A5086647275- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Neural dynamics and brain function
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Genetic Syndromes and Imprinting
- MicroRNA in disease regulation
- Genetic and Kidney Cyst Diseases
- Glaucoma and retinal disorders
- Ferroptosis and cancer prognosis
- Inflammatory mediators and NSAID effects
- Hedgehog Signaling Pathway Studies
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Molecular Biology Techniques and Applications
- NF-κB Signaling Pathways
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
First People's Hospital of Yunnan Province
2013-2023
Kunming University of Science and Technology
2014-2020
Third People's Hospital of Yunnan Province
2019
Southern Medical University
2017
Nanfang Hospital
2017
Taishan University
2016
Second Affiliated Hospital of Kunming Medical College
2009-2012
Kunming Medical University
2009-2012
Eye & ENT Hospital of Fudan University
2006-2008
Institute of Biophysics
2000-2008
Introduction: Curcuma wenyujin is a plant which belongs to the family of Zingiberaceae , found in South Asia and China. C. major constituent Chinese traditional medicine used treat liver diseases, blood clots, also prescribed as painkiller. possesses antioxidant, antiproliferative, antitumorogenic properties, many researchers have proved efficacy against various types cancer. The drawback this historical drug it’s low bioavailability. Methods: This study synthesized gold nanoparticles using...
Abstract Background Small cell lung cancer (SCLC) is one of the deadliest malignancies and accounts for nearly 15% cancers. Previous study had revealed genomic characterization SCLC in Western patients. However, little known about that Chinese Methods Formalin‐fixed paraffin‐embedded tumor tissues matched blood samples from 122 patients were collected next generation sequencing to detect 450 cancer‐related genes. All pathological diagnoses confirmed by independent pathologists. Results The...
Gastric cancer is the fourth most common malignant disease and second leading cause of cancer‑associated mortalities worldwide. Previous studies revealed aberrantly expressed microRNAs (miRNAs) in various types human cancer; these miRNAs play important roles tumourigenesis tumour development. present a considerable potential for novel therapeutic approaches treating cancer. Therefore, investigation involved gastric progression provides an opportunity to improve prognosis patients with...
Lung squamous cell carcinoma (LUSC) is the second most common histological subtype of lung cancer (LC), and prognoses LUSC patients are so far still very poor. The present study aimed at integrating lncRNA, miRNA mRNA expression data to identify lncRNA signature in competitive endogenous RNA (ceRNA) network as a potentially prognostic biomarker for patients.Gene clinical characteristics were retrieved from Cancer Genome Atlas (TCGA) database, integratedly analyzed using bioinformatics...
Background: miRNAs were found to play crucial roles in regulating cellular behaviors. The aim of this study was investigate the biological function miRNA-99b-5p (miR-99b-5p) non-small cell lung cancer (NSCLC). Materials and methods: miR-99b-5p expression level NSCLC lines detected by quantitative real-time PCR (qRT-PCR). Cell proliferation, migration invasion examined counting kit-8 (CCK-8) assay, wound-healing assay Transwell respectively. Dual-luciferase activity reporter Western blot...
Objectives: Tuberculous peritonitis (TBP) mimics peritoneal carcinomatosis (PC). We aimed to investigate the discriminative use of PET/CT findings in parietal peritoneum. Materials and Methods: Parietal from 76 patients with TBP (n = 25) PC 51) were retrospectively reviewed. The lesion locations noted as right subdiaphragmatic, left paracolic gutters, pelvic regions. distribution characteristic consisted a dominant and/or subdiaphragmatic region (susceptible area for implantation, SAPI)...
Abstract Aberrant microRNA expression is involved in the regulation of various cellular processes, such as proliferation and metastasis multiple diseases including cancers. MicroRNA‐30e‐5p (miR‐30e) was previously reported an oncogenic or tumour suppressing miRNA some malignancies, but its function lung adenocarcinoma (LAC) remains largely undefined. In this study, we found that miR‐30e increased LAC tissues cell lines, associated with size represented independent prognostic factor for...
We investigated the relationship between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) in children adolescents.We carried out a retrospective study of thyroidectomies performed from 2004 to 2017 at The First People's Hospital Tumor Yunnan Province (Kunming, China). occurrence features PTC benign disease (BTD) adolescents (age ≤ 20 years) were compared.We evaluated 258 consecutive thyroidectomies. Among with PTC, 23 cases histopathologically confirmed as HT. Mean tumor...
Cytoplasmic polyadenylation element binding protein 4 (CPEB4) could be an important regulator in variety of cancers. However, the biological function and underlying molecular mechanism CPEB4 non-small cell lung cancer (NSCLC) remains unknown. In this study, we investigated metastasis role NSCLC cells, knocked down using siRNA. Transwell migration assay invasion on Matrigel were presented, was also determined by scratch-healing assay. ROS generation fluorescence probe DCFH2-DA. The expression...
13‑Chlorine‑3,15‑dioxy‑gibberellic acid methyl ester (GA‑13315), a gibberellin derivative, possesses strong anti‑tumor activity in vitro and vivo. The present study aimed to investigate the underlying mechanisms of GA‑13315‑induced apoptosis human non‑small cell lung cancer lines. Lung cells were treated with different doses GA‑13315 (4, 8, 16 32 ng/µl) for 48 h, CCK8 assay was performed measure viability. Alteration gene expression identified using RNA‑sequencing (RNA‑Seq). Quantitative...
This study investigated clinical and pathological characteristics risk factors in papillary thyroid carcinoma (PTC) patients' native to Yunnan plateau southwestern China.Clinical data from 1,198 patients diagnosed with PTC (n=578) control subjects (n=620) benign disease (ie, nodule disease, diseases [BTD]) province were analyzed retrospectively.The mean patient age was lower for than BTD. Positive ratios of peroxidase antibody, thyroglobulin antibody (TGAb), thyrotrophin receptor (TRAb)...
Xuanwei County in Southwest China shows the highest incidence and mortality rate of lung cancer China. Although studies have reported distinct clinical characteristics patients from Xuanwei, molecular features these with non-small cell (NSCLC) remain unclear. Here, we comprehensively characterised such cases using next-generation sequencing (NGS). Formalin-fixed, paraffin-embedded tumour samples 146 NSCLC were collected for an NGS-based target panel assay; their compared those reference...