A5076815349- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Neurosurgical Procedures and Complications
- Pediatric health and respiratory diseases
- Ginkgo biloba and Cashew Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Ubiquitin and proteasome pathways
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Traumatic Brain Injury and Neurovascular Disturbances
- Peptidase Inhibition and Analysis
- Voice and Speech Disorders
- Pneumonia and Respiratory Infections
- Sarcoma Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- Lipid metabolism and biosynthesis
- Exercise and Physiological Responses
- Inflammatory mediators and NSAID effects
Xian Yang Central Hospital
2022-2025
Yunnan University of Traditional Chinese Medicine
2020-2023
Imaging Center
2023
Yunnan University
2023
Xiangya Hospital Central South University
2021-2022
Central South University
2021-2022
Binzhou People's Hospital
2012-2020
Huangshan University
2010
Sun Yat-sen University
2005-2009
Abstract Objective To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation. Design Multicentre randomised controlled trial. Setting 31 hospitals China, 24 January 2023 to August 2023. Participants 208 (grade 2b50-3 on extended thrombolysis cerebral infarction scale) an V4 segment vertebral artery; proximal, middle, or distal basilar P1 artery: 104 were...
Abstract Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets to attenuate drug-induced apoptosis. However, little known about whether and how MUC1 contributes mitochondrial homeostasis in cancer cells. We identified novel role promoting mitophagy. Increased mitophagy coupled with the translocation mitochondria, where interacts induces degradation ATPase family AAA domain-containing 3A (ATAD3A),...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common global chronic disease. Jiuzhuan Huangjing Pills (JHP) have been used for the treatment of human over thousand years, but their efficacy and underlying mechanism(s) action against MAFLD are unknown. We investigated alleviating effects JHP on high-fat diet (HFD)-induced MAFLD.In vitro in vivo methods were to evaluate MAFLD. L02 adipocyte models induced by fat emulsion adipocytes treated with 24 h. rat HFD-feeding...
Jiuzhuan Huangjing Pills (JHP) composed of Polygonati Rhizoma (PR) and Angelicae Sinensis Radix (ASR) remedied mitochondria to cure metabolic dysfunction-associated fatty liver disease (MAFLD). However, a comparison the anti-MAFLD ability between JHP prescription PR ASR single-medicines in MAFLD has not been performed, action mechanisms substances remain unknown. Our results show that JHP, decreased serum lipid levels. The effects were stronger than those ASR. afforded protection...
Glibenclamide is a promising agent for treating brain oedema, but whether it improves clinical outcomes in patients with intracerebral haemorrhage (ICH) remains unclear. In this study, we aimed to explore the efficacy and safety of glibenclamide treatment acute ICH.The Advantage Treating Oedema after Intracerebral Haemorrhage (GATE-ICH) study was randomised controlled phase 2 trial conducted 26 hospitals northwest China, recruiting ganglia ICH no more than 72 h onset from Dec 12, 2018 Sept...
Long-term muscle fatigue is a major cause of injury. Drugs/nutrients from herbal medicines that prevent remain research focus. In China, prescription composed Polygonati Rhizoma and Notoginseng Radix et has been commonly used as herb food nutrient, providing protection against in the clinic. To date, mechanisms through which this prevented are unknown. Here, we identified effects on based energy oxidation regulation. Fatigue mouse models were produced weight-bearing exhaustive swimming. Mice...
This study aimed to explore whether 99mTc-radiolabeled fibroblast activation protein inhibitor (99mTc-HFAPi) imaging can detect early myocardial fibrosis in the hypertensive heart.In experimental model, spontaneously rats (SHRs) and age-matched Wistar Kyoto (WKYs) were randomly divided into three groups (8, 16, 28 weeks). The animals underwent 99mTc-HFAPi echocardiography. Autoradiography histological analyses performed left ventricle. mRNA expression level of (FAP) collagen I measured using...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic that currently lacks approved pharmacological treatment options. The mechanisms and active ingredients of Polygonum cuspidatum (PC) regulate the mitochondria to relieve MAFLD have not been assessed. Thus, this study was designed explore bioactive components PC extract in regulating alleviate high-fat diet-induced using mitochondrial pharmacology pharmacochemistry. Our results demonstrate protected ultrastructure...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a severe threat to human health.
