A5006960063- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Intracranial Aneurysms: Treatment and Complications
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Moyamoya disease diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Hip and Femur Fractures
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Cerebrovascular and Carotid Artery Diseases
- Cancer Cells and Metastasis
- Aortic aneurysm repair treatments
- Glycosylation and Glycoproteins Research
- Chromatin Remodeling and Cancer
- Orthopaedic implants and arthroplasty
- Nanoplatforms for cancer theranostics
- Meningioma and schwannoma management
- Metastasis and carcinoma case studies
- Ferroptosis and cancer prognosis
- Bone fractures and treatments
Shanghai First Maternity and Infant Hospital
2022-2025
Ruijin Hospital
2014-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Sixth People's Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Huashan Hospital
2018-2023
Fudan University
2018-2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2023
Shanghai Clinical Research Center
2021-2023
Capital Medical University
2019-2021
Gastric cancer (GC) has a clear predilection for metastasis toward the omentum which is primarily composed of adipose tissue, indicating that fatty acids may contribute to this phenomenon. However their function remains poorly understood in GC. In study, we investigated role palmitate acid (PA) and its cellular receptor CD36 progression GC.Immunohistochemical (IHC) staining was performed detect expression GC tissues clinical significance determined statistically. over-expression knock-down...
Gastric cancer (GC) is one of the most malignant tumors and second leading cause cancer-related deaths in world. Luteolin, a flavonoid present many fruits green plants, suppresses progression. The effects luteolin on GC cells their underlying mechanisms remain unclear.Effects cell proliferation, migration, invasion, apoptosis were examined vitro vivo by counting kit-8 (CCK-8), transwell assays, flow cytometry, respectively. Real-time reverse transcription polymerase chain reaction (RT-PCR)...
Tumor metastasis is the leading cause of death in patients with advanced gastric cancer (GC). Limited therapeutic regimens are available for this condition, which associated a poor prognosis, and mechanisms underlying tumor remain unclear. In present study, increased histone methyltransferase G9A expression GC tissues correlated stage shorter overall survival, vitro vivo experiments revealed that promoted invasion metastasis. Moreover, we observed Reg IV induced via p-ERK/p-SP1 pathway. SP1...
// Bao-gui Zhang 1,* ,Tao Du 1,2,* , Ming-de Zang 1 ,Qing Chang Zhi-yuan Fan Jian-fang Li Bei-qin Yu Li-ping Su Chen Chao Yan Qin-long Gu Zheng-gang Zhu Min and Bingya Liu Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, Shanghai, China 2 East Tongji No 150 Jimo Road, * These authors contributed equally to this work Correspondence: Liu, email: Yan, Keywords : Androgen receptor, AKT, MMP9, cancer...
// Hexiao Wang 1, * , Lei Hu Mingde Zang 1 Baogui Zhang 2 Yantao Duan Zhiyuan Fan Jianfang Li Liping Su Min Yan Zhenggang Zhu Bingya Liu Qiumeng Yang Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, 200025, People's Republic China Affiliated Hospital Jining Medical University, 272000, These authors have contributed equally to this work Correspondence to: Yang, e-mail: yangqiumeng@hotmail.com Liu,...
Abstract Background Oxidative stress and vascular smooth muscle cell (VSMC) phenotypic modulation influence intracranial aneurysm (IA) formation progression. plays an important role in phenotype switching, nuclear factor erythroid 2-related 2 (Nrf-2) is one of the main antioxidant systems. Unfortunately, little known about how Nrf-2 signaling influences VSMC switches during IA pathogenesis. Methods We examined effect activation on progression elastase-induced rat model. also developed a...
Abstract Background The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a 5′ AMP-activated protein kinase (AMPK) agonist that has protective effect on vasculature. present study investigated whether metformin modulates VSMC switching via AMPK/acetyl-CoA carboxylase (ACC) pathway during IA pathogenesis. Methods Adult male Sprague-Dawley...
Tumor metastasis is a crucial impediment to the treatment of gastric cancer (GC), and epithelial-to-mesenchymal transition (EMT) program plays critical role for initiation GC metastasis. Thus, aim this study investigate regulation lnc-CTSLP4 in EMT process during progression. We found that was significantly downregulated tumor tissues compared with adjacent non-tumor tissues, its levels were closely correlated local invasion, TNM stage, lymph node metastasis, prognosis patients. Loss-...
