We report the facile hydrothermal synthesis and surface functionalization of branched polyethyleneimine (PEI)-coated iron oxide nanoparticles (Fe3O4–PEI NPs) for biomedical applications. In this study, Fe3O4–PEI NPs were synthesized via a one-pot method in presence PEI. The formed with primary amine groups on able to be further functionalized polyethylene glycol (PEG), acetic anhydride, succinic respectively. pristine characterized different techniques. showed that sizes controlled by...

We report a facile approach for fabrication of Fe3O4@Au nanocomposite particles (NCPs) as dual mode contrast agent both magnetic resonance (MR) and computed tomography (CT) imaging applications. In this study, Fe3O4 nanoparticles (NPs) prepared by controlled coprecipitation were used core subsequent electrostatic layer-by-layer (LbL) assembly poly(γ-glutamic acid) (PGA) poly(L-lysine) (PLL) to form PGA/PLL/PGA multilayers, followed with dendrimer-entrapped gold NPs (Au DENPs) formed using...

We report a facile approach to synthesizing 3-aminopropyltrimethoxysilane (APTS)-coated magnetic iron oxide (Fe3O4@APTS) nanoparticles (NPs) with tunable surface functional groups for potential biomedical applications. The Fe3O4 NPs mean diameter of 6.5 nm were synthesized by hydrothermal route in the presence APTS. formed amine-surfaced Fe3O4@APTS further chemically modified acetic anhydride and succinic generate neutral (Fe3O4@APTS⋅Ac) negatively charged (Fe3O4@APTS⋅SAH) NPs. These...

A unique dendrimer-assisted approach is reported to create Fe3O4/Au nanocomposite particles (NCPs) for targeted dual mode computed tomography/magnetic resonance (CT/MR) imaging of tumors. In this approach, preformed Fe3O4 nanoparticles (NPs) are assembled with multilayers poly(γ-glutamic acid) (PGA)/poly(l-lysine)/PGA/folic acid (FA)-modified dendrimer-entrapped gold via a layer-by-layer self-assembly technique. The interlayers crosslinked 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide...

We report a facile approach to forming dendrimer-stabilized gold nanoparticles (Au DSNPs) through the use of amine-terminated fifth-generation poly(amidoamine) (PAMAM) dendrimers modified by diatrizoic acid (G5.NH2-DTA) as stabilizers for enhanced computed tomography (CT) imaging applications. In this study, simply mixing G5.NH2-DTA with salt in aqueous solution at room temperature, dendrimer-entrapped DENPs) mean core size 2.5 nm were able be spontaneously formed. Followed an acetylation...

Abstract: Development of dual-mode or multi-mode imaging contrast agents is important for accurate and self-confirmatory diagnosis cancer. We report a new multifunctional, dendrimer-based gold nanoparticle (AuNP) as dual-modality agent magnetic resonance (MR)/computed tomography (CT) breast cancer cells in vitro vivo. In this study, amine-terminated generation 5 poly(amidoamine) dendrimers modified with gadolinium chelate (DOTA-NHS) polyethylene glycol monomethyl ether were used templates to...

Summary We propose a new embedded finite element method to simulate partial differential equations over domains with internal interfaces. Our approach belongs the family of surrogate/approximate interface methods and relies on idea shifting location value jump conditions. This choice has goal preserving optimal convergence rates while avoiding small cut cells related problematic issues, typical traditional methods. The proposed is accurate, robust, efficient, simple implement. apply this...

Abstract Phase‐field methods are attractive for simulating the mechanical failure of geometrically complex porous microstructures described by 2D/3D x‐ray CT images in subsurface (e.g., CO storage) and manufacturing Li‐ion battery) applications. They capture nucleation, growth, branching fractures without prior knowledge propagation path or having to remesh domain. Their drawback lies high computational cost typical domain sizes encountered practice. We present a multiscale preconditioner...

