A5101475006- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Ocular Oncology and Treatments
- Radiology practices and education
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ophthalmology and Visual Impairment Studies
- Traumatic Ocular and Foreign Body Injuries
- Retinal Development and Disorders
- Advanced Drug Delivery Systems
- Innovations in Medical Education
- Wound Healing and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Proteoglycans and glycosaminoglycans research
- Kruppel-like factors research
- Ocular Diseases and Behçet’s Syndrome
- Flavonoids in Medical Research
- Nerve injury and regeneration
Sun Yat-sen University
2016-2025
Zhongshan Ophthalmic Center, Sun Yat-sen University
2019-2022
National Natural Science Foundation of China
2019
Creative Commons
2015
Christie's
2015
Guangdong Provincial Center for Disease Control and Prevention
2015
Coherent (United States)
2015
Zhongshan Hospital of Xiamen University
2009
State Key Laboratory of Ophthalmology
2009
To investigate the effectiveness and safety of phacogoniotomy versus phacotrabeculectomy (PVP) among patients with advanced primary angle-closure glaucoma (PACG) cataracts. Multicenter, randomized controlled, non-inferiority trial. A total 124 (124 eyes) PACG cataracts were enrolled, 65 in group 59 group. Patients followed up for 12 months standardized evaluations. The outcome was reduction intraocular pressure (IOP) from baseline to postoperatively, which a margin 4 mmHg evaluated....
Although diabetic retinopathy (DR) has long been considered as a microvascular disorder, mounting evidence suggests that retinal neurodegeneration, in particular synaptic loss and dysfunction of ganglion cells (RGCs) may precede changes. Key molecules involved this process remain poorly defined. The microtubule-associated protein tau is critical mediator neurotoxicity Alzheimer's disease (AD) other neurodegenerative diseases. However, the effect tau, if any, context diabetes-induced...
Background Posterior capsular opacification (PCO) is a common complication of cataract surgery. Transforming growth factor-β2 (TGF-β2) plays important roles in the development PCO. The existing pharmacological treatments are not satisfactory and can have toxic side effects. Methodologies/Principal Findings We evaluated effect pirfenidone on proliferation, migration epithlial-mesenchymal transition human lens epithelial cell line SRA01/04 (HLECs) vitro. After treatment with 0, 0.25, 0.5 mg/ml...
Précis: 240° and 360° goniotomy (GT) demonstrated similar efficacy in intraocular pressure reduction, both outperforming 120°GT juvenile open-angle glaucoma (JOAG) patients at postoperative 6 months follow-up. Purpose: To compare the surgical safety of 120-, 240-, 360-degree for with (JOAG). Patients Methods: This multicenter retrospective study included 102 eyes JOAG patients, who underwent GT a follow up least months. were categorized into three groups: (1) 120°GT, (2) 240°GT, (3) 360°GT....
The purpose of this study was to determine the influence optic nerve head (ONH) rotation and tilt on structure-function (S-F) relationship differences between early open-angle glaucoma (OAG) with without high myopia (HM). A total 164 eyes, including 69 highly myopic (HMG) 60 OAG 35 healthy HM were included. All eyes underwent spectral-domain optical coherence tomography, standard automated perimetry, fundus photography simultaneously. S-F relationships analyzed by comparing peripapillary...
Primary open angle glaucoma (POAG) is the leading cause of irreversible blindness. Dysfunction trabecular meshwork (TM), resulting in decreased outflow aqueous humor and increased intraocular pressure (IOP), plays an important role pathogenesis POAG. However, underlying mechanisms still remain unclear. In this study, we demonstrated that eIF2-α/ATF4/CHOP branch unfolded protein response (UPR) was activated human cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure. Inhibition ATF4...
Objective Team-based learning (TBL) is an increasingly popular teaching method in medical education. However, TBL hasn't been well-studied the ophthalmology clerkship context. This study was to examine impact of modified such context and assess student evaluations TBL. Methods Ninety-nine students 8-year clinical medicine program from Zhongshan Ophthalmic Centre, Sun Yat-sen University, were randomly divided into four sequential units assigned six teams with same faculty. The one-week module...
Pirfinedone (PFD) is a novel agent which has the potential to prevent scarring in eyes. The 0.5% PFD eye drops exhibits poor bioavailability. Whereas, feasibility of using contact lens as ocular drug delivery device initiated possibilities.To evaluate by soft (SCL) vivo, we screened most suitable material for among various commercially available SCL materials vitro.Firstly, 11 different SCLs (-1.00 diopter) were respectively soaked 2 ml 0.05% PFD-loading solution 24 h fully absorb drug, and...
Few reports described efficient transfection in the trabecular meshwork (TM) vivo. In present study, we investigated distribution of cy3-labeled siRNAs after giving injection into anterior chamber (AC) and explored use RhoA siRNA (siRhoA) to modulate intraocular pressure (IOP) through downregulation gene protein expression. Cy3-labeled were injected AC investigate distribution. addition, siRhoA was applied normal DEX-induced elevated IOP mice. The detected at 1d post-injection (PI) using...
