A5100369864- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Cell Adhesion Molecules Research
- Enhanced Recovery After Surgery
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
Ruijin Hospital
2014-2024
Shanghai Jiao Tong University
2014-2024
Zhejiang University
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
Shanghai East Hospital
2024
Shanghai Sixth People's Hospital
2022-2023
First Hospital of Jilin University
2022
Jilin University
2022
Peking University
2022
Peking University Third Hospital
2022
Gastric cancer (GC) has a clear predilection for metastasis toward the omentum which is primarily composed of adipose tissue, indicating that fatty acids may contribute to this phenomenon. However their function remains poorly understood in GC. In study, we investigated role palmitate acid (PA) and its cellular receptor CD36 progression GC.Immunohistochemical (IHC) staining was performed detect expression GC tissues clinical significance determined statistically. over-expression knock-down...
As the predominant immunosuppressive component within tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) inhibit Natural Killer cell (NK cell) activity to promote progression and immune escape; however, mechanisms of cross-talk between CAFs NK cells in gastric cancer (GC) remain poorly understood. In this study, we demonstrate that levels are inversely correlated with abundance human GC. impair anti-tumor capacity by inducing ferroptosis, a death process characterized...
Gastric cancer (GC) is one of the most malignant tumors and second leading cause cancer-related deaths in world. Luteolin, a flavonoid present many fruits green plants, suppresses progression. The effects luteolin on GC cells their underlying mechanisms remain unclear.Effects cell proliferation, migration, invasion, apoptosis were examined vitro vivo by counting kit-8 (CCK-8), transwell assays, flow cytometry, respectively. Real-time reverse transcription polymerase chain reaction (RT-PCR)...
Abstract Neoadjuvant chemotherapy with docetaxel, oxaliplatin, fluorouracil, and leucovorin (FLOT regimen) has shown promising results in terms of pathological response survival rate patients locally advanced resectable gastric cancer (LAGC). However, tegafur gimeracil oteracil potassium capsule (S-1) plus oxaliplatin (SOX is the preferred regimen Eastern countries. Here, we conduct an open label, two-arm, phase II randomized interventional clinical trial (Dragon III; ClinicalTrials.gov:...
The mechanical microenvironment regulated by cancer-associated fibroblasts (CAFs) influence tumor progression. Chemotherapeutic interventions including 5-Fluorouracil (5-Fu) are commonly used for primary treatment of patients with advanced gastric cancer (GC), and the development acquired resistance to 5-Fu limits clinical efficacy these chemotherapies. However, if how interplay between CAFs regulates GC response is poorly understood. In this study, we demonstrate that high-level expression...
<i>Background:</i> Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not biological behavior. This study compared the clinicopathological features prognosis of advanced SRC with non-signet adenocarcinoma (NSRC) stomach. <i>Methods:</i> We reviewed records 4,759 consecutive patients diagnosed gastric who were resected surgically from 1987 to 2003. Of these, 662 (13.9%) had 4,097 NSRC. <i>Results:</i>...
Abstract Background Tumor‐associated miRNAs have been detected in serum or plasma. We investigated whether plasma miRNA‐199a‐3p could be a potential circulating biomarker for early gastric cancer (EGC). Methods By using real‐time qRT‐PCR, the expression of were compared between these pre‐operative plasmas from 30 EGC patients and 70 healthy controls, post‐operative plasmas. Further validation was on an independent set 50 patients. Results The (47.5 ± 6.5) significantly higher than that...
Elevated MELK expression is featured in multiple tumors and correlated with tumorigenesis tumor development. This study aimed to investigate the mechanisms of MELK-mediated development gastric cancer. levels human cancer were determined by quantitative-PCR immunohistochemistry. The effect on cell activity was explored knockdown overexpression experiments. Cell growth measured using CCK-8 assay. Apoptosis cycle distributions analyzed flow cytometry. Migration invasion tested a transwell...
