A5050005218- Sphingolipid Metabolism and Signaling
- Signaling Pathways in Disease
- Connective Tissue Growth Factor Research
- Polymer composites and self-healing
- Cardiac Fibrosis and Remodeling
- Lymphatic System and Diseases
- Liver physiology and pathology
- Cardiovascular Function and Risk Factors
- ATP Synthase and ATPases Research
- Biomarkers in Disease Mechanisms
- Fibroblast Growth Factor Research
- Epoxy Resin Curing Processes
- Hippo pathway signaling and YAP/TAZ
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Health and Disease Prevention
- Inflammasome and immune disorders
- Photopolymerization techniques and applications
- Endoplasmic Reticulum Stress and Disease
- Angiogenesis and VEGF in Cancer
- Healthcare Systems and Public Health
Shanghai East Hospital
2020-2025
State Key Laboratory of Cardiovascular Disease
2024-2025
Henan University of Engineering
2024
Tongji University
2020-2023
Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects CCN5 on neointimal formation and its role preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Stent-implanted porcine artery RNA-seq mouse injury-induced femoral neointima single-cell RNA sequencing were performed. Plasma levels measured by enzyme-linked immunosorbent assay. Endothelial cell (EC)- smooth...
Aims: It is important to understand the mechanism that regulates post-ischemic angiogenesis and explore a new therapeutic target for an effective improvement of revascularization in peripheral artery disease (PAD) patients.Post-ischemic highly orchestrated process, which involves vascular endothelial cells (ECs) proliferation, migration assembly into capillaries.We found significant reduction S1pr2 (sphingosine 1-phosphate receptor 2) after hindlimb ischemia (HLI).We thus hypothesized...
Sphingosine 1-phosphate (S1P), a bioactive lipid molecule, exerts multifaceted effects on cardiovascular functions via S1P receptors, but its cardiac I/R injury are not fully understood. Plasma lipidomics analysis by mass spectrometry revealed that sphingosine lipids, including were significantly down-regulated following in mice. The reduced levels also observed the plasma of coronary heart disease (CHD) patients after percutaneous intervention (PCI) compared with those without PCI. We found...
Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) the most abundant non-myocyte in adult mouse heart. Simvastatin, a strong inducer Krüppel-like Factor 2 (Klf2) ECs, ameliorates pressure overload induced maladaptive dysfunction. This study aims explore detailed molecular mechanisms anti-remodeling effects simvastatin. Methods Results: RGD-magnetic-nanoparticles were used...
Abstract The hepatic vascular niche plays an important role in the pathological process of liver fibrosis. Liver sinusoidal endothelial cells (LSECs) predominantly compose niches. Endothelial cell (EC)‐expressing sphingosine 1‐phosphate receptor 2 (S1pr2) essential regulation functions. Nevertheless, it remains unknown whether LSEC‐S1pr2 might modulate In this study, fibrosis was induced by hepatotoxin carbon tetrachloride (CCl 4 ). expression S1pr2 is significantly downregulated after CCl...
Lymphatic endothelial cell homeostasis plays important roles in normal physiological cardiac functions, and its dysfunction significantly influences pathological remodeling after myocardial infarction (MI). Our results revealed that sphingosine 1-phosphate receptor 1 (S1pr1) expression lymphatic cells (LECs) was sharply changed MI. It has been shown S1pr1 tightly controlled LEC functions homeostasis. We thus hypothesized might be involved post-MI remodeling. generated LEC-conditional...
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Aims: Lower vertebrates and some neonatal mammals are known to possess the ability regenerate cardiomyocyte fully recover after heart injuries within a limited period. Understanding molecular mechanisms of regeneration exploring new ways enhance cardiac hold significant promise for therapeutic intervention failure. Sphingosine 1-phospahte receptor 1 (S1PR1) is highly expressed in cardiomyocytes plays crucial role development pathological remodeling. However, effect cardiomyocyte-expressing...