A5045269222- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Treatment of Major Depression
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Electroconvulsive Therapy Studies
- Mental Health and Psychiatry
- Child Abuse and Trauma
- Neurological disorders and treatments
- Diet and metabolism studies
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Treatment and Access
- Attention Deficit Hyperactivity Disorder
- Pituitary Gland Disorders and Treatments
- Personality Disorders and Psychopathology
- Hearing Loss and Rehabilitation
- Music Therapy and Health
- Family Support in Illness
- Maternal Mental Health During Pregnancy and Postpartum
Beijing Anding Hospital
2016-2025
Capital Medical University
2016-2025
National Clinical Research
2021-2024
Peking University
2024
Capital University
2024
Beijing Hospital
2021
Chinese Institute for Brain Research
2019
Beijing Chest Hospital
2018
Chinese University of Hong Kong
2010
The University of Western Australia
2010
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power data analysis approaches varied widely. The REST-meta-MDD Project resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups China established the Consortium by contributing R-fMRI from 1,300 patients with 1,128 normal controls (NCs). Data were preprocessed locally a standardized...
Abstract Background To assess the reliability and validity of Patient Health Questionnaire-9 (PHQ-9) for patients with major depressive disorder (MDD) to feasibility its use in psychiatric hospitals China. Methods One hundred nine outpatients or inpatients MDD who qualified Diagnostic Statistical Manual Mental Disorders, fourth edition (DSM-IV) criteria completed PHQ-9 Hamilton Depression Scale (HAMD-17). Two weeks after initial evaluation, 54 randomly selected underwent repeat assessment...
Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed characterize using a large multi-site sample novel network-based approach. Resting-state magnetic resonance imaging (fMRI) data were acquired from total 460 473 healthy controls, as part REST-meta-MDD consortium. networks constructed for each subject...
Major depressive disorder (MDD) is heterogeneous associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity disorder. The sample comprised 1397 participants including 690 patients 707 healthy controls (HC) registered from multiple sites based REST-meta-MDD Project in China. Baseline resting-state magnetic resonance imaging (rs-fMRI)...
Abstract Working memory deficits are linked to irregularities in the dorsolateral prefrontal cortex (DLPFC) and posterior parietal (PPC) schizophrenia, effective intervention strategies lacking. We evaluated differential efficacy underlying neuromechanisms of targeting transcranial direct current stimulation (tDCS) at DLPFC PPC with concurrent cognitive performance for working schizophrenia. In a randomized double-blind clinical trial, sixty clinically stable schizophrenic patients...
Theoretical and empirical evidence indicates the critical role of default mode network (DMN) in pathophysiology bipolar disorder (BD). This study aims to identify specific brain regions DMN that is impaired patients with BD.
Mismatch negativity (MMN) has been consistently found deficit in schizophrenia, which was considered as a promising biomarker for assessing the impairments pre-attentive auditory processing. However, functional connectivity between brain regions based on MMN is not clear. This study provides an in-depth investigation during process among patients with first-episode schizophrenia (FESZ), chronic (CSZ) and healthy control (HC). Electroencephalography (EEG) data of 128 channels recorded...
Prevention of relapse is the crucial task in maintenance treatment schizophrenia. The investigators this study sought to determine duration needed with initial therapeutic dose, contrast a reduced dose.In multicenter open-label, randomized, controlled study, patients schizophrenia who were clinically stabilized following an acute episode randomly assigned no-dose-reduction group (initial optimal dose continued throughout study), 4-week for 4 weeks, followed by 50% reduction that was...
Background Hyperprolactinemia is a common antipsychotic-induced adverse event in psychiatric patients, and the quality of clinical studies investigating best treatments has varied. Thus, to better summarize evidence, we performed an umbrella review overlapping systematic reviews meta-analyses for treatment hyperprolactinemia. Methods The PubMed, Cochrane Library, PsycINFO, Scopus EMBASE were searched, meeting our inclusion criteria selected. Relevant data extracted, was conducted all...
Background Patients with bipolar disorder (BD) frequently exhibit cognitive impairments. However, the association between childhood trauma as a risk factor for BD and deficits remains ambiguous. Objective To investigate relationship function among patients BD. Methods The study included 90 94 healthy controls (HC). Childhood was assessed using Trauma Questionnaire (CTQ), evaluated Repeatable Battery Assessment of Neuropsychological Status (RBANS). relationships function. Results In group,...
Abstract Background Attenuated positive symptoms syndrome (APSS) is a risk state preceding psychosis. Disturbances in the frontal-striatal-thalamic circuit have been implicated neuropathology of APSS. This study aimed to systematically investigate white matter (WM) alterations frontal -striatal- thalamic Methods Diffusion magnetic resonance imaging (dMRI) and T1-weighted images were acquired from 43 individuals with APSS 50 healthy controls (HCs). The dMRI data preprocessed using FSL...
Abstract Background Suicide is the primary cause of death in patients with major depressive disorder (MDD) or bipolar (BD). However, effects personality traits on suicide risk MDD BD have not been examined sufficiently. This study characterized BD, and analyzed association between these patients. Methods The population comprised 88 90 We assessed lifetime by using SCID-I/P. Additionally, current was judged based third item (suicide) 17-item Hamilton Depression Rating Scale. Personality were...
Abstract Background The early detection and intervention of Clinical High Risk (CHR) for psychosis, along with a clear understanding its natural course, can significantly reduce the risk minimize onset full-blown thereby improving overall prognosis (Pablo et al., 2021). Internationally, identification follow-up individuals at CHR psychosis have become increasingly sophisticated, while in China, initiation such efforts has been relatively late. Objective To determine conversion by conducting...
Abstract Background Currently, there is increasing attention paid to early psychiatric populations such as first episode of schizophrenia (FES) and clinical high risk for (CHR). Research based on static functional connectivity (FC) has unanimously recognized abnormalities in the salience network (SN) schizophrenia, but still controversy over whether these will fully extend stages mental illness. Aims The aim this study evaluate interaction characteristics networks level assessment. Methods...