A5048795213- HIV Research and Treatment
- Glycosylation and Glycoproteins Research
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Insect symbiosis and bacterial influences
- RNA and protein synthesis mechanisms
Scripps Research Institute
2019
Howard Hughes Medical Institute
2019
University of California, San Diego
2019
Children’s Institute
2019
Abstract The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies exceptional breadth. MPER usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some polyreactive, such 4E10. Here we describe an broadly antibody major IgG1 PGZL1, which shares V/D-region genes with 4E10, has a shorter CDRH3, is less polyreactive. A recombinant sublineage variant...