A5103008156- Plant Molecular Biology Research
- Nitric Oxide and Endothelin Effects
- Peanut Plant Research Studies
- Plant Gene Expression Analysis
- Coconut Research and Applications
- Renin-Angiotensin System Studies
- Plant Virus Research Studies
- Immunotherapy and Immune Responses
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Blood Pressure and Hypertension Studies
- Plant Physiology and Cultivation Studies
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Chromosomal and Genetic Variations
- Plant biochemistry and biosynthesis
- Cancer Immunotherapy and Biomarkers
- Postharvest Quality and Shelf Life Management
- Hormonal Regulation and Hypertension
- CAR-T cell therapy research
- Lipid metabolism and biosynthesis
- Light effects on plants
- Genomics and Chromatin Dynamics
- Cassava research and cyanide
Guangxi Medical University
2025
Huazhong Agricultural University
2010-2024
First People's Hospital of Yunnan Province
2024
China Agricultural University
2024
Beijing Academy of Agricultural and Forestry Sciences
2024
Stomatology Hospital
2024
Guangzhou Medical University
2024
Changzhou No.2 People's Hospital
2024
Nanjing Medical University
2024
Affiliated Hospital of Southwest Medical University
2024
Abstract Epigenomic modifications are instrumental for transcriptional regulation, but comprehensive reference epigenomes remain unexplored in rice. Here, we develop an enhanced chromatin immunoprecipitation (eChIP) approach plants, and generate genome-wide profiling of five histone RNA polymerase II occupancy with it. By integrating accessibility, DNA methylation, transcriptome datasets, construct epigenome landscapes across various tissues 20 representative rice varieties. Approximately...
Abstract Programmed cell death (PCD) during tapetum degeneration in postmeiotic anthers is critical for the proper development of male gametophytes flowering plants. Although several genes involved this process have been identified recently, molecular mechanism still poorly understood. Here, we show that knockout rice (Oryza sativa) APOPTOSIS INHIBITOR5 (API5), which encodes a putative homolog antiapoptosis protein Api5 animals, results delayed due to inhibition tapetal PCD leading defects...
It is challenging to determine the effect of DNA methylation on epigenetic landscape and function in higher organisms due lack methylation-free mutants.
Testa color is an important trait of peanut (Arachis hypogaea L.) which closely related with the nutritional and commercial value. Pink red are main testa. However, genetic mechanism testa regulation in not fully understood. To elucidate a clear picture regulatory model, samples pink cultivar (Y9102), (ZH12), two RNA pools (bulk bulk pink) constructed from F4 lines Y9102 x ZH12 were compared through RNA-seq approach.A total 2992 differential expressed genes (DEGs) identified among 317 1334...
Objective To investigate the effects on resistance artery structure and function of monotherapy with β-blocker atenolol or calcium channel antagonist nifedipine in its once a day form gastrointestinal therapeutic system (GITS). Subjects Twenty well-controlled essential hypertensive patients matched for age, body mass index, duration severity hypertension. Normotensive subjects untreated hypertensives served as reference groups. Methods Resistance-size small arteries (standardized lumen...
Background Endothelins are potent vasoconstrictors, and may also act as mitogens hypertrophic agents. Expression of a member this family peptides, endothelin-1, is enhanced in the endothelium blood vessels rats with severe forms hypertension, even absence elevated plasma endothelin levels. In some these hypertensive models endothelin-1 gene expression contribute to vascular hypertrophy small arteries elevation pressure. Objective To establish whether play role essential hypertension humans,...
Peanut (Arachis hypogaea. L) is an important oil crop worldwide. The common testa colours of peanut varieties are pink or red. But the with dark purple have been focused in recent years due to potential high levels anthocyanin, added nutritional value antioxidant. However, genetic mechanism regulating colour unknown. In this study, we found that was decided by female parent and controlled a single major gene named AhTc1. To identify candidate controlling testa, whole-genome...
The full potential of tumor-infiltrating lymphocyte (TIL) therapy has been hampered by the inadequate activation and low persistence TILs, as well inefficient neoantigen presentation tumors. We transformed tumor cells into artificial antigen-presenting (aAPCs) infecting them with a herpes simplex virus 1 (HSV-1)-based oncolytic encoding OX40L IL12 (OV-OX40L/IL12) to provide local signals for optimum T cell activation. infected displayed increased expression cell-related markers induced...
Although spatial organization of compartments and topologically associating domains at large scale is relatively well studied, the regulatory elements fine poorly understood in plants.
The elucidation of gastric inhibitory polypeptide-dependent Cushing's syndrome suggested that ectopic expression or increased responsiveness other adrenal hormone receptors may underlie ACTH-independent macronodular hyperplasia (AIMAH) adrenocortical tumors. We studied a 36-yr-old woman with syndrome, AIMAH, and orthostatic hypotension. During upright posture, cortisol aldosterone were stimulated despite suppression ACTH renin. Arginine vasopressin (AVP, 10 U im), under dexamethasone...
