A5101706485- Adipose Tissue and Metabolism
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Osteoarthritis Treatment and Mechanisms
- Bacterial Identification and Susceptibility Testing
- Head and Neck Cancer Studies
- Cancer Risks and Factors
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Pituitary Gland Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HER2/EGFR in Cancer Research
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Breastfeeding Practices and Influences
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Bone fractures and treatments
- Hip and Femur Fractures
- Respiratory viral infections research
- Orthopaedic implants and arthroplasty
- Peroxisome Proliferator-Activated Receptors
- Stress Responses and Cortisol
- Gastrointestinal Tumor Research and Treatment
Sun Yat-sen University
2021-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2021-2024
Nanchang University
2012-2022
First Affiliated Hospital of Nanchang University
2012-2022
Chinese National Human Genome Center
2014
Chinese National Human Genome Center at Shanghai
2014
Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of osteoarthritis (OA).Nevertheless, precise molecular mechanisms underlying chondrocyte remain poorly understood.To address this knowledge gap, we conducted an investigation into involvement Sirtuin 4 (Sirt4) senescence.Our experimental findings revealed downregulation Sirt4 expression TBHP-induced senescent chondrocytes vitro, well mouse OA cartilage.Additionally, observed that knockdown...
Corticotrophin‐releasing hormone (CRH) has been demonstrated to participate in various diseases. Our previous study showed that its receptor CRHR1 mediated the development of colitis‐associated cancer mouse model. However, detailed mechanisms remain unclear. In this study, we explored oncogenetic role CRH/CRHR1 signaling colon cells. Cell proliferation and colony formation assays revealed CRH contributed cell proliferation. Moreover, tube assay CRH‐treated supernatant significantly promoted...
Abstract Background The optimal treatment of Pauwels type III femoral neck fracture (FNF) in young patients remains a worldwide challenge orthopedic surgery. Methods Finite element models four internal fixations were developed to treat FNF: a: the traditional inverted triangular parallel cannulated screw (PCS) model, b: F-technique c: modified model using fully threaded instead partially distally, d: dynamic hip coupled with derotational (DHS + DS) model. Under same conditions, finite...
Highly pathogenic avian influenza (HPAI) H5N1 virus infection is still a potential threat to public health worldwide. While vaccines and antiviral drugs are currently under development, neutralizing antibodies could offer an alternative strategy prevent treat infection. In the present study, we had developed humanized antibody against viruses from mouse-derived hybridoma in order minimize its immunogenicity for clinical application. The hH5M9 was generated by transferring mouse...
Pancreas-preserving duodenectomy for treatment of a duodenal papillary tumor: A case report
Objective To detect the expression of P21 in normal breast tissues, ductal carcinoma situ (DCIS) and invasive cancer, respectively, to explore its relationship with clinical characteristics, pathological markers, recurrence, metastasis, prognosis cancer. Methods Immunohistochemical staining (SP) was used 22 cases 32 DCIS, 40 cancer. The correlation their expressions relevant data statistically analyzed. Results Expression tissues were gradually decreased. Expression cancer had...
Objective To investigate the relationship between expression of ER,PR,HER-2,Ki-67 and effective rate neoadjuvant chemotherapy (NAC) to study influence NAC on ER,PR,HER-2 Ki-67 in breast cancer.Methods 41 patients cancer were performed 2 6 cycles CAF chemotherapy.The was detected by SP immunohistochemical method before after NAC.Results The 73.17％ (30/41).The positive negative efficiency 67.86％ (19/28) vs 84.62％ ( 11/13 ) for ER,64.29％ (9/14) 77.78％ (21/27 HER-2,70.00％ (14/20) 76.19％ 16/21...