A5103230495- Pancreatic function and diabetes
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cannabis and Cannabinoid Research
- Management of metastatic bone disease
- Dietary Effects on Health
- Circular RNAs in diseases
- Diabetes Management and Research
- Genetics and Neurodevelopmental Disorders
- RNA Interference and Gene Delivery
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cardiovascular Health and Risk Factors
- Cancer-related molecular mechanisms research
- Pharmacological Effects and Toxicity Studies
- Nerve injury and regeneration
- Blood groups and transfusion
- Anatomy and Medical Technology
- Hormonal and reproductive studies
- Blood donation and transfusion practices
- Spinal Cord Injury Research
- Connective Tissue Growth Factor Research
- Immunotherapy and Immune Responses
- Chronic Kidney Disease and Diabetes
- Sexual Differentiation and Disorders
Guangxi University of Chinese Medicine
2011-2025
Ruikang Affiliated Hospital of Guangxi Medical University
2019-2025
Guangxi University
2023-2024
Guangxi Center for Disease Prevention and Control
2023-2024
Academy of Military Medical Sciences
2015-2016
Luohe Medical College
2009
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Drug delivery to brain through blood-brain barrier (BBB) a significant challenge in PD treatment. Exosomes, which can efficiently traverse BBB, many drugs cannot penetrate, are ideal natural carriers for drug delivery. In this study, BBB shuttle peptide was modified on exosome surfaces. Three types of exosomes were constructed, each with distinct (RVG29, TAT, or Ang2) and loaded miR-133b. The safety...
Objective This study aimed to explore the association between weekend catch-up sleep (WCS) and chronic kidney disease (CKD) in American adults.
Social determinants of health (SDOH) and metabolic syndrome (MetS) are related, but their combined effect on mortality risk remains unclear. We analyzed data from NHANES (National Health Nutrition Examination Survey) cycles between 2005 2018. The composite SDOH score was calculated by summing the weighted scores for each SDOH, categorizing participants into four groups: Q1 (0-1), Q2 (2-3), Q3 (4) Q4 (≥ 5). Kaplan-Meier survival curves multivariate Cox proportional hazards models were used to...
To analyze changes in immune functions by detecting lymphocyte subsets the peripheral blood of residents vicinity radon from hot springs.Two groups were randomly selected; 61 springs assigned to group, and 51 with a similar lifestyle habits but no contact control group. The percentages (CD3+, CD4+CD8-, CD4-CD8+, CD4+/CD8+, TCR/CD3) 2 evaluated on FACS Aria flow cytometer. absolute values lymphocytes (LYMPH#) (LYMPH%) measured an automatic analyzer.In numbers CD3+ (Z = -0.140, P > .05)...
Engagement of programmed death 1 receptor (PD-1) and its ligand PD-L1/2 induces a signal transduction pathway that inhibits the activity tumor-infiltrating cytotoxic T lymphocytes promotes tumor growth metastasis. Antibodies blocking PD-1 or PD-L1 can restore antitumor cell responses cause long-term remission in subset cancer patients with advanced refractory tumors. In this study, we asked whether vaccination could confer control mouse models. To address central tolerance toward...
Islet cell transplantation is an emerging therapy in the treatment of diabetes mellitus. Differentiation islet cells from mesenchymal stem (MSCs) a potential solution to challenge insufficient donor sources. This study investigated whether human umbilical cord-derived MSCs could effectively differentiate into insulin-producing (IPCs) and evaluated therapeutic efficacy IPCs treating diabetes. were induced by two-step protocol. IPC expression products western blot real-time PCR. insulin...
Islet transplantation (IT) has emerged as a significant research area for the treatment of diabetes mellitus and witnessed surge in scholarly attention. Despite its growing importance, there is lack bibliometric analyses that encapsulate evolution scientific underpinnings this field. This study aims to fill gap by conducting comprehensive analysis delineate current hotspots forecast future trajectories within IT domain with particular focus on evidence-based medicine practices.
Islet transplantation may be the most efficient therapeutic technique for patients with type 1 diabetes mellitus (T1DM). However, clinical application of this method is faced numerous limitations, including isolated islet apoptosis, recipient rejection, and graft vascular reconstruction. Mesenchymal stem cells (MSCs) possess anti-apoptotic, immunomodulatory, angiogenic properties. Here, we review recent studies on co-culture co-transplantation islets MSCs. We have summarized methods...
Several clinical features have been proposed for the prediction of postoperative functional outcome in patients with metastatic epidural spinal cord compression (MESCC). However, few articles address relationship between preoperative imaging characteristics and neurologic status.This study aims to analyze identify new parameters predicting status MESCC.This is a retrospective consecutive case series MESCC who were treated surgically.We assessed 81 decompressive surgery 2013 2015.Eight...
Lung adenocarcinoma can be accompanied by epidermal growth factor receptor (EGFR) mutation. As a consequence, targeted therapy based on screening of tyrosine-kinase inhibitors (TKIs) is necessary. Spinal cord metastasis lung cancer serious clinical problem. Here, we report case with severe spinal that was successfully treated second administration an EGFR-TKI. Magnetic resonance imaging showed to the cervical vertebrae. The patient received EGFR-TKI (150 mg/day erlotinib). Four months later,...
Abstract Aims Our team tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal (mice, rats, and beagles) models with complete transection. To further explore application of SCF for treatment paraplegic patients, we developed a new clinical procedure called vascular pedicle hemisected transplantation (vSCT) this eight participants. Methods Eight participants (American Spinal Injury Association, ASIA: A) were enrolled treated vSCT (PEG was...
Single nucleotide polymorphisms (SNPs) have been inconsistently associated with osteosarcoma (OS) risk. This meta-analysis aimed to synthesize relevant data on SNPs OS.Databases were searched identify association studies of and OS published through January 2020 from the databases PubMed, Web Science, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Science Technology Periodical Database, Wan fang databases. Network Thakkinstian algorithm used select most appropriate...
Abstract: Exosomal-microRNAs (Exo-miRNAs) are key regulators of islet cell function, including insulin expression, processing, and secretion. Exo-miRNAs have a significant impact on the outcomes transplantation as biomarkers for evaluating function survival. Furthermore, they been linked to vascular remodeling immune regulation following transplantation. Mesenchymal stem cell-derived exosomes shown in preliminary studies improve viability when injected or transplanted into mice. Overall,...
Congenital adrenal hyperplasia (CAH) is increasingly prevalent, leading to a surge in related research. To pinpoint emerging trends and recommend future directions, bibliometric analysis of relevant CAH literature was performed.
A 48-year-old Chinese female was referred to us regarding EGFR-mutated advanced non-small cell lung cancer, and metastasis left scapula vertebrae bones which caused pathological fracture at T8 T10 thoracic vertebrae. An aggressive combined therapy with icotinib, operation, radioactive particle implantation immunotherapy proposed prevent paraplegia, relieve pain, control the overall local tumor lesions. No postoperative symptoms were seen after surgery, pain significantly relieved. Icotinib...
We elaborate on the retrospective analysis of clinical data a patient afflicted with grand mal seizures following kidney transplant. The 16-year-old female was hospitalized for chronic glomerulonephritis. She experienced an epileptic seizure and treated carbamazepine. Renal transplantation performed; function transplant normal. However, seizures, which required intravenous luminal intramuscular diazepam injections control, began fourth postoperative day lasted 3 days, occurring approximately...