary progression-free survival (PFS), overall (OS) rate, safety, correlation PD-L1 status clinical efficacy. trial met pre-specified endpoints. 27 female were...
Abstract Background The standard first‐line treatment for human epidermal growth factor receptor 2 (HER2)‐positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti‐HER2 bispecific antibody, docetaxel in HER2‐positive cancer. Methods open‐label, single‐arm, phase II enrolled patients with 19 centers across China from December 30, 2019 May 27, 2021. Patients were administered KN026...
B1 or B2? The BCR decides Immunological B cells are generally divided into two major subsets. B2 generate specific antibodies against foreign antigens in secondary lymphoid organs. cells, found predominantly the peritoneal and pleural cavities, instead produce “natural” as part of innate immune system. Two models to explain this split exist: “lineage model,” wherein both subsets have distinct progenitors, “selection which fates directed by different cell antigen receptors (BCRs). Graf et al....
BAFF-R-dependent activation of the alternative NF-kappaB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression NIK and deletion TRAF3 gene are implicated human multiple myeloma. We show that mouse lymphocytes amplifies peripheral numbers a manner, whereas uncoupling from TRAF3-mediated control causes maximal p100 processing dramatic hyperplasia BAFF-R-independent cells. controls signaling by increasing protein levels its negative regulator...
d Genetic loss of TRAF3 is associated with
Significance Epstein–Barr virus (EBV) drives human B cell proliferation and transformation, but also potent T surveillance. When surveillance fails, EBV-driven malignancies arise. cells can be stimulated/expanded on EBV-transformed for adoptive therapy. Clinical data point to the therapeutic importance of CD4 cells, perhaps through direct cytotoxicity; mechanism underlying such an activity remains unknown. Previous studies show that signaling by EBV oncoprotein LMP1 enhances antigen...
Compound 5 (Cpd 5) or 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone, is an inhibitor of protein phosphatase Cdc25A and causes persistent activation extracellular signal-regulated kinase (ERK) cell growth inhibition. To study the mechanism(s) by which ERK phosphorylation might induce inhibition, we used Cpd as a tool to examine its effects on activity CREB (cAMP response element-binding protein) transcription factor in Hep3B human hepatoma cells. We found that activity, including DNA...
Medullary thymic epithelial cells function as antigen-presenting in negative selection of self-reactive T cell clones, a process essential for the establishment central self-tolerance. These mirror peripheral tissues through promiscuous expression diverse set tissue-restricted self-antigens. The genes and signaling pathways that regulate development medullary are not fully understood. Here we show mice deficient NF-κB2, member NF-κB family, display marked reduction number mature express CD80...
Normal development of the immune system requires regulated processing NF-kappaB2 p100 to p52, which activates signaling. Constitutive production p52 has been suggested as a major mechanism underlying lymphomagenesis induced by mutations, occur recurrently in variety human lymphoid malignancies. To test hypothesis, we generated transgenic mice with targeted expression lymphocytes. In contrast their counterparts expressing tumor-derived mutant p80HT, develop predominantly B cell tumors, are...
Tomoharu Yasuda1, Tristan Wirtz1, Baochun Zhang2, Thomas Wunderlich3, Marc Schmidt-Supprian4, Sommermann1 and Klaus Rajewsky1 1Immune Regulation Cancer, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany 2Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 3Max Planck Institute Neurological Research, 50931 Cologne, 4Max Biochemistry, 82152 Martinsried, Correspondence: klaus.rajewsky{at}mdc-berlin.de tomoharu.yasuda{at}mdc-berlin.de
Abstract Exposure to ultraviolet ( UV ) light causes increased matrix metalloproteinase MMP activity and decreased collagen synthesis, leading skin photoaging. Salvianolic acid B SAB ), a polyphenol, was extracted purified from salvia miltiorrhiza . We assessed effects of on UVB ‐induced photoaging investigated its molecular mechanism action in ‐irradiated normal human dermal fibroblasts. Our results show that significantly inhibited the expression metalloproteinases‐1 ‐1) interleukin‐6 IL...
Abstract Extracellular signal‐regulated kinase (ERK) plays a central role in regulating cell growth, differentiation, and apoptosis. We previously found that 2‐(2‐mercaptoethanol)‐3‐methyl‐1,4‐napthoquinone or Compound 5 (Cpd 5), is Cdc25A protein phosphatase inhibitor causes prolonged, strong ERK phosphorylation which triggered by epidermal growth factor receptor (EGFR) activation. now report Cpd can directly cause inhibiting activity independently of the EGFR pathway. physically interacted...