Abstract Adenosine triphosphate (ATP) in the tumor microenvironment serves a vital role during progression. ATP synthase F1 β subunit (ATP5B) is one of most important subunits and increases cellular levels. ATP5B reportedly participates carcinogenesis several tumors. However, regulatory mechanisms remain poorly understood gastric cancer (GC). Here, we determined that high expression tissues GC positively correlated with age, size, TNM stage, lymph node metastasis, patients’ poor prognosis....
Somatic copy number variations (SCNVs) in the CDKN2A gene are among most frequent events dysplasia-carcinoma sequence of esophageal squamous cell carcinoma. However, whether SCNVs useful biomarkers for risk stratification and management patients with dysplasia (ESCdys) is unknown. This study aimed to investigate characteristics prognostic value mild or moderate (m/M) ESCdys.
Increasing evidence indicates that angiogenesis plays an important role in tumor progression. The function of cathepsin L (CTSL), endosomal proteolytic enzyme, promoting metastasis is well recognized. mechanisms by which CTSL has promoted the gastric cancer (GC), however, remains unclear.The nuclear expression levels were assessed GC samples. effects on determined endothelial tube formation analysis, HUVEC migration assay, and chick embryo chorioallantoic membrane (CAM) assay. involvement...
// Minlu Huang 1 , Xinjie Ma Hongpeng Shi Lei Hu Zhiyuan Fan Li Pang Zhu Xiao Yang Wei Xu Binya Liu Zhenggang and Chen Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, 200025, People’s Republic China Correspondence to: Li, email: leedoctor@sina.com Keywords: FAM83D, gastric cancer, proliferation, HMMR, TPX2 Received: August 17, 2016     Accepted: June 02,...
Cerebral aneurysm growth is characterized by vessel wall frailness, although the underlying cellular mechanisms are unclear. Here, we examined relationship between inflammatory smooth muscle cells (SMCs) and endothelial (ECs) in cerebral aneurysms, including SMC-induced changes ECs. Five saccular aneurysms were collected five temporal artery samples used as controls. Cells cytokines detected immunohistochemistry TUNEL (transferase dUTP nick end labeling) assays performed to evaluate...
Gastric cancer (GC) is one of the most aggressive malignancies and has a poor prognosis. Identifying novel diagnostic prognostic markers great importance for management treatment GC. Long non-coding RNAs (lncRNAs), which are involved in multiple processes during development progression cancer, may act as potential biomarkers Here, by performing data mining using four microarray sets GC downloaded from Gene Expression Omnibus (GEO) database with different classifiers risk score analyses, we...
Abstract Erlotinib, an EGFR tyrosine kinase inhibitor, is used for treating patients with cancer exhibiting overexpression or mutation. However, the response rate of erlotinib low among gastric (GC). The findings this study illustrated that bromodomain PHD finger transcription factor (BPTF) partially responsible resistance in GC, and combination BPTF inhibitor AU‐1 synergistically inhibited tumor growth both vivo vitro. epigenetic function decreased transcriptional activity c‐MYC on PLCG1 by...
Acellular matrix is a type of promising biomaterial for wound healing promotion. Although acellular bovine and porcine tissues have proven effective, religious restrictions risks disease transmission remain barriers to their clinical use. fish skin (AFS), given its similarity human structure without the aforementioned disadvantages, thus seen as an attractive alternative. This study aims fabricate AFS from black carp (Mylopharyngodon piceus), evaluate physical mechanical properties assess...
Abstract Background A understanding of morphological characteristics are important to femoral neck fractures (FNFs) resulting in high rates complications the young and middle-aged adults detailed data is lack literature. We aimed report on relationship between them with (FNFs). Methods The postoperative CT images one hundred fifty-two FNFs were retrospectively reviewed. After image standardization, including fracture orientation, cortex comminution, intraosseous bone defects measured...
Background: Inflammatory cells, such as macrophages, play key roles in the pathogenesis of intracranial aneurysms (IAs). Berberine (BBR), an active component a Chinese herb Coptis chinensis French, has been shown to have anti-inflammatory properties through suppressing macrophage migration various inflammation animal model. The goal this study was examine BBR's effect on and IAs formation rodent aneurysm Methods Results: Human tissues were collected by microsurgical clipping immunostained...