Introduction: Brain edema after acute intracerebral hemorrhage (ICH) plays a critical role in the secondary injury of ICH and may heighten potential for poor outcome. This trial aims to explore efficacy small doses oral glibenclamide perihematomal (PHE) prognosis patients with ICH. Methods Analysis: The GATE-ICH is multicenter randomized, controlled, assessor-blinded trial. A total 220 adult primary 28 study centers China will be randomized group (glibenclamide plus guideline-recommended...
We investigated the prognostic significance of carcinoembryonic antigen (CEA) and vascular endothelial growth factor (VEGF) their associations with clinicopathological features in patients sigmoid colon carcinoma (SCC).We retrospectively reviewed SCC treated curative surgery from January 2001 to June 2010 at our hospital. Patients' general, clinical, histopathologic, serum biomarkers were analyzed. measured VEGF 176 sets tissues adjacent noncancerous tissue samples immunohistochemical...
Objective To observe Shenling-Baizhu granule combined with saccharomyces boulardii treatment for pediatric antibiotic associated diarrhea (AAD). Methods A total of 146 children AAD were randomly divided into the control group (n=73) and observation (n=73). The received boulardii, granule, a course 5 days. CD4 CD8 T lymphocytes detected by flow cytometry. stool frequency, frequency recovery time, clinic effects compared. Results The (3.0 ± 0.4 times/d vs. 3.6 times/d, t=2.624),...
Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, dysfunctional mitochondria misfolded proteins. Many human diseases, particularly neurodegenerative are related to disorders phagocytosis. Exploring regulatory mechanisms mitophagy is great significance for revealing molecular underlying diseases. Herein, we summarize major mitophagy, relationship with traditional Chinese medicine (TCM) mitophagy. These...
Objective To investigate the problem of diagnosis and treatment cough variant asthma (CVA) in china,and provide a basis for improving level CVA.Methods retrieve analyse CVA domestic literatures published past two years.Results In 216 selected literatures,there are 213 testing bronchial provocation or dilation,in 119 documents related to treatment,there 86 with regimen using glucocorticoids (including intravenous,oral,and inhalation),in all literatures,the application dosage,route...
Objective To investigate the clinical efficacy of treatment long-term non-invasive positive pressure ventilation (NIPPV) combined with inhaling corticosteroids in patients stable chronic o0bstructive pulmonary disease(COPD) complicated respiratory failure,and to impact longterm NIPPV on serum levels matrix metalloproteinase-9 (MMP-9).Methods Eighty outpatients severe COPD failure divided them equally into two groups (the experimental and control groups).The were given oxygen...
Objective To study the preventive and therapeutic effects of blood pressure control on hematoma expansion neurological function in patients with ultra-early basal ganglia intracerebral hemorrhage.Methods From November 2009 to 2011,120 hemorrhage from our Hospital were enrolled randomly divided into intensive reduction group general equal numbers (n =60).The antihypertensive agent used intravenously reduce systolic by 130-140 mm Hg within l hour after treatment group; was 160-180 Hg.The both...
Objective To observe whether Lingustrazine Phosphate for injection has vascular stimulation,haemocytolysis and anaphylaxis.Methods The safety of were observed through stimulation test ear vein in rabbit,hemolytic using rabbit erythrocyte vitro,active systemic anaphylaxis(ASA)in guinea pig passive cutaneous anaphylaxis(PCA)in rats.Results results showed that the Injection played no irritative effects,and haemocytolysis agglutination reaction both negatives.The active anaphylaxis negative...