A5100432303- Plant Molecular Biology Research
- RNA modifications and cancer
- Peanut Plant Research Studies
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- RNA and protein synthesis mechanisms
- Plant tissue culture and regeneration
- Plant Virus Research Studies
- Coconut Research and Applications
- Nitrogen and Sulfur Effects on Brassica
- Plant Genetic and Mutation Studies
- Plant-Microbe Interactions and Immunity
- Plant Stress Responses and Tolerance
- Plant Disease Resistance and Genetics
- Plant biochemistry and biosynthesis
- RNA Research and Splicing
- Plant Reproductive Biology
- Microbial Metabolic Engineering and Bioproduction
- Light effects on plants
- Gastric Cancer Management and Outcomes
- Virus-based gene therapy research
- Cancer-related gene regulation
- Soil erosion and sediment transport
- Cancer-related molecular mechanisms research
- Seed Germination and Physiology
Shandong Academy of Agricultural Sciences
2017-2024
Anhui University of Science and Technology
2024
Shandong University of Technology
2024
Indiana University Bloomington
2024
Institute of Zoology
2023
Chinese Academy of Sciences
2023
Shandong Normal University
2019-2022
Czech Academy of Sciences, Institute of Biotechnology
2022
Biotechnology Research Center
2018-2021
First Affiliated Hospital of Chengdu Medical College
2021
tsRNAs (tRNA-derived small RNAs), as products of the stress response, exert considerable influence on response and injury regulation. However, it remains largely unclear whether can ameliorate liver injury. Here, we demonstrate roles in alleviating by utilizing loss NSun2 (NOP2/Sun domain family, member 2) a tsRNAs-generating model. Mechanistically, reduces methyluridine-U5 (m5U) cytosine-C5 (m5C) tRNAs, followed production various tsRNAs, especially Class I (tRF-1s). Through further...
Peanut (Arachis hypogaea. L) is an important oil crop worldwide. The common testa colours of peanut varieties are pink or red. But the with dark purple have been focused in recent years due to potential high levels anthocyanin, added nutritional value antioxidant. However, genetic mechanism regulating colour unknown. In this study, we found that was decided by female parent and controlled a single major gene named AhTc1. To identify candidate controlling testa, whole-genome...
Heat shock transcription factors (Hsfs) are important (TFs) in protecting plants from damages caused by various stresses. The released whole genome sequences of wild peanuts make it possible for genome-wide analysis Hsfs peanut. In this study, a total 16 and 17 Hsf genes were identified Arachis duranensis A. ipaensis, respectively. We orthologous gene pairs both peanut species; however HsfXs was only ipaensis. Orthologous between two species highly syntenic. Based on phylogenetic...
BACKGROUND The coiled-coil domain-containing proteins have been shown to a series of functions in biological synthesis. Recent studies found that CCDC34 is highly expressed bladder cancer, but the underlying molecular mechanisms still remain unclear. Therefore, we performed present study assess expression protein 34 (CCDC34) esophageal squamous cell carcinoma (ESCC) patients. We also explored relationships between and clinicopathologic characteristics, tumor angiogenesis, prognosis. MATERIAL...
Abstract Maize rough dwarf disease, caused by rice black-streaked virus (RBSDV), is a devastating disease in maize ( Zea mays L.). MicroRNAs (miRNAs) are known to play critical roles regulation of plant growth, development, and adaptation abiotic biotic stresses. To elucidate the miRNAs response RBSDV, we employed high-throughput sequencing technology analyze miRNAome transcriptome following RBSDV infection. A total 76 miRNAs, 226 potential novel 351 target genes were identified. Our dataset...
LEAFY COTYLEDON 2 (LEC2) acts throughout embryo morphogenesis and maturation phase to maintain embryogenic identity. Our previous study stated that Arabidopsis thaliana LEC2 (AtLEC2) driven by glucocorticoid receptor-dexamethasone (GR-DEX) inducible system (AtLEC2-GR) triggers callus formation in tobacco (Nicotiana tabacum).In this study, the adenosine phosphate isopentenyltransferase genes AtIPT3, AtIPT7 tRNA gene AtIPT9 were overexpressed AtLEC2-GR transgenic background. In AtIPT7-OE...
Ribosome biogenesis is an orchestrated process that relies on many assembly factors. The AAA-ATPase Midasin 1 (Mdn1) functions as a ribosome factor in yeast (Saccharomyces cerevisiae), but the roles of MDN1 Arabidopsis (Arabidopsis thaliana) are poorly understood. Here, we showed null mutant embryo-lethal. Using weak mdn1-1, which maintains viability, found critical for regular pattern auxin maxima globular embryo and root meristem maintenance. By detecting subcellular distribution proteins,...
Abstract Background MicroRNAs are important gene expression regulators in plants immune system. Aspergillus flavus is the most common causal agents of aflatoxin contamination peanuts, but information on function miRNA peanut- A. interaction lacking. In this study, resistant cultivar (GT-C20) and susceptible (Tifrunner) were used to investigate regulatory roles miRNAs response growth . Results A total 30 miRNAs, 447 genes 21 potential miRNA/mRNA pairs differentially expressed significantly...
