A5100625399- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Kruppel-like factors research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Immune cells in cancer
- S100 Proteins and Annexins
- Advanced biosensing and bioanalysis techniques
- Metabolism and Genetic Disorders
- Computational Drug Discovery Methods
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
First Affiliated Hospital of Xiamen University
2015-2025
Xiamen University
2012-2024
Bridge University
2023
Lanzhou University
2021-2022
Northwest A&F University
2022
Collaborative Innovation Center of Chemistry for Energy Materials
2022
Fujian Medical University
2021
Central People's Hospital of Zhanjiang
2020
Daqing Oilfield General Hospital
2019
Shandong University
2012
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited. Here, we found that second-generation small molecule multi-CDK inhibitor AT7519 potential drug for GBM treatment according to high-throughput screening via Approved Drug Library Clinical Compound (2718 compounds). We significantly inhibited cell viability proliferation U87MG, U251, patient-derived cells in...
Abstract The p63 gene encodes at least six different proteins with homology to the tumour suppressor protein p53 and related family member p73. So far, there have been limited data concerning expression patterns of individual proteins, due a lack reagents that distinguish between isoforms. Three antibodies produced specifically directed against two N‐terminal isoforms (TAp63 ΔNp63) C‐terminal region p63α proteins. TAp63 are located suprabasally in stratified epithelia compared truncated...
The p21-activated kinase PAK1 is implicated in tumorigenesis, and efforts to inhibit signaling as a means induce tumor cell apoptosis are underway. However, has also been positive effector of mechanisms clonal pancreatic beta cells skeletal myotubes that would be crucial maintaining glucose homeostasis vivo. Of relevance, human islets Type 2 diabetic donors contained ∼80% less protein compared with non-diabetics, implicating islet signaling/scaffolding functions. Mimicking this, from PAK1−/−...
The coordinated immune response of the host is key successful combat body against SARS-CoV-2 infection and decisive for development progression COVID-19. In this study, we aimed to investigate whether immunological phenotype patients are associated with duration illness in severe COVID-19.In single-center 69 or critical COVID-19 were recruited retrospectively. Immunological parameters including counts white blood cells, neutrophils, lymphocytes, neutrophil-to-lymphocyte ratio, levels...
OLIG2 is a transcription factor that activates the expression of myelin-associated genes in oligodendrocyte-lineage cells. However, mechanisms myelin gene inactivation are unclear. Here, we uncover non-canonical function transcriptional repression to modulate myelinogenesis by functionally interacting with tri-methyltransferase SETDB1. Immunoprecipitation and chromatin-immunoprecipitation assays show recruits SETDB1 for H3K9me3 modification on Sox11 gene, which leads inhibition during...
Abstract Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is major genetic risk factor for Alzheimer’s and cardiovascular diseases. Although has recently been associated with increased susceptibility to infections of several viruses, whether how its isoforms affect SARS-CoV-2 infection remains unclear. Here, we show that serum concentrations correlate inversely levels cytokine/chemokine 73 COVID-19 patients. Utilizing multiple...
Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor efficacy. Targeted radionuclide therapy delivers radiation directly to tumor sites. LNC1004 is a fibroblast activation protein (FAP)-targeting radiopharmaceutical, conjugated the albumin binder Evans Blue, which has demonstrated enhanced uptake and retention in previous preclinical clinical studies. Herein, we demonstrate that
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Drug delivery to brain through blood-brain barrier (BBB) a significant challenge in PD treatment. Exosomes, which can efficiently traverse BBB, many drugs cannot penetrate, are ideal natural carriers for drug delivery. In this study, BBB shuttle peptide was modified on exosome surfaces. Three types of exosomes were constructed, each with distinct (RVG29, TAT, or Ang2) and loaded miR-133b. The safety...
Background Combined pulmonary fibrosis and emphysema (CPFE) commonly coexists with connective tissue diseases (CTD), such as rheumatoid arthritis (RA). However, the risk factors contributing to development of CTD-CPFE remain largely unidentified. This study aimed characterize CPFE using a large cohort consecutive RA patients elucidate potential associated RA- development. Methods A total 976 were enrolled in this cross-sectional RA-CPFE. Multiple logistic analyses conducted identify for...
Addressing the spread of coronavirus disease 2019 (COVID-19) has highlighted need for rapid, accurate, and low-cost diagnostic methods that detect specific antigens SARS-CoV-2 infection. Tests COVID-19 are based on reverse transcription PCR (RT-PCR), which requires laboratory services is time-consuming. Here, by targeting spike protein, we present a point-of-care SERS detection platform specifically detects antigen in one step captureing substrates probes aptamer-specific recognition. Using...
