A5103280907- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Organ Transplantation Techniques and Outcomes
- T-cell and B-cell Immunology
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Liver Diseases and Immunity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and disorders
- Digestive system and related health
- Galectins and Cancer Biology
Capital Medical University
2018-2024
Beijing Tongren Hospital
2024
Beijing Ditan Hospital
2018-2023
Peking University
2019-2020
Diammonium glycyrrhizinate (DG) is a replacement for glycyrrhizic acid, which used as hepatic protector in clinical practice most liver diseases. The potential role of immune response during autoimmune hepatitis-induced by concanavalin A (Con A)-remains to be elucidated.C57BL/6J mice were treated with two different doses DG (75 and 200 mg/kg) 2 hrs before administering Con A. sacrificed after 0, 6, 24 hrs. Liver damage grade serum alanine aminotransferase (ALT), aspartate (AST) total...
Post-translational modifications such as glycosylation play an important role in the function of homeostatic proteins, and are critical driving factors several diseases; however, autoimmune hepatitis is poorly understood. Here, we established O-GlcNAc glycosylation-deficient rat model by knocking out Eogt gene with TALEN-mediated targeting. The deficiency clearly aggravated liver injury concanavalin-A induced hepatitis, delayed self-recovery liver. Moreover, flow cytometry analysis...
A preliminary study by our group revealed that the deficiency of EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) impaired regulatory T-cell differentiation in autoimmune hepatitis. Nevertheless, prognostic value EOGT advanced hepatocellular carcinoma (HCC) and its relationship with immune infiltration remain obscured. Initially, expression was evaluated Oncomine, TIMER, GEO, UALCAN databases. Besides, potential analyzed using GEPIA, Kaplan-Meier plotter, CPTAC, Cox...
Collagen β(1-O) galactosyltransferase 25 domain 1 (GLT25D1) is associated with collagen production and glycosylation, its knockout in mice results embryonic death. However, role liver fibrosis remains elusive, particularly hepatic stellate cells (HSCs), the primary collagen-producing fibrogenesis. Herein, we aimed to elucidate of GLT25D1 HSCs.Bile duct ligation (BDL)-induced mouse models, HSCs (mHSCs), transforming growth factor beta (TGF-β1)-stimulated LX-2 human were used vivo vitro...
Introduction The function of the C6orf120 gene, which encodes an N-glycosylated protein, remains unknown. study was performed to characterize utility gene in carbon tetrachloride-induced acute liver injury and elucidate potential underlying mechanisms by establishing a gene-knockout (C6orf120<sup>–/–</sup>) rat model. Material methods C6orf120<sup>-/-</sup> wild-type (WT) rats were intraperitoneally administered with CCl<sub>4</sub> (1 : 1 v/v olive oil, 2...
To develop a signature based on anoikis-related genes (ARGs) for predicting the prognosis of patients with hepatocellular carcinoma (HCC), and to elucidate molecular mechanisms involved. In this study, bioinformatic algorithms were applied integrate analyze 777 HCC RNA-seq samples from cancer genome atlas international consortium repositories. A prognostic was developed via least absolute shrinkage selection operator-cox regression method. evaluate accuracy in events, multi-type technical...