A5100435700- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- NF-κB Signaling Pathways
- Immune cells in cancer
- Pain Mechanisms and Treatments
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Adenosine and Purinergic Signaling
- Cancer-related gene regulation
- Antimicrobial Resistance in Staphylococcus
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Biochemical Analysis and Sensing Techniques
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Asthma and respiratory diseases
- Biochemical and Structural Characterization
- Hypothalamic control of reproductive hormones
Yunnan Agricultural University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2016-2024
Xiamen University
2010-2024
First Affiliated Hospital of Nanchang University
2019-2024
Ningbo University
2023-2024
Johns Hopkins University
2023
Lieber Institute for Brain Development
2023
First Affiliated Hospital of Xiamen University
2010-2023
Johns Hopkins Medicine
2023
OLIG2 is a transcription factor that activates the expression of myelin-associated genes in oligodendrocyte-lineage cells. However, mechanisms myelin gene inactivation are unclear. Here, we uncover non-canonical function transcriptional repression to modulate myelinogenesis by functionally interacting with tri-methyltransferase SETDB1. Immunoprecipitation and chromatin-immunoprecipitation assays show recruits SETDB1 for H3K9me3 modification on Sox11 gene, which leads inhibition during...
The G9a/GLP complex mediates mono- and dimethylation of Lys9 histone H3 at specific gene loci, which is associated with transcriptional repression. However, the molecular mechanism by targeted to loci for H3K9 methylation unclear. In this study, unbiased protein affinity purification, we found ZNF644 WIZ as two core subunits in complex. interact transcription activation domain G9a GLP, respectively. Moreover, both contain multiple zinc finger motifs that recognize consensus DNA sequences....
Diabetic neuropathic pain (DNP), one of the early symptoms diabetic neuropathy, relates to metabolic disorders induced by high blood glucose, neurotrophic vascular ischemia and hypoxia, autoimmune factors. This study was aimed at exploring effects long noncoding RNA (lncRNA) BC168687 siRNA on DNP mediated P2X7 receptor SGCs in DRG rats. The mechanical withdrawal threshold (MWT) thermal latency (TWL) rats, expression levels mRNA protein DRG, nitric oxide (NO) serum were, respectively,...
Chronic infection of hepatitis B virus (HBV) is closely associated with the development human hepatocellular carcinoma (HCC). HBV X protein (HBx) plays a key role in progression HCC. We recently found that amplified breast cancer 1 (AIB1) overexpressed 68% HCC specimens and promotes by enhancing cell proliferation invasiveness. Given both HBx AIB1 play important oncogenic roles HCC, we aimed to determine whether they could cooperatively promote development. Herein, show HBx-positive tissues...
Pien Tze Huang (PZH) is a valuable traditional Chinese medicine, which has variety of biological activities such as clearing heat-toxin, resolving blood stasis, detoxifying, relieving pain, and anti-inflammation. PZH partial role in suppressing the progression CRC, while underlying mechanism pending mystery; especially whether mediates immune escape CRC remains unclear. Our study reported that suppressed proliferative activity by inhibiting Wnt/β-catenin signaling to down-regulate expression...
Cancer stem-like cells (CSCs) contribute to the high rate of tumor heterogeneity, metastasis, therapeutic resistance, and recurrence. Histone lysine demethylase 4D (KDM4D or JMJD2D) is highly expressed in colon liver tumors, where it promotes cancer progression; however, role JMJD2D CSCs remains unclear. Here, we show that expression was increased (LCSCs); downregulation inhibited self-renewal LCSCs vitro vivo lung metastasis by reducing survival early seeding circulating LCSCs....
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which frequently mutated in breast and ovarian cancers. BRCA1 plays key role the homologous recombination directed DNA repair, allowing its deficiency to act as therapeutic target of damaging agents. In this study, we found that inhibition class I histone deacetylases (HDAC) exhibited synthetic lethality with cells. Transcriptome profiling validation study showed HDAC enhanced expression thioredoxin interaction protein...
Background: As a histone demethylase, JMJD2D can enhance gene expression by specifically demethylating H3K9me2/3 and plays an important role in promoting colorectal cancer progression. However, its liver remains unclear. Methods: The of was examined human specimens non-tumorous tissues immunohistochemical or immunoblot analysis. knocked down cells using small hairpin RNAs, were analyzed with Western blot, real-time PCR, cell viability, colony formation, flow cytometry assays. Cells also...
H2A.B is a unique histone H2A variant that only exists in mammals. Here we found ubiquitously expressed major organs. Genome-wide analysis of mouse ES cells shows associated with methylated DNA gene body regions. Moreover, H2A.B-enriched loci are actively transcribed. One typical example enriched set differentially regions at imprinted and facilitates transcription elongation. These results suggest positively regulates elongation by overcoming methylation the transcribed region. It provides...
Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial LPS-induced inflammation. However, its involvement host defense against infection remains unclear. In this study, we used SRC-3 knockout mice to assess the antibacterial Escherichia coli-induced septic peritonitis. After E. coli bacteria were injected i.p., SRC-3-deficient exhibited excessive local and systemic inflammatory responses more severe burdens, leading...
Abstract SRC‐1 functions as a transcriptional coactivator for steroid receptors and various factors. Notably, has been implicated in oncogenic roles multiple cancers, including breast cancer prostate cancer. Previous investigations from our laboratory have established the high expression of human HCC specimens, where it accelerates progression by enhancing Wnt/beta‐catenin signalling. In this study, we uncover previously unknown role metastasis. Our findings reveal that promotes metastasis...
The emerging prevalence of drug-resistant
Mycoepoxydiene (MED) is a polyketide isolated from marine fungus associated with mangrove forests. MED has been shown to be able induce cell cycle arrest and cancer apoptosis. However, its effects on inflammatory response are unclear. Herein we showed that exhibited inhibitory effect induced by lipopolysaccharide (LPS). significantly inhibited LPS-induced expression of pro-inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, nitric oxide (NO) in...