A5101715455- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Metastasis and carcinoma case studies
- Anesthesia and Neurotoxicity Research
- Gastric Cancer Management and Outcomes
- Transplantation: Methods and Outcomes
- Gastrointestinal motility and disorders
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects of Natural Compounds
- PARP inhibition in cancer therapy
- Drug-Induced Hepatotoxicity and Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Medical and Biological Ozone Research
- Mesenchymal stem cell research
- RNA modifications and cancer
- Hemoglobin structure and function
- ATP Synthase and ATPases Research
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
Jiangsu University
2008-2024
Affiliated Hospital of Jiangsu University
2008-2024
Fudan University
2010-2018
Huashan Hospital
2010-2018
Zhangzhou Municipal Hospital of Fujian Province
2016
Jiangsu Province Hospital
2006
Nanjing Medical University
2006
Mesenchymal stem cells (MSCs) are considered to be a potential therapeutic tool for liver fibrosis. Inhibiting the activation of hepatic stellate (HSCs) and protecting hepatocytes important mechanisms anti-fibrotic effect MSCs. However, how MSCs inhibit fibrosis by regulating expression microRNAs (miRNAs) has not been fully clarified.Transforming growth factor-β1 (TGF-β1)-activated HSCs LX-2 were single cultured or co-cultured with human umbilical cord mesenchymal (HUC-MSCs). High-throughput...
This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti-PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) S-1 oxaliplatin (SOX) (SOXRC), high-dose SOX (SOXR), alone for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
Abstract Nuclear factor of activated T cells ( NFAT ) is a family transcription factors that have important functions in many tumors. However, the expression level and functional role hepatocellular carcinoma HCC remain unclear. In this study, we showed c1 was decreased both tissues cell lines. Low correlated with larger tumor size, advanced tumor‐node‐metastasis TNM stage, high serum AFP level, liver cirrhosis. Furthermore, patients low exhibited poor prognosis. Ectopic inhibited...
Mesenchymal stem cells (MSCs) were shown to have potential therapeutic effects for treatment of liver fibrosis, and dysregulated expression microRNAs (miRNAs) played a pivotal role in the pathogenesis fibrosis by regulating their downstream target genes. However, mechanism which MSCs affect progression miRNA remains unclear. Here, we investigated whether human umbilical cord (HUC-MSCs) attenuated hepatic miR-455-3p its gene. Significantly upregulated (miR-455-3p) was screened out GEO...
Background: Postoperative neurocognitive dysfunction induced by anesthetics, particularly in elderly patients with impaired oxygenation, is a common complication of surgery and eliciting increased interest clinical practice. To investigate the effects anesthetics on neurocognition, we compared propofol versus sevoflurane cerebral oxygenation cognitive outcome undergoing general anesthesia. Methods: Sixty-three (jugular venous bulb oxygen saturation [SjvO 2 ] <50%) or blood flow/cerebral...
Regulatory T cells (Tregs) are critical for maintaining self-tolerance and homeostasis, have potential application in clinical disease therapy, such as autoimmune diseases transplant rejection, but their numbers limited. FOXP3 is a key transcription factor controlling Tregs development function. Although transfection of CD4(+)CD25(-) lymphocytes with the gene can convert them to Treg-like cells, there risk insertional mutagenesis thus an alternative genetic intervention sought. The protein...
COTE1 was recently described as an oncogene in hepatocellular carcinoma and gastric cancer. However, the roles of intrahepatic cholangiocarcinoma (ICC) are little known. Our study is aimed at clarifying novel functions ICC progression, including proliferation, invasion, autophagy. By using quantitative real-time PCR, immunohistochemistry staining, western blotting, we found that expression frequently upregulated tissues, compared to paracarcinoma tissues. High significantly correlated with...
Functional constipation and functional defecation disorders are common types of gastrointestinal disorders.However, it still deserves further discussion on the definition classification both disorders, in spite existence Rome Ⅲ domestic guidelines diagnosis treatment chronic (2013, Wuhan). The main physiological disorder is prolongation conlonic transit time (CTT), while so called outlet obstruction, lies abnormality rectoanal reflex.So suggested to classify obstruction into term evacuation...
Functional gastrointestinal disorders (FGIDs), the most common diseases in gastroenterology, are recognized by morphologic and physiological abnormalities which often occur combination including motility disturbance, increased vagal excitability, altered mucosal immune function, gut microbiota, central nervous system processing.Research on these gut-brain interaction is based using specific diagnostic criteria.The Rome Foundation has played a pivotal role creating criteria, thus new...
Objective To establish a stable transplantation tolerance model by combined treatment with PTD-mFoxp3 fusion protein and allogeneic bone marrow study its application to reduce the incidence of graft-versus-host disease (GVHD).Method BALB/c mice as recipients were randomly divided into four groups,accepted medical linear accelerator ray 3.0-Gy total body irradiation (TBI) before (BMT),and injected donor C57BL/6 cells 3 × 107withinn 4-6 h.The in group A given through tail vein intermittently...
Objective To evaluate the efficacy and toxicity of docetaxel combined with Cisplatin(DDP) 5-fluorouracil(5-Fu) in treatment advanced gastric cancer. Methods 35 patients cancer,which were confirmed by pathological diagnosis,were treated + DDP +5-Fu regimen:docetaxel 70 mg/m2 iv infusion for 4 hours on day 1, 20 1 to 5,5-Fu 750 6 5 every 3 ～ 4weeks. Patients responsing chemotherapy finished at least cycles or proceeded therapy until progression disease (PD). Results 32 cases (91.4% ) available...
Abdominal bloating is a common symptom in patients with functional gastrointestinal diseases (FGIDs). has many features such as conceptual ambiguity, fuzzy diagnosis, high incidence and difficulty treatment. In current clinical practice, early satiety often used an indicator of abdominal bloating. Rome III diagnostic criteria, belongs to dyspepsia (FD) gastroduodenal diseases. According the literature, onset FD closely related gastric sensory disorders motility disorders. fact, existing...