A5047448639- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- interferon and immune responses
- RNA regulation and disease
- Pediatric health and respiratory diseases
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Lymphoma Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Calpain Protease Function and Regulation
- Diabetes and associated disorders
- Viral-associated cancers and disorders
- Cancer Mechanisms and Therapy
- T-cell and Retrovirus Studies
- Psoriasis: Treatment and Pathogenesis
- Veterinary medicine and infectious diseases
- Asthma and respiratory diseases
Universität Innsbruck
2019-2023
Max Delbrück Center
2013-2022
Harvard University
2006-2019
Boston Children's Hospital
2010-2019
Centre National de la Recherche Scientifique
2003
La Jolla Institute for Immunology
2003
Tumor necrosis factor-α (TNF-α) and lymphotoxin-β receptor (LTβR) signaling both play important roles in inflammatory immune responses through activation of NF-κB. Using various deficient mouse embryonic fibroblast cells, we have compared the pathways leading to NF-κB induction response TNF-α LTβR activation. We demonstrate that ligation induces not only RelA/p50 dimers but also RelB/p50 dimers, whereas dimers. LTβR-induced binding requires processing p100 is mediated by IKKα independent...
BAFF-R-dependent activation of the alternative NF-kappaB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression NIK and deletion TRAF3 gene are implicated human multiple myeloma. We show that mouse lymphocytes amplifies peripheral numbers a manner, whereas uncoupling from TRAF3-mediated control causes maximal p100 processing dramatic hyperplasia BAFF-R-independent cells. controls signaling by increasing protein levels its negative regulator...
Th17 cells are a proinflammatory subset of effector T that have been implicated in the pathogenesis asthma. Their production cytokine IL-17 is known to induce local recruitment neutrophils, but direct impact on lung epithelium poorly understood. In this study, we describe novel mouse model spontaneous IL-17-driven inflammation exhibits many similarities asthma humans. We found STAT3 hyperactivity lymphocytes causes an expansion cells, which home preferentially lungs. secretion then leads...
Upon activation by antigen, B cells form germinal centres where they clonally expand and introduce affinity‐enhancing mutations into their B‐cell receptor genes. Somatic mutagenesis class switch recombination (CSR) in centre are initiated the activation‐induced cytidine deaminase ( AID ). exit, differentiate antibody‐secreting plasma cells. Germinal maintenance terminal fate choice require transcriptional reprogramming that associates with a substantial reconfiguration of DNA methylation...
Significance Clonal expansion of antigen-specific B cells during an immune response is necessary for effective antibody production. must integrate signals from their clonally restricted B-cell antigen receptor (BCR) and nonclonal coreceptors that provide contextual cues to the nature antigen. How this accomplished unclear. We found require expression BCR mitogenic responses triggered by recognize innate or T-cell-derived signals. The signaling pathway used license coreceptor-induced...
Significance TNFα induces chemotaxis of inflammatory cells and fibroblasts, but little is known about the signaling mechanisms controlling this action. It generally accepted that avian reticuloendotheliosis viral oncogene (v-rel) related B (RelB) NF-κB subunit not activated downstream TNF receptors in fibroblasts. Here, we revealed an activating molecular mechanism leading to RelB transcriptional activation critical for control TNFα-induced fibroblast migration. We show IκB kinase (IKK)...
Significance Mature B cells are long-lived responsible for the Ab production in immune system. Canonical NF-κB signaling, one of two discrete pathways activating transcription factors family, participates generation a normal mature B-cell compartment. However, role these signals specifically is still imperfectly defined. Notably, their persistence follicular cells, main subset, controversial. Here, we show that canonical signaling does not contribute to immediate (short-term) survival...
Knockout of the ubiquitously expressed miRNA-17∼92 cluster in mice produces a lethal developmental lung defect, skeletal abnormalities, and blocked B lymphopoiesis. A shared target miR-17∼92 miRNAs is pro-apoptotic protein BIM, central to life-death decisions mammalian cells. To clarify contribution miR-17∼92:Bim interactions complex knockout phenotype, we used system conditional mutagenesis nine Bim 3′ UTR seed matches. Blocking early development phenocopied phenotype ablation generated...
B cells are key mediators of humoral immunity. Mature fall into various sub-classes that can be separated by their ontogeny, expression cell surface markers, anatomical location, and function. B1 subsets play important roles in natural immunity constitute the majority newborns. In adult, predominate pleural peritoneal cavities, while mature B2 follicular subset makes up major fraction lymphoid tissue, although antibody-secreting also present at these sites. main producers IgM but contribute...
Fogli, L. K., M. S. Sundrud, Goel, Bajwa, K. Jensen, E. Derudder, A. Sun, Coffre, C. Uyttenhove, J. Van Snick, Schmidt-Supprian, Rao, G. Grunig, Durbin, Casola, Rajewsky, and B. Koralov. 2013. T cell–derived IL-17 mediates epithelial changes in the airway drives
B lymphocyte development proceeds through a well-ordered sequence of steps, leading to the formation sizeable mature population recognizing diversity antigens. These latter cells are ultimately responsible for production antibodies upon immune challenges. The detection threats organism is facilitated by ability naïve follicular cells, main subset in mice, circulate between lymphoid tissues search their cognate miRNA-mediated fine-tuning mRNA stability and translation participates optimal...