The aim of this study was to investigate the safety and efficacy selective laser trabeculoplasty (SLT) treatment patients with primary open-angle glaucoma (POAG) who could not obtain target intraocular pressure (IOP) through post-trabeculectomy medication. Sixteen POAG (18 eyes), IOP following medication surgery, were treated 360° SLT. IOP, anterior chamber inflammation, daytime long-term fluctuations before 2 h, 1 day, 7 days, month, 3 months, 6 months 9 after SLT documented. success...
Timolol is used topically for the treatment of glaucoma and metabolized by cytochrome P450 (CYP) 2D6 in liver. The aim this study to test hypothesis that CYP single-nucleotide polymorphism (SNP) associated with drug effects ophthalmic timolol.A total 133 primary open-angle (POAG) subjects underwent single timolol administration were observed, including lowering intraocular pressure (IOP) side (i.e., appearing bradycardia). Eight SNPs CYP2D6 investigated 73 a SNPstream genotyping system....
Abstracts Purpose: Pirfenidone is mostly used in antifibrotic and anti-inflammatory therapies. We have previously demonstrated that pirfenidone had effects on the wound healing process after glaucoma filtration surgery vitro vivo. Since reactive scarring simultaneously involves inflammation, fibrosis, angiogenesis, angiogenesis plays a more important role chronic or prolonged healing, we tried to explore antiangiogenesis effect its potential multitarget function regulating excessive...
Purpose: The aim of this study was to describe the expression and distribution 14-3-3 zeta in trabecular meshwork (TM) cells its regulatory role actomyosin system. Methods: detected using Western blot analysis, RT-PCR, immunofluorescence staining. TGF-β1 used induce cell contraction. Changes levels zeta, total RhoA, phosphorylation myosin light chain (MLC) cofilin were determined analysis. effects knockdown on actin cytoskeleton focal adhesion immunofluorescence. mRNA fibronectin collagen I...
Aims To report the baseline intraocular pressure (IOP) characteristics and its diurnal fluctuation in Laser Glaucoma Ocular Hypertension China cohort. Methods 622 primary open-angle glaucoma (POAG) patients 149 ocular hypertension (OHT) were recruited at Zhongshan Ophthalmic Center from 2015 to 2019. Standardised examinations performed including IOP measurement using Goldmann applanation tonometer. Daytime phasing was recorded 8:00, 10:00, 11:30, 14:30, 17:00 hour. Results The mean 20.2 mm...
We determined the levels of group A common and neutralizing antibodies against human rotavirus in paired serum specimens obtained from 38 infants within 12 days onset diarrhea. Thirty excreted stools, eight did not. Nine patients (30%) with diarrhea seven (88%) due to other causes had detectable (greater than or equal 1: 80) immunoglobulin (IgG) acute-phase sera. All showed at least fourfold rises titers IgG IgM both, while only two control significant either their convalescent-phase Of 19...
Abstract Primary open‐angle glaucoma (POAG) is the second leading cause of irreversible blindness worldwide. Increased endothelin‐1 (ET‐1) has been observed in aqueous humour (AH) POAG patients, resulting an increase out‐flow resistance AH. However, underlining mechanisms remain elusive. Using established vivo and vitro models, we demonstrated that water channel Aquaporin 1 (AQP1) down‐regulated trabecular meshwork (TM) cells upon ET‐1 exposure, which causes a series glaucomatous changes,...
To determine factors impacting cumulative dissipated energy (CDE) and postoperative best-corrected visual acuity (BCVA) in phacoemulsification.Review of 1102 cases at University California, San Francisco (UCSF) Zhongshan Ophthalmic Center (ZOC), China.Patients who underwent cataract surgery UCSF 03/2014-03/2019 ZOC 10/2018-05/2019.Patient demographics, medical history, routine ocular examination, surgical information, including disassembly method, complications, surgeon training level were...
Background . Retinitis pigmentosa (RP) comprises a group of inherited disorders in which patients typically lose night vision adolescence and then peripheral young adulthood before eventually losing central later life. A retrospective case-control study was performed to evaluate differences ocular biometric parameters primary angle-closure glaucoma (PACG) with without concomitant RP determine whether relationship exists between PACG RP. Methods We used ultrasound biomicroscopy (UBM) measure...
Purpose: To investigate the underlying mechanism by which pirfenidone blocks transition from G1 to S phase in primary human Tenon's fibroblasts. Methods: Primary fibroblasts were characterized immunocytofluorescence staining with vimentin, fibroblast surface protein, and cytokeratin. After treating under proliferation conditions (10% fetal bovine serum), cell was measured using a WST-1 assay. Progression through cycle analyzed flow cytometry. The expression of CDK2, CDK6, cyclinD1, cyclinD3,...
To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function sustaining delivery drug vitro vivo. Drug loading efficiency within PVA SCLs, release from SCLs vitro, effects parameters external environment on were evaluated by ultraviolet-visible spectrophotometer at 312 nm. Safety was transformed human corneal epithelial cell. vivo determined optical coherence tomography histology anterior segment rabbits. study...