A5100659748- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Healthcare Decision-Making and Restraints
- Drug Transport and Resistance Mechanisms
- Ethics in Clinical Research
- COVID-19 and Mental Health
- Pharmaceutical studies and practices
- Advanced biosensing and bioanalysis techniques
- Pregnancy and preeclampsia studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Mental Health Research Topics
- Glutathione Transferases and Polymorphisms
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Dialysis and Renal Disease Management
- Acute Lymphoblastic Leukemia research
- Identity, Memory, and Therapy
- Antibiotic Resistance in Bacteria
- Treatment of Major Depression
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Pharmacovigilance and Adverse Drug Reactions
- Gout, Hyperuricemia, Uric Acid
Sun Yat-sen University
2024-2025
Guizhou Provincial People's Hospital
2020-2025
Fujian Medical University
2023-2025
Guangxi Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2025
Second Affiliated Hospital of Fujian Medical University
2025
Zhejiang University of Technology
2024
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2012-2024
Shanghai Mental Health Center
2012-2024
Novel gradient bimetallic hydrogel promotes tendon-to-bone interface reconstruction by synchronous regeneration.
Droplet digital PCR (ddPCR) has emerged as a promising tool of pathogen detection in bloodstream infections (BSIs) critical care medicine. However, different ddPCR platforms have variable sensitivity and specificity for diverse microorganisms at various infection sites. There is still lack prospective clinical studies aimed validating interpreting the discrepant results diagnosing BSI intensive unit (ICU) practice.A diagnostic study multiplex panels was conducted general ICU from May 21,...
Idiopathic pulmonary fibrosis (IPF) is a chronic and deadly disease with poor prognosis few treatment options. Pathological remodeling of the extracellular matrix (ECM) by myofibroblasts key factor that drives pathogenesis, although underlying mechanisms remain unknown. Alternative polyadenylation (APA) has recently been shown to play major role in cellular responses stress driving expression fibrotic factors ECMs through altering microRNA sensitivity, but connection IPF not established....
COVID-19 has profoundly affected the work of mental health professionals with many transitioning to telehealth comply public measures. This large international study examined impact pandemic on clinicians' use. survey was conducted professionals, primarily psychiatrists and psychologists, registered WHO's Global Clinical Practice Network (GCPN). 1206 clinicians from 100 countries completed section online in one six languages between June 4 July 7, 2020. Participants were asked about their...
A robust and practical difluoroalkylation synthon, α,α-difluoroenol species, which generated in situ from trifluoromethyl diazo compounds water the presence of dirhodium complex, is disclosed. As compared to presynthesized difluoroenoxysilane formed difluoroenolate under basic conditions, this difluoroenol intermediate displayed versatile reactivity, resulting dramatically improved enantioselectivity mild conditions. demonstrated catalytic asymmetric aldol reaction Mannich reactions with...
Abstract Diabetic wounds impose significant burdens on patients' quality of life and healthcare resources due to impaired healing potential. Factors like hyperglycemia, oxidative stress, angiogenesis excessive inflammation contribute the delayed trajectory. Mounting evidence indicates a close association between mitochondrial function diabetic complications, including chronic wounds. Mitochondria are critical for providing energy essential wound processes. However, dysfunction exacerbates...
The combination of surgical peripheral iridectomy, goniosynechialysis, and goniotomy is a safe effective approach for advanced primary angle closure glaucoma without cataract.
Morchella esculenta is a valuable edible fungus with multidimensional bioactivities; however, research on M. protein and its beneficial effects nonalcoholic fatty liver disease (NAFLD) have been limited.
Given the challenging circumstances of aging with disability, family caregivers (FGs) face significant strain. Resilience, however, is a crucial protective factor against adverse caregiving outcomes. The study thus aimed to determine latent classes resilience among FGs and examine how these are related care burden psychological distress. This was cross-sectional descriptive that included 248 in China. Latent class analysis conducted exhibited by FGs. revealed four distinct resilience: high...
Background Alzheimer’s disease poses a major public health challenge, with aducanumab’s approval in 2021 as the first disease-modifying therapy raising important safety considerations. This study analyzed Food Drug Administration Adverse Event Reporting System (FAERS) database to evaluate real-world profile and identify potential risk factors. Methods We conducted comprehensive pharmacovigilance using FAERS from January 2004 June 2024, analyzing 510 aducanumab-associated reports integrated...
