A5100711063- RNA modifications and cancer
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Nutritional Studies and Diet
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Use and Resistance
- Dementia and Cognitive Impairment Research
- Esophageal Cancer Research and Treatment
- Electrocatalysts for Energy Conversion
- Gut microbiota and health
- Patient Satisfaction in Healthcare
- Molecular Biology Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Anesthesia and Sedative Agents
Anhui Medical University
2019-2025
Wuhan University of Science and Technology
2022-2025
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Hebei Medical University
2023-2024
Union Hospital
2020-2024
Huazhong University of Science and Technology
2008-2024
Fujian University of Traditional Chinese Medicine
2022-2024
First Affiliated Hospital of Soochow University
2024
Shanghai Jiao Tong University
2023-2024
Abstract Background Missing data is frequently an inevitable issue in cohort studies and it can adversely affect the study's findings. We assess effectiveness of eight utilized statistical machine learning (ML) imputation methods for dealing with missing predictive modelling study datasets. This evaluation based on real models cardiovascular disease (CVD) risk. Methods The from a real-world Xinjiang, China. It includes personal information, physical examination data, questionnaires,...
BackgroundCancer patients had been profoundly affected by the outbreak of COVID-19 especially after quarantine restrictions in China. We aimed to explore treatment changes and delays early breast cancer (EBC) during first quarter 2020.MethodsWe did this retrospective, multicentre, cohort study at 97 centres EBC who received regardless preoperative therapy, surgery or postoperative therapy 2020 were included.Findings8397 eligible with a median age 50 (IQR 43–56). 0·2% (15/8397) confirmed as...
Abstract Background The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) exemestane (EXE) in treatment estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BOLERO-5 investigated this a Chinese population (NCT03312738). Methods is randomized, double-blind, multicenter, placebo controlled, phase II comparing EVE (10 mg/day) or (PBO) with EXE (25 mg/day). primary endpoint was progression-free survival (PFS) per investigator assessment....
Abstract Alzheimer's disease (AD) is a type of dementia characterized by decline in brain function, which leads to the inability perform activities independently. Many researchers recognize abnormalities related beta‐amyloid as main cause (i.e., hypothesis), but aging, genetics, coronary heart disease, environmental factors, gender, and other risk factors may also contribute AD development. Three drugs with different mechanisms are available for treatment: cholinesterase inhibitors, N‐methyl...
Objective During the COVID-19 pandemic, many parents faced heightened stress, anxiety and depression due to local global mitigation measures lockdowns. Design This is a cross-sectional study. Setting study used stratified whole-cluster sampling randomly select three elementary schools within Ezhou City. Participants An online survey was administered of students in one or two classes grades 1–6, respectively, each school. Among them, males account for 30.4% females 69.6%. The inclusion...
Objective The aim of this study was to investigate inequalities in primary healthcare visits by using the Gini coefficients (GPVs) as derived from large-scale and region-wide electronic records explore estimation utility GPV. Design used a cross-sectional design. It first extracted random sample 7.09 million care 1 October 2019 31 December 2021. Then it developed logarithmic models GPVs different months performed descriptive generalised linear mixed-effects regression analyses for all-cause...
Abstract Objective This study aimed to explore and compare the role of cumulative exposure four blood pressure (BP) markers [systolic (SBP), diastolic (DBP), mean arterial (MAP), pulse (PP)] in predicting cardiovascular disease (CVD) risk Uyghur population. Methods We recruited 3,553 Uyghurs from Tumxuk City, conducted measurements on them at least three times, with a minimum interval two years between consecutive measurements. Cumulative BP was defined as sum product average examinations...
Norovirus (NoV) is an important cause of viral acute gastroenteritis (AGE). To gain insights into the epidemiological characteristics and genetic diversity NoV among children in Hubei, 1216 stool samples from (≤ 5 years) obtained under AGE surveillance January 2017 to December 2019 were analyzed. The results showed that was responsible for 14.64% cases, with highest detection rate aged 7-12 months (19.76%). Statistically significant differences found between male female infection rates (χ2...
Objective: The regional inequality of emergency medicine beds distribution has a great impact on population health as well the accessibility services. This study aimed to explore bed and its influencing factors. Methods: Gini coefficient resource agglomeration were used analyze by area from 2012 2021 in China. Grey correlation models factors distribution. Results: From 2021, coefficients geographic China showed worsening trend, rising 0.6229 0.6636. average HRAD index was 3.43 east 0.44...
Objective: Changes in the number of various tumor-infiltrating lymphocytes (TILs) and degrees vascular normalization breast cancer (BC) patients after neoadjuvant chemotherapy (NAC) were analyzed to screen key factors that can predict prognosis. Methods: HE-stained sections used assess degree TILs infiltration; immunohistochemically stained infiltration CD8+, CD4+, FOXP3+ Tregs expression PD-L1; immunofluorescence-stained microvessel density (MVD) pericyte coverage index (MPI). The them...
The suboccipital cavernous sinus (SCS) and the myodural bridge complex (MDBC) are both located in region. SCS is regarded as a route for venous intracranial outflow often encountered during surgery. MDBC consists of muscles, nuchal ligament, could be power source cerebrospinal fluid circulation. Intracranial pressure depends on blood volume fluid. Since have similar anatomical locations functions, aim present study was to reveal relationships between them detailed characteristics SCS....
Knee osteoarthritis (KOA) is an increasingly prevalent heterogeneous disease characterized by cartilage erosion and inflammation. As the main chemical constituent of Angelicae Pubescentis Radix (APR), anti-inflammatory herbal medicine, potential biological effects underlying mechanism osthole on chondrocytes KOA progression remain elusive. In this study, effect were investigated in vitro vivo. We found that inhibited IL-1β-induced apoptosis matrix degeneration activating autophagy rat...