Highlights•Matrilin-3 decreases in both animal brains and patient serum with ischemic stroke•Matrilin-3 protects brain by suppressing astrocytic inflammation•Extracellular matrilin-3 enters astrocytes via CAV1-mediated endocytosis•Matrilin-3 binds to NF-κB p65 or extracellular BMP-2 inhibit neuroinflammationSummaryIn the brain, role of matrilin-3, an matrix component cartilage, is unknown. Here, we identify that decreased reactive but was unchanged neurons after stroke animals. Importantly,...
Autophagy is a potentially inimical pathway and together with apoptosis, may be activated by similar stress stimuli that can lead to cell death. The molecular cues dictate the fate choice between autophagy apoptosis remain largely unknown. Here we report proapoptotic protein BBC3/PUMA (BCL2 binding component 3) bona fide substrate of chaperone-mediated (CMA). BBC3 associates HSPA8/HSC70 (heat shock 70kDa 8), leading its lysosome translocation uptake. Inhibition CMA results in stabilization...
Abstract Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, role in formation astrogliosis glial scar remains unknown. Here, a transient middle cerebral artery occlusion (tMCAO) rat model an oxygen glucose deprivation reoxygenation (OGD/Re)-induced injury model, we show was significantly elevated reactive...
Due to the non-invasiveness and high precision of electroencephalography (EEG), combination EEG artificial intelligence (AI) is often used for emotion recognition. However, internal differences in data have become an obstacle classification accuracy. To solve this problem, considering labeled from similar nature but different domains, domain adaptation usually provides attractive option. Most existing researches aggregate subjects sessions as a source domain, which ignores assumption that...
Abstract Background Mutations in colony-stimulating factor 1 receptor (CSF1R) are known to cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which has been recently demonstrated as a primary microgliopathy characterized by cognitive impairment. Although the molecular mechanism underlying CSF1R-mediated remains unclear, therapeutic strategies have generally targeted modulation of microglial function. In particular, inhibitor, minocycline, shown attenuate...
Introduction Gut-microbiota-brain axis is a potential treatment to decrease the risk of chronic traumatic encephalopathy following brain injury (TBI). Phosphoglycerate mutase 5 (PGAM5), mitochondrial serine/threonine protein phosphatase, resides in membrane and regulates homeostasis metabolism. Mitochondria mediates intestinal barrier gut microbiome. Objectives This study investigated association between PGAM5 microbiota mice with TBI. Methods The controlled cortical impact was established...
Abstract Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, clinical use of TMZ limited by its various side effects and resistance to chemotherapy. The present study revealed synergistic inhibition glioblastoma through combined administration perifosine. This combination therapy markedly diminished BRCA1 expression, resulting in suppression DNA repair mechanisms. Furthermore, perifosine elicited caspase-dependent apoptosis,...
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, exclusive substrate for synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in and remodels production synthesis. Firstly, acetate an important glioblastoma. phosphorylates synthetase ACSS2 at Tyr530 Tyr562 to stimulate conversion cytosol. Secondly, inhibits citrate-derived by phosphorylating ATP-citrate lyase...
Aims: Traumatic brain injury (TBI) is a major cause of disability and death, better understanding the underlying mechanisms mitochondrial dysfunction will provide important targets for preventing damage from neuronal insults. Phosphoglycerate mutase 5 (PGAM5) localized to outer-inner membrane contact sites, PGAM5-Drp1 pathway involved in cell death. The purpose this project was evaluate effects PGAM5 on dysfunction. Results: overexpressed mice subjected TBI primary cortical neurons injured...
Dysfunction of protein trafficking has been intensively associated with neurological diseases, including neurodegeneration, but whether and how transport contributes to oligodendrocyte (OL) maturation myelin repair in white matter injury remains unclear. ER-to-Golgi newly synthesized proteins is mediated by coat complex II (COPII). Here, we demonstrate that the COPII component Sec13 was essential for OL differentiation postnatal myelination. Ablation lineage prevented OPC inhibited...
Conversion of astroglia into functional neurons has been considered a promising therapeutic strategy for neurodegenerative diseases. Recent studies reported that downregulation the RNA binding protein, polypyrimidine tract-binding protein 1 (PTBP1), converts astrocytes <i>in situ</i> in multiple mouse brain regions, consequently improving pathologic phenotypes associated with Parkinson9s disease, RGC loss, and aging. Here, we demonstrate PTBP1 using an astrocyte-specific AAV-mediated shRNA...