A5000556383- Ocular Disorders and Treatments
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Facial Rejuvenation and Surgery Techniques
- Facial Trauma and Fracture Management
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Nasolacrimal Duct Obstruction Treatments
- Congenital Heart Disease Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- interferon and immune responses
- Ophthalmology and Visual Impairment Studies
- Immunotherapy and Immune Responses
- Dermatologic Treatments and Research
- Tracheal and airway disorders
- Complement system in diseases
- Intestinal Malrotation and Obstruction Disorders
- Retinal and Optic Conditions
- Muscle Physiology and Disorders
- Reconstructive Facial Surgery Techniques
- Nasal Surgery and Airway Studies
- Connective tissue disorders research
- Wound Healing and Treatments
Sun Yat-sen University
2015-2025
Guangzhou Medical University
2019-2024
Soochow University
2016-2023
State Key Laboratory of Ophthalmology
2022
Soochow University
2021
Zhongshan Ophthalmic Center, Sun Yat-sen University
2010-2019
Jimei University
2017
Case Western Reserve University
2006-2009
Chinese University of Hong Kong
2009
Shantou University Medical College
2009
CC chemokine ligand 2 (CCL2), a of receptor (CCR2), is essential to mount an adequate inflammatory response repair acute skeletal muscle injury. We studied the mechanisms by which CCL2 regulates inflammation and regeneration. Mobilization monocytes/macrophages (MOs/MPs) but not lymphocytes or neutrophils was impaired from bone marrow blood injured muscles in Ccl2(-/-) mice. This accompanied poor phagocytosis, reduced up-regulation insulin-like growth factor-1 (IGF-1), Bone transfer wild-type...
CC chemokine receptor 2 (CCR2) is essential to acute skeletal muscle injury repair. We studied the subpopulation of inflammatory cells recruited via CCR2 signaling and their cellular functions with respect regeneration. Mobilization monocytes/macrophages (MOs/MPs), but not lymphocytes or neutrophils, was impaired from bone marrow blood injured in Ccr2–/– mice. While Ly-6C+ Ly-6C~ subset MOs/MPs significantly reduced blood, both subsets were drastically Expression insulin-like growth...
To explore changes in lacrimal gland and tear inflammatory cytokines thyroid-associated ophthalmopathy (TAO) patients.Patients with TAO were divided into active inactive groups. These two groups the control completed Ocular Surface Disease Index (OSDI), underwent thorough ophthalmologic examinations, orbital magnetic resonance scan to measure size of gland. Basal tears, reflex tears induced by nasal stimulation serum samples, collected analyze concentrations interleukin (IL)-1β, IL-6, IL-7,...
Abstract HER2+ breast cancer (BC) is characterized by rapid growth, early recurrence, metastasis, and chemoresistance. Trastuzumab the most effective treatment for BC effectively reduces risk of recurrence death patients. Resistance to trastuzumab results in leading poor prognosis BC. In present study, we found that non-structural maintenance chromosome condensin 1 complex subunit G (NCAPG) expression was highly upregulated trastuzumab-resistant Ectopic NCAPG positively correlated with tumor...
Abstract The storage of facial images in medical records poses privacy risks due to the sensitive nature personal biometric information that can be extracted from such images. To minimize these risks, we developed a new technology, called digital mask (DM), which is based on three-dimensional reconstruction and deep-learning algorithms irreversibly erase identifiable features, while retaining disease-relevant features needed for diagnosis. In prospective clinical study evaluate technology...
Retinal ischemia-reperfusion (RIR) injury caused by high intraocular pressure (IOP) is an important risk factor contributing to retinal ganglion cell (RGC) death, eventually causing blindness. A key progressive pathological process in the development of RIR death RGCs. However, detailed mechanisms underlying RGC have not yet been clearly elucidated, and effective treatments are lacking. Ferroptosis a recently defined form programmed that closely related organ injury. Melatonin (MT) promising...
Purpose: To evaluate the expression of sry-box transcription factor 9 (SOX9) in orbital fibroblasts (OFs) thyroid eye disease (TED) and to find its potential role underlying mechanism fibrosis. Methods: OFs were cultured from connective tissues obtained patients with TED (n = 10) healthy controls 6). SOX9 was depleted by small interfering RNA or overexpressed through lentivirus transduction OFs. Fibroblast contractile activity measured collagen gel contraction assay proliferation examined...