Previous studies have shown an impairment of responsiveness resistance arteries to endothelin-1 in experimental hypertensive rats. This study was undertaken demonstrate whether responses were also blunted adult 20-week-old spontaneously rats (SHR). Resistance from the mesenteric vascular bed exhibited normal active tension and arginine vasopressin, exaggerated norepinephrine. Since media thicker SHR, stress vasopressin significantly impaired, while norepinephrine similar SHR Wistar-Kyoto...
The transition from vegetative to reproductive growth is a critical process in the life cycle of higher plants. Previously, we cloned Rice Indeterminate 1 (RID1), which acts as master switch for phase rice. Although photoperiod pathway RID1 inducing expression florigen genes Hd3a and RFT1 via Ehd1 has been established, alternative pathways essential flowering need be further examined. Here, identified Suppressor rid1 (SID1), rescues never-flowering phenotype rid1. SID1 encodes an...
Peanuts with high oleic acid content are usually considered to be beneficial for human health and edible oil storage. In breeding practice, peanut lines monounsaturated fatty acids selected using desaturase 2 (FAD2), which is responsible the conversion of (C18:1) linoleic (C18:2). Here, comparative transcriptomics were used analyze global gene expression profile high- normal-oleic cultivars at six time points during seed development. First, mutant type FAD2 was determined in high-oleic...
Modern peanut contains fatty acid desaturase 2 (FAD2) mutation, which is capable of producing high oleic for human health. However, the dynamic changes lipidome regarding fad2 remain elusive in seed. In present study, 547 lipid features were identified high- and normal-oleic seeds by utilizing mass spectrometric approach. The fad2-induced differently expressed lipids (DELs) polarly distributed at early maturation stages during high-oleic (OA) seed development. Subsequently, integration...
Abstract Background The daily cycling of plant physiological processes is speculated to arise from the coordinated rhythms gene expression. However, dynamics diurnal 3D genome architecture and their potential functions underlying rhythmic expression remain unclear. Results Here, we reveal genome-wide occupancy RNA polymerase II (RNAPII), which precedes mRNA accumulation by approximately 2 h. Rhythmic RNAPII binding dynamically correlates with RNAPII-mediated chromatin remodeling at genomic...
COX20-related mitochondrial complex IV deficiency is a rare autosomal recessive metabolic disorder that arises from biallelic loss-of-function mutations. Given the lack of specific treatments, affected children are at heightened risk disability. Consequently, prenatal counseling and diagnosis should be conducted to reduce birth rate with such diseases. We report case COX20 gene associated in child, describe mother subsequent pregnancies provide reference for this disease. In study, we...
The study aimed to enhance the shelf life of fresh‐cut strawberries and dragon fruits by understanding their respiration behavior under modified atmosphere packaging (MAP) conditions, an essential factor in improving fruit preservation. Using a closed system at 4 ± 0.5 ° C, we examined dynamics these developed mathematical model based on Michaelis–Menten enzymatic kinetics predict rates. findings revealed that exhibited higher maximum rates ( V m ) than fruit, with fermentation threshold...
1. Chronic treatment with a combined ETA/ETB endothelin receptor antagonist has been shown to reduce blood pressure in experimental rat models of hypertension which endothelin-1 gene overexpression occurs the walls vessels, particularly small, resistance-sized arteries, but not those genetic or there is no vascular endothelin-1. Failure some respond may be due part blockade vasorelaxant endothelial ETB receptors could theory efficacy antagonism. 2. In this study orally active ETA-selective...
To determine whether inhibition of generation endothelium-derived relaxing factor or nitric oxide (NO) resulted in elevated blood pressure and its effect on resistance arteries, rats were offered NG-nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor NO synthase, their drinking water. Blood (BP) rose slightly from 100 ± 2 mmHg controls to 130 5 with 25 mg/Kg L-NAME per day 173 9 for 1/2 4 weeks. Rats studied after 1–2 weeks hypertension (BP> 150 mmHg). The concentration cyclic...
Sulfonylurea (SU) herbicides inhibit branched-chain amino acid (BCAA) biosynthesis by targeting acetolactate synthase. Plants have evolved target-site resistance and metabolic tolerance to SU herbicides; the GCN2 (general control non-repressible 2) pathway is also involved in tolerance. Here, we report a novel mechanism, autophagy, which call 'homeostatic tolerance,' signaling Arabidopsis. The activation reversion of autophagy herbicide tribenuron-methyl (TM) exogenous BCAA, respectively,...
Peanuts (Arachis hypogaea L.) are an important oilseed crop, containing high contents of protein and fatty acids (FA). The major components FA found in peanut oil unsaturated FAs, including oleic acid (OA, C18:1) linoleic (LOA, C18:2). Moreover, the content OA is beneficial for human health long-term storage due to its antioxidant activity. However, dynamic changes proteomics related accumulation during seed development still remain largely unexplored. In present study, a comparative...
Photoperiods integrate with the circadian clock to coordinate gene expression rhythms and thus ensure plant fitness environment. Genome-wide characterization comparison of rhythmic genes under different light conditions revealed delayed phase constant darkness (DD) reduced amplitude (LL) in rice. Interestingly, ChIP-seq RNA-seq profiling exhibit synchronous oscillation H3K9ac modifications at their loci long non-coding RNAs (lncRNAs) proximal loci. To investigate how rhythm is regulated...