Glaucoma is a leading cause of irreversible blindness. Injury retinal ganglion cells (RGCs) accounts for visual impairment glaucoma. Here, we report rapamycin protects RGCs from death in experimental glaucoma model and the underlying mechanisms. Our results showed that treatment with dramatically promote survival rat chronic ocular hypertension model. This protective action appears to be attributable inhibition neurotoxic mediators release and/or direct suppression RGC apoptosis. In support...

Objective: The aim of our study was to investigate the relationship among age, sex, body mass index (BMI), serum lipid profiles, blood glucose (BG), and bone mineral density (BMD), making an assessment risk osteoporosis. Materials methods: A total 1,035 male 3,953 female healthy volunteers (aged 41–95 years) were recruited by open invitation. basic information, including height, weight, waistline, hipline, menstrual cycle, medical history, collected a questionnaire survey physical...

Traumatic dacryocystitis is a rare complication of nasolacrimal duct obstruction (NLDO) resulting from naso-orbito-ethmoid (NOE) fractures. NLDO following orbital fracture reconstruction using an implant even less prevalent. Few cases have reported the best treatment strategy for traumatic caused by due to compression displaced bony fragments in patients who undergone with implant. This study presents case recurring lacrimal sac abscess post-traumatic patient had previously The no evidence...

Lacrimal irrigation is a fundamental skill for diagnosing and managing lacrimal diseases. This study evaluates two techniques introduces haptic-visual integrated self-serve training model to enhance acquisition among novice ophthalmology residents. Ninety-two residents were randomized into Group A (n = 47) B 45). Both groups completed an 8-hour program comprising theoretical instruction, demonstrations, hands-on practice. provided feedback refine the model, which was subsequently implemented...

AIM: To evaluate refraction and ocular biological characteristics in children with unilateral congenital ptosis. METHODS: In this cross-sectional study, 200 Chinese (3-15y) ptosis were evaluated. Cycloplegic measurements taken from Oct. 2020 to Aug. 2022. RESULTS: patients ptosis, the prevalence of with-the-rule astigmatism oblique was significantly high. The cornea flatter ptotic eyes [K1 (42.37±1.62 vs 42.78±1.51 D), K2 (43.8±1.86 44.2±1.64 corneal power (Km; 43.09±1.68 43.49±1.53 all...

Mesenchymal stem cells (MSCs) have been demonstrated to promising therapeutic benefits for a variety of neurological diseases; however, the underlying mechanisms are poorly understood. Here, we showed that intravitreal infusion MSCs promoted retinal ganglion cell (RGC) survival in mouse model acute glaucoma, with significant inhibition microglial activation, production TNF-α, IL-1β, and reactive oxygen species, as well caspase-8 caspase-3 activation. In vitro, inhibited both...

Cash holdings are an essential element of corporate decision-making. Culture, such as the unique Chinese red culture created by Communist Party China during Revolutionary War, affected economic decisions. This study systematically evaluated impact on cash holdings. Based a theoretical analysis, this conducts empirical analysis using data Chinese-listed companies from 2008 to 2021. The results show that: (1) reduces For each unit cultural influence, decreased 1.5979% points. (2) role in...

This study aimed to elucidate the impact of upadacitinib, a Janus kinase 1 (JAK1)-specific inhibitor, on experimental autoimmune uveitis (EAU) and explore its underlying mechanisms.We utilized single-cell RNA sequencing (scRNA-seq) assay for transposase-accessible chromatin (scATAC-seq) investigate JAK/signal transducer activator transcription (STAT) pathway in peripheral blood mononuclear cells (PBMCs) 12 patients with Vogt-Koyanagi-Harada (VKH) disease cervical draining lymph node (CDLN)...

A systematic analysis shows that the main uncertainties in form factors are due to twist-3 wave functions of light mesons light-cone QCD sum rules. We propose an improved approach, which doesn't make any contribution and therefore possible pollution by them can be avoided, re-examine $B \to π$ semileptonic factors. Also, a comparison between previous our results from rules is made. Our method will beneficial precise extracting $\mid{V_{ub}}\mid$ experimental data on processes π\ell...

We make a QCD light-cone sum rule assessment of ${B}_{(s)}$ semileptonic decays to light scalar meson, ${B}_{(s)}\ensuremath{\rightarrow}Sl{\overline{\ensuremath{\nu}}}_{l}$, $Sl\overline{l}(l=e,\ensuremath{\mu},\ensuremath{\tau})$. Chiral current correlators are used and calculations performed at leading order in ${\ensuremath{\alpha}}_{s}$. Having little knowledge the ingredients mesons, we confine ourself two-quark picture for them work with two possible scenarios. The resulting rules...

