A5102003432- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Erythrocyte Function and Pathophysiology
- PARP inhibition in cancer therapy
- Virology and Viral Diseases
- Plant Molecular Biology Research
- Chromatin Remodeling and Cancer
- Mercury impact and mitigation studies
- RNA regulation and disease
- Light effects on plants
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- Barrier Structure and Function Studies
- Viral Infections and Vectors
- Axon Guidance and Neuronal Signaling
- Circadian rhythm and melatonin
- Angiogenesis and VEGF in Cancer
- Signaling Pathways in Disease
McGill University
2023-2025
Criminal Investigation Police University of China
2024
Northern Jiangsu People's Hospital
2024
Jiangsu University
2022-2024
McGill University Health Centre
2024
Chongqing Medical University
2024
Affiliated Hospital of Jiangsu University
2022-2024
Tsinghua University
2015-2024
Shandong Provincial Institute of Dermatology and Venereology
2024
Shandong University of Traditional Chinese Medicine
2024
Rett syndrome (RTT) is an autism spectrum developmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Excellent RTT mouse models have been created to study disease mechanisms, leading many important findings with potential therapeutic implications. These include identification of MeCP2 target genes, better understanding neurobiological consequences loss- or mis-function MeCP2, and drug testing mice clinical trials human patients. However, because...
The disease mechanism of Rett syndrome (RTT) is not well understood. Studies in RTT mouse models have suggested a non-cell-autonomous role for astrocytes pathogenesis. However, it clear whether this also true human astrocytes. To establish an vitro model, we previously generated isogenic induced pluripotent stem cell (iPSC) lines from several patients carrying different disease-causing mutations. Here, show that these iPSC can be efficiently differentiated into astroglial progenitors and...
OLIG2 is a transcription factor that activates the expression of myelin-associated genes in oligodendrocyte-lineage cells. However, mechanisms myelin gene inactivation are unclear. Here, we uncover non-canonical function transcriptional repression to modulate myelinogenesis by functionally interacting with tri-methyltransferase SETDB1. Immunoprecipitation and chromatin-immunoprecipitation assays show recruits SETDB1 for H3K9me3 modification on Sox11 gene, which leads inhibition during...
Rett syndrome (RTT), caused by mutations in the methyl-CpG binding protein 2 gene (MECP2), is a debilitating autism spectrum developmental disorder predominantly affecting females. Mecp2 mutant mice have reduced levels of brain-derived neurotrophic factor (BDNF) brain; conditional deletion and overexpression BDNF brain accelerates slows, respectively, disease progression mice. Thus we tested hypothesis that 7,8-dihydroxyflavone (7,8-DHF), small molecule reported to activate high affinity...
Mesenchymal stem cells (MSCs) are considered to be a potential therapeutic tool for liver fibrosis. Inhibiting the activation of hepatic stellate (HSCs) and protecting hepatocytes important mechanisms anti-fibrotic effect MSCs. However, how MSCs inhibit fibrosis by regulating expression microRNAs (miRNAs) has not been fully clarified.Transforming growth factor-β1 (TGF-β1)-activated HSCs LX-2 were single cultured or co-cultured with human umbilical cord mesenchymal (HUC-MSCs). High-throughput...
MeCP2 (methyl CpG binding protein 2) is a key player in recognizing methylated DNA and interpreting the epigenetic information encoded different methylation patterns. The functional significance of to mammalian nervous system highlighted by discovery that mutations MECP2 gene cause Rett syndrome (RTT), devastating neurological disease shares many features with autism. Synaptic scaling form non-Hebbian homeostatic plasticity allows neurons regulate overall excitability response changes...
In both the embryonic and adult brain, a critical step in neurogenesis is neuronal maturation. Deficiency of MeCP2 leads to Rett syndrome, severe neurodevelopmental disorder. We have previously shown that plays roles maturation new neurons during neurogenesis. known regulate expression brain-derived neurotrophic factor (BDNF), potent for Nevertheless, how regulates BDNF deficiency reduced remain unclear. Here, we show microRNA, miR-15a. find miR-15a significant role regulation Overexpression...
Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, molecular function MeCP2 is not fully understood. Here we report systematic identification MeCP2-interacting proteins mouse brain. In addition to transcription regulators, found physically interacts with several modulators RNA splicing, including LEDGF and DHX9. These interactions are disrupted by RTT causing mutations, suggesting they...
The ChIP-seq technique enables genome-wide mapping of in vivo protein-DNA interactions and chromatin states. Current analytical approaches for analysis are largely geared towards single-sample investigations, have limited applicability comparative settings that aim to identify combinatorial patterns enrichment across multiple datasets. We describe a novel probabilistic method, jMOSAiCS, jointly analyzing demonstrate its usefulness with wide range data-driven computational experiments case...
The involvement of immune cells in colorectal cancer (CRC) and their interplay with metabolic disorders are yet to be fully elucidated. This study examines how peripheral cells, inferred genetically, affect CRC investigates the intermediary roles metabolites.
Neutrophil-to-lymphocyte ratio (NLR) is used in the prognostication of multiple malignancies. However, NLR value glioblastoma (GBM) controversial. This controversy may be due to unaccounted effect dexamethasone on NLR. Using retrospective data from 230 isocitrate dehydrogenase-1 (IDH) wild-type GBM patients, we studied prognostic relation treatment GBM. We retrospectively analyzed patients with and use were as dichotomous variables cutoff values 9.5 8 mg, respectively. Correlations between...
Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) the most abundant non-myocyte in adult mouse heart. Simvastatin, a strong inducer Krüppel-like Factor 2 (Klf2) ECs, ameliorates pressure overload induced maladaptive dysfunction. This study aims explore detailed molecular mechanisms anti-remodeling effects simvastatin. Methods Results: RGD-magnetic-nanoparticles were used...