A5100684105- Hip and Femur Fractures
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Pelvic and Acetabular Injuries
- Wound Healing and Treatments
- Spinal Fractures and Fixation Techniques
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Hip disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Bone health and osteoporosis research
- Gallbladder and Bile Duct Disorders
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Wnt/β-catenin signaling in development and cancer
- Thyroid Cancer Diagnosis and Treatment
- Elbow and Forearm Trauma Treatment
- Collagen: Extraction and Characterization
- Pregnancy-related medical research
- Plant Molecular Biology Research
- Hydrogen's biological and therapeutic effects
- Plant Reproductive Biology
- Immune cells in cancer
Chinese PLA General Hospital
2009-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Sixth People's Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Second Affiliated Hospital of Nantong University
2022-2024
Tianjin Medical University
2018-2024
Tianjin Medical University Eye Hospital
2024
Nankai University
2023-2024
Hunan University of Traditional Chinese Medicine
2023-2024
Nantong University
2022-2024
The insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue growth and metabolism multicellular animals. Although core components of the are well defined, less is known about mechanisms that adjust sensitivity to extracellular stimuli. In humans, disturbance insulin leads impaired clearance glucose from blood stream, which hallmark diabetes. Here we present results genetic screen Drosophila designed identify regulators vivo. Components MAPK/ERK were identified...
Osteoporosis is a chronic condition affecting patients' morbidity and mortality represents big socioeconomic burden. Because stem cells can proliferate differentiate into bone-forming cells, cell therapy for osteoporosis has been widely studied. However, as live drug face multiple challenges because of their instability during preservation transportation. In addition, potential adverse effects such embolism, tumorigenicity, immunogenicity.Herein, we sought to use cell-mimicking targeted...
Macrophages play a pivotal role in tumor immunity. We report that reprogramming of macrophages to tumor-associated (TAMs) promotes the secretion exosomes. Mechanistically, increased exosome is driven by MADD, which phosphorylated Akt upon TAM induction and activates Rab27a. exosomes carry high levels programmed death-ligand 1 (PD-L1) potently suppress proliferation function CD8
Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) cascades, it is not known whether they utilize distinct intracellular signaling pathways. In this study, we first examined a variety pharmacological inhibitors on TNF H2O2-induced JNK activation. Gö6983 or staurosporine, which inhibits protein C isoforms had no effects However, Gö6976 calphostin, can inhibit as well D (PKD), blocked H2O2- but TNF-induced activation, suggesting that PKD may...
// Yan Bai 1,* , Yusong Lin 2,* Wei Zhang 3 Lingfei Kong 4 Lifu Wang Panli Zuo 5 Ignacio Vallines 6 Benjamin Schmitt 7 Jie Tian 8 Xiaolei Song 9 Jinyuan Zhou and Meiyun 1 Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial Hospital, Zhengzhou, Henan, China 2 Cooperative Innovation Center Internet Healthcare School Software Applied Technology, University, Ren Ji Shanghai Jiao Tong Shanghai, Pathology, MR Collaborations NE Asia, Siemens China, Beijing, Imaging...
Stimuli-responsive nanoparticles (NPs), so-called "smart" NPs, possess great potentials in drug delivery. Presently, the intelligence of smart NPs is mainly based on their chemical or physical changes to stimuli, which are usually "mechanical" and fundamentally different from biological intelligence. Inspired by mitochondria (MT), a biosmart nanoparticle with microenvironment targeting self-adaptive capacity (MTSNP) was fabricated for ischemic tissue repair. The were designed as...
Abstract Diabetic wounds impose significant burdens on patients' quality of life and healthcare resources due to impaired healing potential. Factors like hyperglycemia, oxidative stress, angiogenesis excessive inflammation contribute the delayed trajectory. Mounting evidence indicates a close association between mitochondrial function diabetic complications, including chronic wounds. Mitochondria are critical for providing energy essential wound processes. However, dysfunction exacerbates...
Rationale: Although a few injectable hydrogels have shown reliable biosafety and moderate promise in treating myocardial infarction (MI), the updated hydrogel systems with an on-demand biodegradation multi-biofunctions to deliver therapeutic drug would achieve more prominent efficacy future applications.In this report, conductive crosslinked by matrix metalloproteinasesensitive peptides (MMP-SP) was rationally constructed stabilize hypoxia-inducible factor-1α (HIF-1α) recover heart functions...
Objective The purpose of this study is to determine the diagnostic value and net clinical benefit interleukin-10 (IL-10), interleukin-17 (IL-17), procalcitonin (PCT), combination tests in patients with sepsis, which will serve as a standard for sepsis early detection. Patients methods An investigation 84 81 local inflammatory diseases admitted ICU Tongji University Hospital 2021. In addition comparing inter-group variability, indicators relevant diagnosis therapy were screened. Results LASSO...
The biomechanical characteristics of midshaft clavicular fractures treated with titanium elastic nail (TEN) is unclear. This study aimed to present a finite element analysis involved in TEN fixation and reconstruction plate for fractures.Finite models the intact clavicle fixed were built. distal displacement, peak stress, stress distribution on 3 calculated under axial compression cantilever bending.In both loading configurations, generated highest displacement clavicle, followed by plate....
Glucocorticoids are the first line of choice in treatment cerebral edema associated with brain tumors. High-dose glucocorticoids reduce extent within hours, often relieving critical increases intracranial pressure, but mechanisms by which modulate water content not well-understood. A possible target action may be glucocorticoid receptor-expressing astrocytes, primary regulators interstitial ion homeostasis brain. In this study, we demonstrate that two glucocorticoids, methylprednisolone and...
Acellular matrix is a type of promising biomaterial for wound healing promotion. Although acellular bovine and porcine tissues have proven effective, religious restrictions risks disease transmission remain barriers to their clinical use. fish skin (AFS), given its similarity human structure without the aforementioned disadvantages, thus seen as an attractive alternative. This study aims fabricate AFS from black carp (Mylopharyngodon piceus), evaluate physical mechanical properties assess...
It is a large clinical challenge to repair critical-size bone defects, and vascularization in the early stage of vital importance regeneration. In recent years, 3D-printed bioceramic kind common bioactive scaffold for repairing defects. However, conventional scaffolds consist stacked solid struts with low porosity, which limits ability angiogenesis The hollow tube structure can induce endothelial cells build vascular system. this study,β-tricalcium phosphate (β-TCP) containing were prepared...