AIM: To evaluate refraction and ocular biological characteristics in children with unilateral congenital ptosis. METHODS: In this cross-sectional study, 200 Chinese (3-15y) ptosis were evaluated. Cycloplegic measurements taken from Oct. 2020 to Aug. 2022. RESULTS: patients ptosis, the prevalence of with-the-rule astigmatism oblique was significantly high. The cornea flatter ptotic eyes [K1 (42.37±1.62 vs 42.78±1.51 D), K2 (43.8±1.86 44.2±1.64 corneal power (Km; 43.09±1.68 43.49±1.53 all...
Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays pivotal profibrotic role various inflammatory and autoimmune diseases. However, the expression pattern IL-11 patients with TAO whether mechanistically linked pathological remains unknown. In this study, we investigated levels serum orbital connective TAO, evaluated correlation these patient's clinical activity score. We also IL-11Rα...
Previous studies suggested that inflammation was involved in chronic heart failure (CHF), but their sample sizes were small.To summarise the clinical cytokine data systematically and emphasise importance of proinflammatory cytokines pathogenesis CHF, we conducted a meta-analysis relevant literatures.Articles about CHF searched Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure Wanfang Database. The pooled effects measured by weighted mean difference (MD) 95% CI,...
Abstract We previously proposed a new strategy to replace vitreous body with novel foldable capsular (FCVB). In this study, the FCVB was designed mimic natural morphology, and evaluate its physiological functions compared traditional silicone oil substitutes, in an established rabbit model of proliferative vitreoretinopathy. found that very good replacement for closely mimicking morphology restoring functions, such as support, refraction, cellular barriers, body. The study has provided us...
<b><i>Purpose:</i></b> To examine whether dry eye severity is a risk factor for pterygium activity and vascular endothelial growth (VEGF) crucial in the cross talk between eye. <b><i>Methods:</i></b> A total of 103 patients with primary (Pteg) were included study group; they divided into 2 groups according to complication (DE) (Pteg + DE group, Pteg – group). Further, 60 just (DE group) normal individuals (normal) as control groups. measured,...
Purpose: Thyroid-associated Ophthalmopathy (TAO) is one of the most common orbital immunological diseases in adults. CD4+ helper T (Th) cells play important roles pathogenesis TAO. But mechanisms regulating cell activity unclear. This study examines immunoglobulin domain and mucin 3 (TIM-3) expression type 1 (Th1), Th17, regulatory sufferers Methods: Participants were divided into groups: patients with TAO, Graves' disease but without orbitopathy (GD), healthy control (HC). Peripheral blood...
Abstract Duct-dependent congenital heart diseases (CHDs) are a serious form of CHD with low detection rate, especially in underdeveloped countries and areas. Although existing studies have developed models for fetal structure identification, there is lack comprehensive evaluation the long axis aorta. In this study, total 6698 images 48 videos collected to develop test two-stage deep transfer learning model named DDCHD-DenseNet screening critical duct-dependent CHDs. The achieves sensitivity...
Cryptophthalmos (CO, MIM: 123570) is rare congenital anomalies of eyelid formation, which can occur alone or in combination with multiple as part Fraser syndrome (FS) Manitoba Oculotrichoanal syndrome. Causal mutations have been identified for these syndromes but not the isolated cases. Here, we described two patients from unrelated Chinese families: one unilateral CO, while other CO and renal agenesis. A novel homozygous mutation (c.6499C>T: p.Arg2167Trp) compound heterozygote (c.15delG;...
To investigate whether inactive thyroid-associated ophthalmopathy (TAO) affects retinal oxygen saturation and/or vessel diameter.Via an observational case-control study, circulation was measured in patients with TAO (mild, moderate, and severe) normal subjects by oximetry. Complete ophthalmologic examination, including noncontact tonometry Hertel exophthalmometry, performed; history of smoking dysthyroid disease were recorded. Analysis variance or the Kruskal-Wallis test used to compare...