Abstract The chloroplast-localized proteins play roles in plant salt stress response, but their mechanisms remain largely unknown. In this study, we screened a yellow leaf mutant, yl1-1 , whose shoots exhibited hypersensitivity to stress. We mapped YL1 AT3G57180, which encodes YqeH-type GTPase. YL1, as chloroplast stroma-localized protein, could be markedly reduced by high salinity. Upon exposure salinity, seedling of and yl1-2 accumulated significantly higher levels Na + than wild type....
Systemic acquired resistance is an essential immune response that triggers a broad-spectrum disease throughout the plant. In present study, we identified peanut lesion mimic mutant m14 derived from ethyl methane sulfonate-mutagenized pool of cultivar "Yuanza9102." Brown lesions were observed in leaves seedling stage to maturity. Using MutMap together with bulked segregation RNA analysis approaches, G-to-A point mutation was exon region candidate gene Arahy.R60CUW, which homolog AtNPR3...
Abstract MDN1/Rea1, as an AAA-type ATPase, is predicted to be the largest protein involved in pre-ribosome maturation most organisms. However, its function plant growth and development poorly understood. Here, we characterized a novel Arabidopsis mutant, dwarf & short root (dsr ) 1 , which shows pleiotropic developmental phenotypes, such slow germination, root, shoot, reduced seed set under normal conditions. Using positional cloning, revealed that AtMDN1 impaired by ‘glutamic acid’...
Abstract In plant chloroplasts, certain ribosomal proteins (RPs) and ribosome biogenesis factors (RBFs) are present in nucleoids, implying an association between nucleoids biogenesis. Arabidopsis, the YqeH-type GTPase Brassinazole-Insensitive Pale Green2 (BPG2) is a chloroplast nucleoid-associated RBF. Here, we investigated relationship BPG2-involved steps by exploring how BPG2 targets ribosomes. Our findings demonstrate that interacts with essential plastid RP, uS10c, RNA (rRNA)-independent...
Seed germination and formation are the beginning ending, respectively, of a plant life cycle. These two processes under fine regulation by internal genetic information. Previously, we demonstrated that Arabidopsis MIDASIN 1 (MDN1) is required for ribosome biogenesis, its dysfunction leads to pleiotropic developmental phenotypes, including impaired embryogenesis slow seed germination. In this study, further found weak mutant MDN1, mdn1-1, exhibits an increased size phenotype. proteomic...
Abstract Ribosomes are required for plant growth and development, ribosome biogenesis-deficient mutants generally display auxin-related phenotypes. Although the relationship between dysfunction auxin is known, many aspects of this subject remain to be understood. We previously reported that MIDASIN 1 (MDN1) an essential pre-60S biogenesis factor (RBF) in Arabidopsis. In study, we further characterized aberrant phenotypes mdn1-1, a weak mutant allele MDN1. Auxin response disturbed both shoots...
Previous studies have suggested that the plastid translation elongation factor, factor thermo unstable (EF-Tu), encoded by RAB GTPASE HOMOLOG 8D (RAB8D) is essential for plant growth. Here, through analyzing root phenotypes of two knock-down alleles RAB8D (rab8d-1 and rab8d-2), we further revealed a vital role in primary development maintenance both stem cell niche (SCN) meristem. Our results showed deficiency affects auxin response SCN signaling. interacts with GENOMES UNCOUPLED 1 (GUN1)...
Abstract Background Some driver oncogenes are still unknown in non-small-cell lung cancer (NSCLC). DNAJC19, a major component of the translocation machinery mitochondrial membranes, is disease-associated protein. Herein, we report role DNAJC19 NSCLC cell growth and metastasis. Methods Immunohistochemistry (IHC) was performed to investigate expression clinical samples. For knockdown or overexpression assays A549 NCI-H1299 cells, lentiviral vectors were used. After assessment functions,...
Ribosome biogenesis is tightly associated with plant growth and reproduction. Mutations in genes encoding ribosomal proteins (RPs) or ribosome factors (RBFs) generally result retarded delayed flowering. However, the early-flowering phenotype resulting from defect rarely reported. We previously identified that AAA-ATPase MIDASIN 1 (MDN1) functions as a 60S RBF Arabidopsis. Here, we found its weak mutant mdn1-1 early-flowering. Transcriptomic analysis showed expression of FLOWERING LOCUS C...
Non-point source pollution from agriculture is a major cause of water quality problems, above all, nutrients such as Nitrogen (N) and Phosphorus (P) various land-use become the leading factors on lake eutrophication. The Poyang Lake biggest fresh in China, which has principal ecological function for Yangtze River. With dramatically developing watershed, degraded eutrophication been increasing. Based data national agricultural census provincial monitoring 2007, load N P at watershed scale...