A5031402900- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Photodynamic Therapy Research Studies
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Single-cell and spatial transcriptomics
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Biomarkers in Disease Mechanisms
Nankai University
2024
State Key Laboratory of Medicinal Chemical Biology
2024
Ludwig-Maximilians-Universität München
2024
Institute for Sports Medicine
2024
University of California, Davis
2022
Abstract Modulating macrophages presents a promising avenue in tumor immunotherapy. However, cells have evolved mechanisms to evade macrophage activation and phagocytosis. Herein, we introduced bispecific antibody-based nanoengager facilitate the recognition phagocytosis of by macrophages. Specifically, genetically engineered two single chain variable fragments (scFv) onto cell membrane: anti-CD40 scFv for engaging with anti-Claudin18.2 (CLDN18.2) interacting cells. These nanoengagers were...
Abstract Background Arterial macrophages play an important role in atherosclerosis, exhibiting heterogeneity their origins as either resident or inflammatory monocyte-derived macrophages. Resident originate predominantly from the yolk sac, and they are endowed with homeostatic functions can have anti-inflammatory properties under inflammation [1]. pre-existing within tissue differentiate into foamy before monocytes appear early atherosclerotic lesions [2]. Galectin-3 (Gal-3) encoded by gene...
<h3>Background</h3> Immune checkpoint inhibitors (ICIs) in general have shown poor efficacy bladder cancer (BCa). The purpose of this project is to determine whether photodynamic therapy (PDT) with BCa-specific porphyrin-based PLZ4-nanoparticles (PNP) potentiated ICI. <h3>Materials and Methods</h3> SV40 T/Ras double-transgenic mice bearing orthotopic BCa C57BL/6 carrying syngeneic models were used the conduct molecular correlative studies. <h3>Results</h3> PDT PNP generated reactive oxygen...