The evidence of combining neoadjuvant chemotherapy with targeted therapy for patients locally advanced gastric cancer is inadequate. We conducted a single-arm phase II trial to evaluate the efficacy and safety S-1, oxaliplatin apatinib (SOXA) in adenocarcinoma.Treatment-naïve received three preoperative cycles S-1 (80-120 mg/day on days 1-14) (130 mg/m2 day 1) two (500 21 days) at 3-week intervals, followed by surgery. primary end-point was pathologic response rate (pRR). This registered...
<i>Background:</i> The purpose of this study was to clarify the clinical significance macroscopic Borrmann type in advanced gastric cancer. <i>Methods:</i> From 1987 2001, we retrospectively studied clinicopathological features and prognoses 3,966 patients with cancer according classification type. <i>Results:</i> Multivariate analysis showed that gender, depth invasion were all associated status nodal involvement. There statistically significant...
// Bao-gui Zhang 1,* ,Tao Du 1,2,* , Ming-de Zang 1 ,Qing Chang Zhi-yuan Fan Jian-fang Li Bei-qin Yu Li-ping Su Chen Chao Yan Qin-long Gu Zheng-gang Zhu Min and Bingya Liu Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, Shanghai, China 2 East Tongji No 150 Jimo Road, * These authors contributed equally to this work Correspondence: Liu, email: Yan, Keywords : Androgen receptor, AKT, MMP9, cancer...
Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy. The EZH2 inhibitor EPZ-6438 was first approved by the US Food and Drug Administration (FDA) 2020. However, its inadequate anti-cancer activity solid tumors limits clinical application. In this study, we utilized multiple cell lines, which are less sensitive to GSK126, combining animal model data investigate underlying mechanism.IncuCyte S3 used explore difference responsiveness hematological...
Zinc-fingers and homeoboxes 1 (ZHX1) was implicated in the carcinogenesis of human cancers. However, little is known about role ZHX1 gastric cancer (GC). Here, we found that downregulated GC tissues compared with paired non-tumor loss expression correlated aggressive clinical characteristics patients. induced G1/S arrest by decreasing cyclin D1 E expression, cell apoptosis Bcl2 downregulation Bax cleaved Caspase-3 upregulation. Our findings revealed could inhibit growth through inducing...
This randomized study aimed to compare the clinical efficacy between novel dual tracer composed of indocyanine green (ICG) and blue dye (BD) conventional radioisotope BD for sentinel lymph node (SLN) mapping in patients with breast cancer.This enrolled 471 clinically node-negative primary cancer. All underwent mastectomy, those undergoing biopsy (SLNB) were receive plus (RB group) or ICG (IB group). The detection performances on SLN identification rate, positive counts, sensitivity,...
This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti-PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) S-1 oxaliplatin (SOX) (SOXRC), high-dose SOX (SOXR), alone for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
To analyze the effects of sevoflurane combined with propofol anesthesia on hemodynamics, stress response, pain, and cognitive function in elderly patients undergoing radical surgery for malignant tumors. A retrospective analysis was performed 100 tumors at our hospital from February 2023 to June 2024. The were divided into two groups based method: control group (n=50, anesthesia) observation anesthesia). Anesthesia parameters, response indicators (norepinephrine, epinephrine, renin),...
The aim of this study was to investigate the effects D2 lymphadenectomy with spleen preservation on surgical outcomes in locally advanced proximal gastric cancer.Between January 2000 and December 2004, a total 366 patients who underwent curative gastrectomy were studied retrospectively from prospectively designed database.The spleen-preservation group experienced shorter operation times, lower incidence perioperative transfusion, postoperative hospital stays. Perioperative transfusion...
Gastric cancer is one of the most common malignancies worldwide. Recent studies have shown that microRNAs play crucial roles in regulating cellular proliferation process gastric cancer. MicroRNA-29c (miR-29c) acts as a tumor suppressor different kinds tumors. Quantitative PCR was performed to evaluate miR-29c expression level 67 patient tissues and 9 cell lines. The effects were explored by assay, soft agar colony formation apoptosis cycle analysis using flow cytometry. target gene predicted...