B meson semi-leptonic rare decays are sensitive to new physics beyond standard model. We study the $B^{-}\to \pi^{-}\mu^{+}\mu^{-}$ process and investigate Majorana neutrino contribution its decay width. The constraints on mass mixing parameter obtained from this channel with latest LHCb data. Utilizing best fit for parameters, we lepton number violating \pi^{+}\mu^{-}\mu^{-}$, find branching ratio is about $6.4\times10^{-10}$, which consistent data reported recently.

Objective: People with type 2 diabetes are at an increased risk of hypertension, arteriosclerosis, heart disease, and stroke. Glucose intolerance (insulin resistance) is the main feature diabetes. Obesity leads to insulin resistance, dyslipidemia, etc. The aim this study was assess biochemical parameters measures obesity in mellitus (T2DM). Methods: A total 2,273 males 6,547 females previously healthy volunteers (aged 41–95 years old) were recruited by open invitation. basic information,...

Purpose: To compare the eye with chronic primary angle-closure glaucoma (CPACG) its fellow without damage and to determine biometric differences that may predispose development of CPACG. Methods: Consecutive patients diagnosed CPACG in 1 (PAC)/primary suspected (PACS) were recruited. The parameters both eyes measured by A-scan ultrasonic biometry ultrasound biomicroscopy. Comparisons visual function, baseline intraocular pressure (IOP), measurements made. Results: Forty-one Eyes had worse...

Purpose The aim of this study was to analyze dry eye disease (DED) in patients with functioning filtering blebs and explore the relationship between morphology ocular surface instability. Methods This a cross-sectional, case-comparison study. Seventy glaucomatous (70 eyes) who had undergone trabeculectomy more than 6 months prior (study group) 35 control subjects (35 (control were included. All completed an symptom questionnaire that referred Shihpai Eye Study. Evaluation meibomian gland...

Abstract Background Dimethyl fumarate (DMF) is a fumaric acid ester that exhibits immunoregulatory and anti-inflammatory properties. However, the function of DMF in autoimmune uveitis (AU) incompletely understood, studies comprehensively exploring impact on immune cells are still lacking. Methods To explore its underlying mechanisms, we conducted single-cell RNA sequencing (scRNA-seq) cervical draining lymph node (CDLN) normal, experimental (EAU), DMF-treated EAU mice. Additionally,...

Metformin (Met) is a therapeutic agent for the treatment of type 2 diabetes mellitus. There evidence that Met may reduce risk cancer in patients with mellitus by inhibiting tumor cell growth, prolonging overall survival time various types malignancy. However, function and mechanism have not been fully elucidated osteosarcoma (OS). The present study evaluated anti-proliferative effect on MG63 U2OS OS cells, identifying it acted dose- time-dependent manner. also inhibited migration invasion,...

Semileptonic B(B s , B c ) decays are investigated systematically in the light-cone QCD sum rules. Special emphasis is put on LCSR calculation weak form factors with an adequate chiral current correlator, which turns out to be particularly effective control pollution by higher twist components of spectator mesons. The result for each channel depends distribution amplitude producing meson. leading amplitudes related heavy mesons and charmonium worked a model approach reasonable way. A...

A new estimate of the electromagnetic penguin operator contribution to $\stackrel{\ensuremath{\rightarrow}}{B}{K}^{*}\ensuremath{\gamma}$ is proposed by using light-cone QCD sum rule. We improve previous investigation Ali, Braun and Simma proper choices current operators in correlator. The reasonable estimates $b$-quark pole mass ${m}_{b}$ decay constant ${f}_{B}$ are also given. Numerically, we find that form factor...

We study the $$B_s \rightarrow \pi ^+ ^-$$ and $$B_d K^+ K^-$$ decays in standard model family-non-universal $$Z^\prime $$ model. Since none of quarks final states is same as initial quark, these decay modes can occur only via power-suppressed annihilation diagrams. Despite consistency prediction with available data, room remains for a light boson. Taking into account contribution, we find that theoretical results branching fractions better accommodate data. With relevant also derive...

Within the framework of QCD light-cone sum rules (LCSR), we calculate form factor for $B{\to}D l\tildeν$ transitions with chiral current correlator. The resulting depends on distribution amplitude(DA) $D$-meson. We try to use three kinds DA models In velocity transfer region $1.14 < y 1.59$, which renders Operator Product Expansion (OPE) near $x^2=0$ go effectively, yielding behavior is in agreement that extracted from data $ B\to D l\tildeν$, within error. larger recoil $1.35 results are...

We make an evaluation of the lepton flavor violating (LFV) decays $τ\to \ell (V^0, P^0)$, where $\ell=e$ or $μ$ and $V^0(P^0)$ is a neutral vector (pseudo-scalar) meson, in context unparticle physics. The constraints are investigated systematically on related coupling parameters from all available experimental data, parameter values specified appropriately. results show that whereas over whole space allowed by experiments P^0$ modes have branching ratio too small to be measurable...