A5065901019- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Glycosylation and Glycoproteins Research
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Multiple Sclerosis Research Studies
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Esophageal and GI Pathology
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
Beijing Ditan Hospital
2016-2025
Capital Medical University
2011-2025
Infinitus (China)
2024
Second Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Shanghai Sixth People's Hospital
2019-2023
Shanghai Jiao Tong University
2023
Capital University
2021
Zhuhai People's Hospital
2020
First Affiliated Hospital of Anhui Medical University
2020
It is well known that high lipid and energy diet harmful to health. But the different effects of composed either saturated fatty acids or unsaturated have not been distinguished.Eighteen pregnant C57BL/6j (22-25g) mice were randomly divided into three groups six each fed with chow flaxseed oil (chow 84%, cholesterol 0.2%, 15.8%) lard fat 15.8%). After weaning, offspring same as their mothers during experiment, spatial memory learning ability evaluated by Morris water maze when they 8 weeks...
β-amyloid 1-42 (Aβ1-42)-induced learning and memory impairment in rats is believed to be associated with inflammation. Cytokine production a key pathologic event the progression of inflammatory processes. In this rat study, soybean isoflavones (SIF) was used investigate it's protective effects on inflammation caused by (Aβ1-42), which Alzheimer disease. We characterized ability. cytokine profiles circulating interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) serum expression Toll like...
Abstract The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies exceptional breadth. MPER usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some polyreactive, such 4E10. Here we describe an broadly antibody major IgG1 PGZL1, which shares V/D-region genes with 4E10, has a shorter CDRH3, is less polyreactive. A recombinant sublineage variant...
Background: The EGF domain-specific O-GlcNAc transferase (EOGT), a migrasome marker, plays emerging roles in cancer biology through O-GlcNAcylation modifications, yet its pan-cancer functions and therapeutic implications remain underexplored. This study aimed to systematically characterize EOGT’s oncogenic mechanisms across malignancies, with particular focus on hepatocellular carcinoma (HCC) progression sorafenib resistance. Methods: Multi-omics analysis integrated TCGA/GTEx data from 33...
Diammonium glycyrrhizinate (DG) is a replacement for glycyrrhizic acid, which used as hepatic protector in clinical practice most liver diseases. The potential role of immune response during autoimmune hepatitis-induced by concanavalin A (Con A)-remains to be elucidated.C57BL/6J mice were treated with two different doses DG (75 and 200 mg/kg) 2 hrs before administering Con A. sacrificed after 0, 6, 24 hrs. Liver damage grade serum alanine aminotransferase (ALT), aspartate (AST) total...
Post-translational modifications such as glycosylation play an important role in the function of homeostatic proteins, and are critical driving factors several diseases; however, autoimmune hepatitis is poorly understood. Here, we established O-GlcNAc glycosylation-deficient rat model by knocking out Eogt gene with TALEN-mediated targeting. The deficiency clearly aggravated liver injury concanavalin-A induced hepatitis, delayed self-recovery liver. Moreover, flow cytometry analysis...
Background The neutrophil–lymphocyte ratio (NLR) is a new prognostic predictor for patients with liver cancer. association of NLR and T lymphocytes the pathogenesis progression cancer poorly understood. Methods Seventy-three hepatitis B virus (HBV)-associated primary (HBV-PLC), 50 HBV-associated cirrhosis (HBV-LC) 37 chronic HBV infection (CHB) were prospectively enrolled from July 1, 2013 to February 28, 2014 in Beijing Ditan Hospital, Capital Medical University (Beijing, China). NLR,...
A preliminary study by our group revealed that the deficiency of EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) impaired regulatory T-cell differentiation in autoimmune hepatitis. Nevertheless, prognostic value EOGT advanced hepatocellular carcinoma (HCC) and its relationship with immune infiltration remain obscured. Initially, expression was evaluated Oncomine, TIMER, GEO, UALCAN databases. Besides, potential analyzed using GEPIA, Kaplan-Meier plotter, CPTAC, Cox...
Sepsis is a dangerous disease that caused by an overreaction of the body's immune system to infection and gradually spreads throughout body. This experiment was carried out explore expression LncRNA MEG3 in sepsis its effect on LPS-induced macrophage function. Methods 60 patients admitted our hospital from February 2017 September 2018 were selected as group, 50 non-septic diagnosed treated during same period control group. qRT-PCR used detect level MEG3. ROC curve analyze diagnostic value...
Journal Article Diagnostic accuracy of anti-alpha-fodrin antibodies for primary Sjögren's syndrome Get access Qin Qin, Department Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, P. R. China Search other works by this author on: Oxford Academic Google Scholar Hui Wang, Wang Huai-Zhou Yuan-Lan Huang, Huang ChinaDepartment Changzheng P.R. Hu Li, Li Wei-Wei Zhang, Zhang Jian-Rong Ling-Ling He, He Rheumatology and Immunology, Rong Xia, Xia Transfusion,...
The predictors for gastroesophageal varices (GOV) and hemorrhage development have not been well studied in different liver diseases or population. This study aimed to evaluate whether a new algorithm focusing on chronic hepatitis B (CHB) patients is also applicable other (CLDs) Chinese population.We retrospectively analyzed 659 CHB 386 with CLDs. A total of 439 were included training set, the 220 CLDs validation set. diagnosing GOV was established its sensitivity specificity predicting...
<b><i>Introduction:</i></b> The Omicron variant of the novel coronavirus (COVID-19) has been spreading more rapidly and is infectious, posing a higher risk death treatment difficulty for patients undergoing hemodialysis. This study aims to explore severity rate factors hemodialysis infected with conduct preliminary analysis clinical efficacy drugs. <b><i>Methods:</i></b> Clinical biochemical indicators 219 were statistically analyzed. divided...
Abstract Background Post-operative recurrence rates are high for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). This study aimed to explore the factors associated with post-operative 1-year rate in patients HBV-related HCC who had a single small primary tumor (≤3 cm diameter). Methods was retrospective of 203 (training cohort) and 64 (validation newly diagnosed tumor. The first year follow-up examined. Factors potentially were identified using Cox regression analyses. A...