A5100721817- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Cancer Research and Treatments
- Esophageal Cancer Research and Treatment
- Polysaccharides and Plant Cell Walls
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Organic Light-Emitting Diodes Research
- Breast Lesions and Carcinomas
- Plant nutrient uptake and metabolism
- Microbial Metabolites in Food Biotechnology
- Viral Infections and Vectors
- Genetic Mapping and Diversity in Plants and Animals
- Immune cells in cancer
- Animal Virus Infections Studies
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
Nankai University
2006-2025
Beijing Hospital of Traditional Chinese Medicine
2025
Capital Medical University
2025
Wuhan University
2025
Hebei University of Technology
2025
ShanghaiTech University
2017-2024
National Vaccine and Serum Institute
2022-2024
State Key Laboratory of Food Science and Technology
2023-2024
Henan Cancer Hospital
2017-2024
Zhengzhou University
2017-2024
Abstract COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against can provide an important treatment option to fight COVID-19, especially for the most vulnerable populations. In this work, potent binding Spike protein were identified from convalescent patients. Among them, P4A1 interacts directly and covers majority of Receptor Binding Motif Receptor-Binding Domain, shown high-resolution complex...
Microfluidics system enables high-throughput functional screening of antibodies for cancer immunotherapy.
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries worldwide. high number spike mutations responsible for broad immune evasion from existing vaccines and antibody drugs. To understand this, we first present cryo-electron microscopy structure ACE2-bound spike. Comparison to previous structures explains how escapes these therapeutics. Secondly, report Omicron, Delta, wild-type spikes bound a patient-derived Fab fragment (510A5), which provides direct evidence where...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide. Despite promising outcome immune checkpoint inhibitors and agonist antibody therapies in different malignancies, PDAC exhibits high resistance due to its immunosuppressive tumor microenvironment (TME). Ameliorating TME thus a rational strategy for therapy. The intratumoral application oncolytic herpes simplex virus-1 (oHSV) upregulates pro-inflammatory macrophages lymphocytes TME, enhances responsiveness...
Abstract Room‐temperature phosphorescent (RTP) materials have great potential for in vivo imaging because they can circumvent the autofluorescence of biological tissues. In this study, a class organic‐doped long‐wavelength (≈600 nm) RTP with benzo[c][1,2,5] thiadiazole as guest was constructed. Both host and molecules simple structures be directly purchased commercially at low cost. Owing to long phosphorescence wavelength doping system, it exhibited good tissue penetration (10 mm). Notably,...
Abstract Despite the promise in whole‐tumor cell vaccines, a key challenge is to overcome lack of costimulatory signals. Here, agonistic‐antibody‐boosted tumor nanovaccines are reported by genetically engineered antibody‐anchored membrane (AAM) technology, capable effectively activating pathways. Specifically, AAM can be stably constructed following genetic engineering membranes with anti‐CD40 single chain variable fragment (scFv), an agonistic antibody induce The versatilely designed and...
Rationale: The resistance of pancreatic ductal adenocarcinoma (PDAC) to immunotherapies is caused by the immunosuppressive tumor microenvironment (TME) and dense extracellular matrix. Currently, efficacy an isolated strategy targeting stromal desmoplasia or immune cells has been met with limited success in treatment cancer. Oncolytic virus (OV) therapy can remodel TME damage either directly killing them enhancing anti-tumor response, which holds promise for PDAC. This study aimed investigate...
A multifunctional nanocarrier with multilayer core–shell architecture was prepared by alkaline coprecipitation of ferric and ferrous ions in the presence a triblock copolymer, methoxy poly(ethylene glycol)-block-poly(methacrylic acid)-block-poly(glycerol monomethacrylate) (denoted MPEG-b-PMAA-b-PGMA), aqueous solution. The core is superparamagnetic Fe3O4 nanoparticle, on which PGMA block copolymer attached. PMAA forms inner shell MPEG outermost shell. anticancer agent adriamycin (ADR), as...
The study of yield traits can reveal the genetic architecture grain for improving maize production. In this study, an association panel comprising 362 inbred lines and a recombinant line population derived from X178 × 9782 were used to identify candidate genes nine traits. High-priority overlap (HPO) genes, which are prioritized in genome-wide (GWAS), investigated using coexpression networks. GWAS identified 51 environmentally stable SNPs two environments 36 pleiotropic SNPs, including three...