Objective: To assess the impact of employing KHA-200 hemoperfusion device in conjunction with hemodialysis therapy elimination serum solutes among maintenance patients. Methods: A total ninety-two (MHD) patients from our hospital's center were judiciously chosen and allocated randomly into two groups: conventional group, serving as control group utilizing combination hemodialysis, denoted experimental a 1:1 ratio. We compared variations solute indices, including blood urea nitrogen,...
ABSTRACT This study investigated alterations in the skin microclimate of sacrococcygeal compression area patients with malignant head and neck tumours before after surgery. Additionally, it evaluated effect preventive dressings on this their association intraoperative acquired pressure injuries (IAPIs), aiming to provide a foundation for preventing reducing these injuries. Thirty were randomly assigned into control two intervention groups. The group was not protected by dressing....
Importance The safety and effectiveness of combining surgical peripheral iridectomy (SPI) with goniosynechialysis (GSL) goniotomy (GT) vs trabeculectomy for intraocular pressure (IOP) reduction remains unknown. Objective To investigate the at 1 year SPI + GSL GT in advanced primary angle-closure glaucoma (PACG) without cataract. Design, Setting, Participants This noninferiority randomized clinical trial was conducted 8 tertiary eye centers China. A total 88 Chinese patients (88 eyes) PACG...
Middle-aged to elderly patients with type 2 diabetes mellitus (T2DM) exhibit reduced functional connectivity and brain atrophy underlying cognitive decrements; however, little is known about abnormalities in young patients. To detect anatomical changes T2DM during the early disease stage. Case-control study. Tertiary referral hospital. Thirty-five (<40 years of age) no detectable microangiopathy 32 nondiabetic control subjects. None. Subjects underwent neuropsychological assessments...
Abstract Fibrosis of the skin and internal organs is a hallmark systemic sclerosis (SSc). Although pathogenesis SSc poorly understood, increasing evidence suggests that interleukins (IL)‐4 − 13 contribute to fibrosis by promoting collagen production myofibroblast differentiation. Signal transducers activators transcription 6 (STAT6) one most important downstream factors activated both IL‐4 IL‐13. However, it not completely understood whether STAT6 plays role during in SSc. In this study, we...
Background: Subclinical hypothyroidism (SCH) in pregnancy is associated with adverse and perinatal outcomes. However, few studies have investigated the evolution of postpartum thyroid function these women. This study aimed to determine outcomes SCH during clinical biochemical factors related long-term hypothyroidism. Methods: A total 393 women diagnosed (defined as thyrotropin [TSH] >4.0 μIU/mL normal free thyroxine levels according 2017 American Thyroid Association guidelines) were...
Objective: This study aimed to investigate the characteristics and spectrum of cardiotoxicity induced by various antipsychotics based on United States Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. Methods: Data FAERS database from first quarter 2015 fourth 2020 were downloaded for disproportionality analysis. The significant signal was evaluated reporting odds ratios information components with statistical shrinkage transformation. Results: A total 2,361,487...
Quercetin (QUE), a health supplement, can improve renal function in diabetic nephropathy (DN) rats by ameliorating podocyte injury. Its clinical trial for insufficiency advanced diabetes (NCT02848131) is currently underway. This study aimed to investigate the mechanism of QUE protecting against injury attenuate DN through network pharmacology, microarray data analysis, and molecular docking. QUE-associated targets, genes related both DN, were obtained from different comprehensive databases...
Whether elevated triglyceride (TG) levels during pregnancy were a biomarker for postpartum abnormal glucose metabolism (AGM) in women with previous gestational diabetes mellitus (GDM) remained unknown. The aim of this study was to investigate the association between TG second trimester and AGM GDM women. This retrospective cohort including 513 A 75 g oral tolerance test (OGTT) performed, lipid determined period. patients categorized into tertiles according their at 24-28 weeks gestation (TG...
Background: The complication, pulmonary fibrosis (PF) secondary to COVID-19, may have a second wave of late mortality, given the huge number individuals infected by COVID-19. However, molecular mechanisms PF COVID-19 haven't been fully elucidated, making identification novel strategies for targeted therapy challenging. This study aimed systematically identify and high-frequency core traditional Chinese medicine (TCM) targeting through network pharmacology data mining.Methods: were identified...