A5084429684- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Diabetic Foot Ulcer Assessment and Management
- Research on Leishmaniasis Studies
- Eicosanoids and Hypertension Pharmacology
- Reproductive System and Pregnancy
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Toxoplasma gondii Research Studies
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Complement system in diseases
- Protein Tyrosine Phosphatases
- Inflammasome and immune disorders
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Pediatric health and respiratory diseases
- Toxin Mechanisms and Immunotoxins
- Probiotics and Fermented Foods
Université Toulouse III - Paul Sabatier
2013-2024
Inserm
2007-2024
Université de Toulouse
2014-2024
Centre National de la Recherche Scientifique
2009-2024
École Nationale Vétérinaire de Toulouse
2024
Établissement Français du Sang
2024
RESTORE
2023
Institut de Recherche pour le Développement
2012-2022
Pharmacochimie et Pharmacologie pour le Développement
2011-2022
Université de Montréal
2017
Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, loss dectin-1 on myeloid cells prevents intestinal inflammation, while lack mannose receptor (MR) exacerbates it. A marked increase in expression dextran sulfate sodium (DSS)-exposed MR-deficient mice supports critical contribution colitis outcome. Dectin-1 crucial for...
The class B scavenger receptor CD36 is a component of the pattern recognition receptors on monocytes that recognizes variety molecules. expression in depends exposure to soluble mediators. We demonstrate here induced human following IL-13, Th2 cytokine, via peroxisome proliferator-activated (PPAR)gamma pathway. Induction protein was paralleled by an increase mRNA. PPARgamma pathway demonstrated using transfection plasmid into murine macrophage cell line RAW264.7, expressing very low levels...
Liver receptor homologue-1 (LRH-1) is a nuclear involved in the repression of inflammatory processes hepatointestinal tract. Here we report that LRH-1 expressed macrophages and induced by Th2 cytokine IL-13 via mechanism involving STAT6. We show loss-of-function impedes IL-13-induced macrophage polarization due to impaired generation 15-HETE PPARγ ligands. The incapacity generate metabolites at least partially caused compromised regulation CYP1A1 CYP1B1. Mice with LRH-1-deficient are,...
Background Besides the interest of an early detection ovarian cancer, there is urgent need for new predictive and prognostic biomarkers tumor development cancer treatment. In healthy patients, circulating blood monocytes are typically subdivided into classical (85%), intermediate (5%) non-classical (10%) populations. Although these monocyte subsets have been suggested as in several diseases, few studies investigate their potential a signature immune status,tumor growth treatment adaptation....
Particular interest is now given to the potential of dietary supplements as alternative non-pharmacological approaches in intestinal inflammation handling. In this aim, study evaluates efficiency fish collagen peptides, Naticol®Gut, on colonic inflammation.Wild type and Mannose receptor-deficient myeloid lineage C57BL/6 mice were administered with Dextran Sodium Sulfate (DSS), DSS, Naticol®Gut or only water for 4 8 days. Inflammatory status was evaluated by establishing macroscopic...
Patients with diabetes present a persistent inflammatory process, leading to impaired wound healing. Since nonhealing diabetic management shows limited results, the introduction of advanced therapies targeting and correcting status macrophages in chronic wounds could be an effective therapeutic strategy stop sustained inflammation return healing state. In excisional skin injury diet-induced murine model, we demonstrate that topical administration low-dose aspirin (36 μg/wound/day) improves...
Background Ovarian adenocarcinoma (OVAD) frequently metastasizes to the peritoneal cavity and manifests by formation of ascites, which constitutes a tumor-promoting microenvironment. In cavity, two developmentally, phenotypically functionally distinct macrophage subsets, immunocompetent large macrophages (LPM) immunosuppressive small (SPM), coexist. Because peroxisome proliferator-activated receptor γ (PPARγ) is critical factor participating in differentiation cooperates with CCAAT/enhancer...
Abstract In chronic inflammatory diseases, such as rheumatoid arthritis, inflammation acts an independent cardiovascular risk factor and the use of anti-inflammatory drugs, anti-tumor necrosis alpha (anti-TNFα), may decrease this risk. The phagocytosis oxidized low density lipoproteins (LDLs) accumulated in subendothelium by mononuclear cells influences atherosclerosis depends on CD36 expression. We investigated role TNFα adalimumab, a human anti-TNFα monoclonal antibody widely used...
Abstract We recently demonstrated that in vitro peroxisome proliferator-activated receptor-γ (PPARγ) activation of mouse peritoneal macrophages by IL-13 or PPARγ ligands promotes uptake and killing Candida albicans through mannose receptor overexpression. In this study, we demonstrate i.p. treatment immunocompetent immunodeficient (RAG-2−/−) mice with natural synthetic PPARγ-specific decreases C. colonization the gastrointestinal (GI) tract 8 days following oral infection yeast. also showed...
Monocytes are plastic heterogeneous immune cells involved in host-parasite interactions critical for malaria pathogenesis. Human monocytes have been subdivided into three populations based on surface expression of CD14 and CD16. We hypothesised that proportions phenotypes circulating monocyte subsets can be markers severity or fatality children with malaria. To address this question, we compared sampled uncomplicated malaria, severe malarial anaemia, cerebral Flow cytometry was used to...
Macrophage-mediated cytotoxicity is controlled by surface receptor expression and activation. Despite the numerous studies documenting role of macrophage C-type lectin receptors (CLR) in pathogen elimination, little known about their contribution to antitumor responses. Here, we report that IL13 inhibits T-cell lymphoma ovarian adenocarcinoma development tumor-bearing mice through conversion tumor-supporting macrophages cytotoxic effectors, characterized a CLR signature composed dectin-1...
Significance TNFα induces chemotaxis of inflammatory cells and fibroblasts, but little is known about the signaling mechanisms controlling this action. It generally accepted that avian reticuloendotheliosis viral oncogene (v-rel) related B (RelB) NF-κB subunit not activated downstream TNF receptors in fibroblasts. Here, we revealed an activating molecular mechanism leading to RelB transcriptional activation critical for control TNFα-induced fibroblast migration. We show IκB kinase (IKK)...
Candida albicans is an opportunistic pathogen that causes mucosal gastrointestinal (GI) candidiasis tightly associated with gut inflammatory status. The emergence of drug resistance, the side effects currently available antifungals and high frequency recurrent indicate new improved therapeutics are needed. Probiotics have been suggested as a useful alternative for management candidiasis. We demonstrated oral administration Lactobacillus gasseri LA806 alone or combined helveticus LA401 in...
The adverse effects and emergence of resistance currently available antifungals the high recurrence candidiasis prompt need for alternative complementary strategies. We demonstrated that oral administration hydroethanolic extracts licorice root (LRE) walnut leaf (WLE) separately or in combination significantly reduced colonization gastrointestinal (GI) tract by C. albicans , highlighting a robust antifungal activity these plant extracts.
Despite the growing knowledge with regard to immunomodulatory properties of host defense peptides, their impact on macrophage differentiation and its associated microbicidal functions is still poorly understood. Here, we demonstrated that P17, a new cationic antimicrobial peptide from ant venom, induces an alternative phenotype human monocyte-derived macrophages (h-MDMs). This characterized by C-type lectin receptors (CLRs) signature composed mannose receptor (MR) Dectin-1 expression....
Within adipose tissue (AT), different macrophage subsets have been described, which played pivotal and specific roles in upholding homeostasis under both physiological pathological conditions. Nonetheless, studying resident macrophages