A5031640559- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- RNA modifications and cancer
Shanghai Jiao Tong University
2022-2025
Abstract Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets to attenuate drug-induced apoptosis. However, little known about whether and how MUC1 contributes mitochondrial homeostasis in cancer cells. We identified novel role promoting mitophagy. Increased mitophagy coupled with the translocation mitochondria, where interacts induces degradation ATPase family AAA domain-containing 3A (ATAD3A),...
Mitophagy plays a critical role in maintaining mitochondrial quality and cellular homeostasis. But the specific contribution of mitophagy-related E3 ubiquitin ligases to prognosis remains largely unexplored. In this study, we identified novel prognostic signature using least absolute shrinkage selector operator (LASSO) multivariate Cox regression analyses breast cancer. Based on median risk scores, patients were divided into high-risk low-risk groups. Functional enrichment conducted explore...
Mitophagy plays a critical role in maintaining mitochondrial quality and cellular homeostasis. But the specific contribution of mitophagy-related E3 ubiquitin ligases to prognoses remains largely unexplored. In this study, we identified novel ligase prognostic signature using least absolute shrinkage selector operator (LASSO) multivariate Cox regression analyses breast cancer. Based on median risk scores, patients were divided into high-risk low-risk groups. Functional enrichment conducted...