The full potential of tumor-infiltrating lymphocyte (TIL) therapy has been hampered by the inadequate activation and low persistence TILs, as well inefficient neoantigen presentation tumors. We transformed tumor cells into artificial antigen-presenting (aAPCs) infecting them with a herpes simplex virus 1 (HSV-1)-based oncolytic encoding OX40L IL12 (OV-OX40L/IL12) to provide local signals for optimum T cell activation. infected displayed increased expression cell-related markers induced...
Pancreatic ductal adenocarcinoma (PDAC) is the major type of pancreatic malignancy with very poor prognosis. Despite promising results immune checkpoint inhibitors (ICIs) in some solid tumors, immunotherapy less effective for PDAC due to its immunosuppressive tumor microenvironment (TME). In this report, we established an immunocompetent syngeneic model and investigated effect oncolytic herpes simplex virus-1 (oHSV) on composition TME cells. The oHSV treatment significantly reduced burden...
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring accelerating development of prophylactic therapeutic interventions. Molecular understanding neutralizing antibodies (NAbs) would greatly help advance the monoclonal antibody (mAb) therapy, as well design next generation recombinant vaccines. Here, we applied H2L2 transgenic mice encoding human immunoglobulin...
Abstract Modulating macrophages presents a promising avenue in tumor immunotherapy. However, cells have evolved mechanisms to evade macrophage activation and phagocytosis. Herein, we introduced bispecific antibody-based nanoengager facilitate the recognition phagocytosis of by macrophages. Specifically, genetically engineered two single chain variable fragments (scFv) onto cell membrane: anti-CD40 scFv for engaging with anti-Claudin18.2 (CLDN18.2) interacting cells. These nanoengagers were...
Follistatin-like 1 (FSTL1) is a matricellular protein that upregulated during development and disease, including idiopathic pulmonary fibrosis (IPF), keloid, arthritis. The profibrotic pro-inflammatory roles of FSTL1 have been intensively studied the last several years, as well in this report. We screened identified epitope-specific monoclonal neutralizing antibodies (nAbs) to functionally block FSTL1. nAbs attenuated bleomycin-induced dermal vivo transforming growth factor (TGF)-β1-induced...
Using a field experiment on Pandora Media, the researchers show that one can increase subscription profits by 7% personalizing ad load across users without decreasing profits.
To summarize the clinical features and ultrasonic characteristics of patients with cystic neutrophilic granulomatous mastitis (CNGM), to enhance understanding CNGM in practice.
This study aims to identify self-management behavior profiles in multimorbid patients, and explore how workload, capacity, their interactions influence these profiles. A sequential explanatory mixed-methods design was employed. In the quantitative phase (August 2022 May 2023), data were collected from 1,920 patients across nine healthcare facilities Zhejiang Province. Latent Profile Analysis (LPA) used distinct Multinomial logistic regression then assess of workload capacity dimensions...
Abstract Phonon modal nonequilibrium is believed to widely exist around nanoscale hotspots, which can significantly affect the performance of nano‐electronic and optoelectronic devices. However, such a phenomenon has not been explicitly observed in 3D device semiconductors at nanoscale. Here, by employing tip‐enhanced Raman thermal measurement approach, substantial phonon gallium nitride near sub‐10 nm laser‐excited hotspots directly revealed for first time. As further evidence, quantitative...
This study aimed to explore the diagnostic value of two cytology techniques, including liquid-based mammary ductal lavage fluid and nipple discharge smear cytology, in intraductal lesions patients with pathological (PND). retrospective analysis included 119 PND who underwent surgical treatment. At same time, they all fiberoptic ductoscopy (FDS), before surgery. With postoperative diagnosis as gold standard, we compared clinical efficacy techniques applied independently combined FDS evaluate...
Background Ten cases with Dabie bandavirus infection were identified in Suzhou City, China, from April 2023 to August 2024. All 10 hospitalized patients, and three died. We detected analyzed the cytokine concentrations viral genomes serum samples of these patients identify possible causes patients’ deaths analyze genetic characteristics. Methods Blood specimens obtained individuals City. The specific nucleic acid was using a real-time reverse transcription polymerase chain reaction assay...