A5058280163- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Hip disorders and treatments
- Bone fractures and treatments
- Nanoparticle-Based Drug Delivery
- Shoulder Injury and Treatment
- Heterotopic Ossification and Related Conditions
- Elbow and Forearm Trauma Treatment
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Inflammatory mediators and NSAID effects
- Total Knee Arthroplasty Outcomes
- Hydrogels: synthesis, properties, applications
- Periodontal Regeneration and Treatments
- RNA modifications and cancer
- MXene and MAX Phase Materials
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Medical and Biological Sciences
- Extracellular vesicles in disease
First Hospital of Jilin University
2012-2024
Jilin University
2012-2024
Ankang City Central Hospital
2022
First Bethune Hospital of Jilin University
2013
First Affiliated Hospital of Nanchang University
2012
Nanchang University
2012
Recent studies suggest important roles for long non-coding RNAs as essential regulators of myogenic differentiation. Here, we report that lncRNA Irm is upregulated during myogenesis. Functional analyses show the overexpression enhances differentiation, whereas inhibition has completely opposite effects in vitro. Notably, blocks damage-induced muscle regeneration vivo. Mechanistically, regulates expression genes by directly binding to MEF2D, which turn promotes assembly MyoD/MEF2D on...
Surface coating is the simplest surface modification. However, bioactive molecules can not spread well on commonly used polylactone-type skeletons; thus, coatings of biomolecules are typically unstable due to weak interaction between polymer and molecules. In this study, a special type poly(lactide-co-glycolide) (PLGA)-based scaffold with loosened skeleton was fabricated by phase separation, which allowed gelatin more readily diffuse throughout structure. application, modified both internal...
Gastric cancer is one of the common malignant diseases. The poor treatment outcome mainly due to chemotherapeutic resistance. Therefore, it important determine molecular mechanism drug resistance in gastric cancer. To explore mechanisms cisplatin cells, several approaches were performed including MTT assay, real-time RT-PCR, western blot analysis, migration and invasion assays, wound healing transfection. We found that cisplatin-resistant (CR) cells acquired epithelial-mesenchymal transition...
Glibenclamide is a promising agent for treating brain oedema, but whether it improves clinical outcomes in patients with intracerebral haemorrhage (ICH) remains unclear. In this study, we aimed to explore the efficacy and safety of glibenclamide treatment acute ICH.The Advantage Treating Oedema after Intracerebral Haemorrhage (GATE-ICH) study was randomised controlled phase 2 trial conducted 26 hospitals northwest China, recruiting ganglia ICH no more than 72 h onset from Dec 12, 2018 Sept...
Bone marrow mesenchymal stem cells (BMSCs) are considered as multipotent cells, representing a multilineage potential to differentiate into mesodermal lineages of tissues, including cartilage, bone, fat, muscle and tendon. Tissue engineering in BMSCs has made great advances the regeneration cartilage bone defects. To uncover mechanisms differentiation process, molecular changes gene expression profiles during chondrogenic osteogenic need be evaluated with reliable, accurate, fast sensitive...
Osteosarcoma is a serious bone malignancy that threatens to human health, while the conventional chemotherapy exhibits ineffective and severe side effects. Here, multi-approach for primary metastatic tumors was developed by combining photothermal ablation-based in situ tumor vaccine with PD-1/PD-L1 blockade immunotherapy. Polyethyleimine modified golden nanorod (GNR-PEI) prepared conjugating of hyperbranched PEI GNR via SAu bonds. The positive charged GNR-PEI could complex cyclic dimeric...
Introduction: Polyetheretherketone (PEEK) material implants have been applied more and clinically recently. In order to increase the osteogenic activity of PEEK material, microstructure change surface construction functional microcoatings become a hot research topic. This study investigated ability surfaces modified by different methods carry Platelet-rich plasma (PRP) microstructures after carrying PRP in vivo / vitro . Methods: this study, were sulfuric acid, gaseous sulfur trioxide...
Osteosarcoma (OS) is the most common primary malignant bone tumor. In clinic, usual strategies for OS treatment include surgery, chemotherapy, and radiation. However, all of these therapies have complications that cannot be ignored. Therefore, search better treatments urgent. Black phosphorus (BP), a rising star 2D inorganic nanoparticles, has shown excellent results in therapy due to its outstanding photothermal, photodynamic, biodegradable biocompatible properties. This review aims present...
Saikosaponin a (SSa), one of the main active components Bupleurum falcatum, has been reported to have anti-inflammatory effect. In present study, we investigated effect SSa on IL-1β-stimulated human osteoarthritis chondrocytes. The cells were pretreated with 12 h before IL-1β treatment. production PGE2 and NO detected by ELISA Griess method. levels MMP1, MMP3, MMP13 measured qRT-PCR. expression NF-κB LXRα tested western blot analysis. results showed that inhibited IL-1β-induced in...
Bone-resorbing osteoclasts significantly contribute to osteoporosis, and understanding the mechanisms of osteoclastogenesis is crucial for developing new drugs treat diseases associated with bone loss. Here, we report that POLR2A upregulated during osteoclastogenesis. Functional analyses showed inhibition decreased osteoclastogenesis, whereas overexpression had completely opposite effects in vitro. Notably, osteoclast-specific deletion blocks resorption vivo. Furthermore, loss-of-function...
Bone xenografting is considered one of the most effective ways to address shortage bone autografts and allografts. Various methods have been employed minimize immune rejection issues associated with xenografts. However, side effects such on biomechanical properties remain unclear. As such, objective this study was compare influence different treatments porcine bones. Fresh pig ribs were cut into 1.5 × 0.5 0.4 cm specimens, which randomly divided four groups subjected modification regimes:...
To explore repairing results of VEGF165 gene modified adipose-derived stem cells for diabetic rats with bone defect.Seventy-eight male Wistar weighted 180 to 220 g were selected, 72 established animal models by streptozotocin inducement method, blood glucose level was more than 16.7 mmol/L. Experimental animals randomly divided into 5 groups, 6 in normal group and each 18 other groups. implanted defect; single defect named as group;vascular endothelial growth factor group; names cell...
Aim To explore the effects of tibial osteotomy varus angle combined with posterior slope (PTS) on stress polyethylene liner in total knee arthroplasty (TKA) by building finite element model (FEM). Methods Established FEM standard TKA 0° to 9° were established and divided into 10 groups. Next, each group was created FEMs PTS separately. Calculated Abaqus. Finally, relevancy between statistically analyzed using multiple regression analysis. Results As increased, area maximum gradually shifted...