A5081228075- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Schizophrenia research and treatment
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Acupuncture Treatment Research Studies
- Corneal Surgery and Treatments
- Wastewater Treatment and Nitrogen Removal
- Traditional Chinese Medicine Studies
- Microbial Fuel Cells and Bioremediation
- Healthcare and Venom Research
- Functional Brain Connectivity Studies
- Effects and risks of endocrine disrupting chemicals
- Dermatologic Treatments and Research
- Neuroscience and Music Perception
- Microbial Community Ecology and Physiology
- Ocular Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Mental Health Research Topics
- Cerebral Venous Sinus Thrombosis
- Osteoarthritis Treatment and Mechanisms
- Vehicle emissions and performance
- Educational Technology and Pedagogy
- Bipolar Disorder and Treatment
Beijing Anding Hospital
2018-2025
Capital Medical University
2018-2025
Sun Yat-sen University
2013-2025
China University of Geosciences
2022-2025
Key Laboratory of Guangdong Province
2025
China University of Mining and Technology
2010-2024
National Clinical Research
2024
Peking University
2024
Soochow University
2024
China Electronics Technology Group Corporation
2021-2024
Purple sweet potato color (PSPC), a naturally occurring anthocyanin, has powerful antioxidant activity in vitro and vivo. This study explores whether PSPC the neuroprotective effect on aging mouse brain induced by D‐galactose (D‐gal). The mice administrated with (100 mg/kg.day, 4 weeks, from 9th week) via oral gavage showed significantly improved behavior performance open field passive avoidance test compared D‐gal‐treated (500 8 weeks). We further investigate mechanism involved effects of...
Abstract Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic transcriptional regulatory networks. Here, integrating super-enhancer chromatin accessibility landscapes, we delineate core transcription circuitries (CRCs) of limbal stem/progenitor cells (LSCs) find that RUNX1 SMAD3 required for maintenance corneal epithelial identity homeostasis. or depletion inhibits PAX6 induces LSCs to differentiate into epidermal-like cells....
Abstract The storage of facial images in medical records poses privacy risks due to the sensitive nature personal biometric information that can be extracted from such images. To minimize these risks, we developed a new technology, called digital mask (DM), which is based on three-dimensional reconstruction and deep-learning algorithms irreversibly erase identifiable features, while retaining disease-relevant features needed for diagnosis. In prospective clinical study evaluate technology...
Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production industrial and consumer surfactants. The aim present study was to evaluate effect NP on antioxidant capacity cognitive ability mice. given orally by gavages at doses 0, 50, 100, 200 mg kg(-1) d(-1) for 90 days. results showed that significantly decreased activity superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), reductase (GR) same time increased...
The objective of this study is to assess bioelectricity generation, pollutant removal (COD, ammonium, nitrate) and the bacterial communities on anodes in constructed wetlands coupled with microbial fuel cells (CW-MFCs), through feeding systems three different types synthetic wastewater (system 1: normal wastewater; system 2: ammonium-free 3: nitrate-free wastewater). Three CW-MFCs were operated concentrations hydraulic retention times (HRTs) over a long time period (6 months). results...
Purpose: To evaluate the expression of sry-box transcription factor 9 (SOX9) in orbital fibroblasts (OFs) thyroid eye disease (TED) and to find its potential role underlying mechanism fibrosis. Methods: OFs were cultured from connective tissues obtained patients with TED (n = 10) healthy controls 6). SOX9 was depleted by small interfering RNA or overexpressed through lentivirus transduction OFs. Fibroblast contractile activity measured collagen gel contraction assay proliferation examined...
Purpose: Eyelid infiltrative basal cell carcinoma (iBCC) is the most common malignant tumor affecting ocular adnexa, but studies on metabolic changes within its microenvironment and heterogeneity at invasive area are limited. This study aims to analyze differences among iBCC types using single-cell spatial metabolomics analysis examine environment area. Methods: Single-cell transcriptomic data of human (BCC) were clustered visualized Uniform Manifold Approximation Projection. Metabolic...
Abstract Background The early detection and intervention of Clinical High Risk (CHR) for psychosis, along with a clear understanding its natural course, can significantly reduce the risk minimize onset full-blown thereby improving overall prognosis (Pablo et al., 2021). Internationally, identification follow-up individuals at CHR psychosis have become increasingly sophisticated, while in China, initiation such efforts has been relatively late. Objective To determine conversion by conducting...
AIM: To evaluate refraction and ocular biological characteristics in children with unilateral congenital ptosis. METHODS: In this cross-sectional study, 200 Chinese (3-15y) ptosis were evaluated. Cycloplegic measurements taken from Oct. 2020 to Aug. 2022. RESULTS: patients ptosis, the prevalence of with-the-rule astigmatism oblique was significantly high. The cornea flatter ptotic eyes [K1 (42.37±1.62 vs 42.78±1.51 D), K2 (43.8±1.86 44.2±1.64 corneal power (Km; 43.09±1.68 43.49±1.53 all...
Abstract Forkhead box C1 (FOXC1) is required for neural crest and ocular development, mutations in FOXC1 lead to inherited Axenfeld–Rieger syndrome. Here, we find that paired 6 (PAX6) are co-expressed the human limbus central corneal epithelium. Deficiency of alternation epithelial features occur patients with ulcers. governs fate epithelium by directly binding lineage-specific open promoters or enhancers marked H3K4me2. depletion not only activates keratinization pathway reprograms cells...
With the detection of nano-plastics (NPs) in daily essentials and drinking water, potential harm NPs to human health has become focus global attention. Studies have shown that long term exposure can lead disorders glucose lipid metabolism organisms, while effects short are rarely reported. Moreover, environmental factors cause aging NPs, it is unclear whether this an effect on their toxicity. In study, we use 100 nm polystyrene (PS) ultraviolet (UV) PS (aPS) gavage mice for 7 days at dose 50...
In the present study, effects of electroacupuncture (EA) on body weight and sensitivity leptin in diet-induced obese rats were examined underlying mechanisms explored. After feeding with high-fat (HIF) diet for 12 weeks, received stimulation three times per week four weeks. The expression receptor hypothalamus was measured using immunohistochemistry. plasma detected ELISA. mRNA real-time PCR. Results showed that treatment led to a reduction weight, decrease levels, an increase hypothalamus....
Abstract The insights into how genome topology couples with epigenetic states to govern the function and identity of corneal epithelium are poorly understood. Here, we generate a high-resolution Hi-C interaction map human limbal stem/progenitor cells (LSCs) show that chromatin multi-hierarchical organisation is coupled gene expression. By integrating Hi-C, epigenome transcriptome data, characterize comprehensive 3D epigenomic landscapes LSCs. We find super-silencers mediate repression...