Background Breast MRI is a sensitive imaging technique to assess breast cancer but its effectiveness still remains be improved. Purpose To evaluate the diagnostic performance of diffusion‐weighted (DWI), diffusion kurtosis (DKI), and quantitative dynamic contrast‐enhanced (DCE)‐MRI in differentiating malignant from benign lesions independently or jointly explore whether correlations exist among these parameters. Study Type Retrospective. Population In all, 106 patients with (47 malignant, 59...

Middle-aged to elderly patients with type 2 diabetes mellitus (T2DM) exhibit reduced functional connectivity and brain atrophy underlying cognitive decrements; however, little is known about abnormalities in young patients. To detect anatomical changes T2DM during the early disease stage. Case-control study. Tertiary referral hospital. Thirty-five (<40 years of age) no detectable microangiopathy 32 nondiabetic control subjects. None. Subjects underwent neuropsychological assessments...

Type 2 diabetes mellitus (T2DM) is a serious public health problem, and the phenomenon of T2DM occurring in younger people has directed more attention to functional changes brain. In this study, microstructural integrity white matter (WM) was evaluated three groups middle-aged subjects: healthy controls (HCs) patients with without peripheral microvascular complications (T2DM-C T2DM-NC patients, respectively). Diffusion tensor imaging (DTI) related clinical examinations were performed 66...

Background Breast diffusion kurtosis imaging (DKI) is a novel MRI technique to assess breast cancer but the effectivity still remains be improved. Purpose To investigate performance of whole‐volume histogram parameters derived from DKI model for differentiating benign and malignant lesions. Study Type Retrospective. Population In all, 120 patients with lesions (62 malignant, 58 benign). Sequence sequence seven b‐values (0, 500, 1000, 1500, 2000, 2500, 3000 s/mm 2 ) DWI two (0 1000 on 3.0T...

The rapid rise in Type 2 diabetes mellitus (T2DM) among young adults makes it important to understand structural changes the brain at a presenile stage. This study examined global and regional atrophy middle-aged with T2DM, focus on those without clinical evidence of microvascular complications.The recruited 66 dementia-free subjects (40 26 healthy volunteers [HVs]). Patients were grouped according presence (T2DM-C; n = 20) or absence (T2DM-NC; diabetic complications. Global volume...

To evaluate diagnostic performances of CESM for breast diseases with comparison to MRI in China.Sixty-eight patients 77 lesions underwent MR and CESM. Two radiologists interpreted either or images, separately independently. BI-RADS 1-3 4-5 were classified into the suspicious benign malignant groups. Diagnostic accuracy parameters calculated. Receiver operating characteristic (ROC) curves constructed two modalities. The agreement correlation between maximum lesion diameter based on MRI,...

Purpose To test the following hypotheses in a murine model of pancreatic cancer: (a) Vaccination with antigen-loaded iron-labeled dendritic cells reduces T2-weighted signal intensity at magnetic resonance (MR) imaging within peripheral draining lymph nodes ( LN node s) and (b) such reductions are associated tumor size changes after cell vaccination. Materials Methods The institutional animal care use committee approved this study. Panc02 were implanted into flanks 27 C57BL/6 mice...

Selective laser melted (SLMed) AlSi10Mg alloys usually fail before necking during tensile tests, which results in inadequate ductility. To overcome this problem, here we introduced Al4C3 nanorods into the primary Al cells of SLMed via in-situ chemical reaction. Tensile tests revealed that those in-cell not only increased strain-hardening ability but also delayed fracture beyond necking. Consequently, 15% strength increase and 78% ductility were achieved simultaneously. Post-tensile TEM...

Abstract We propose a simplified version of the Shifted Fracture Method (SFM), which relies on an approximate fracture geometry representation combined with interface conditions. In particular, we show that complexities earlier SFM implementations, associated use mixed variational formulation equilibrium equations, can be avoided. This approach has minimal impact overall accuracy numerical computations but leads to considerable gains in performance. These outcomes justified because proposed...